Call Sequence Prediction through Probabilistic Calling Automata

Predicting a sequence of upcoming function calls is important for optimizing programs written in modern managed languages (e.g., Java, Javascript, C#.) Existing function call predictions are mainly built on statistical patterns, suitable for predicting a single call but not a sequence of calls. This paper presents a new way to enable call sequence prediction, which exploits program structures through Probabilistic Calling Automata (PCA), a new program representation that captures both the inherent ensuing relations among function calls, and the probabilistic nature of execution paths. It shows that PCA-based prediction outperforms existing predictions, yielding substantial speedup when being applied to guide Just-In-Time compilation. By enabling accurate, efficient call sequence prediction for the first time, PCA-based predictors open up many new opportunities for dynamic program optimizations

Mapping the Galactic disk with the LAMOST and Gaia Red clump sample: VIII: Mapping the kinematics of the Galactic disk using mono-age and mono-abundance stellar populations

We present a comprehensive study of the kinematic properties of the different Galactic disk populations, as defined by the chemical abundance ratios and stellar ages, across a large disk volume (4.5 $\leq$ R $\leq$ 15.0 kpc and $|Z|$ $\leq$ 3.0 kpc), by using the LAMOST-Gaia red clump sample stars. We determine the median velocities for various spatial and population bins, finding large-scale bulk motions, such as the wave-like behavior in radial velocity, the north-south discrepancy in azimuthal velocity and the warp signal in vertical velocity, and the amplitudes and spatial-dependences of those bulk motions show significant variations for different mono-age and mono-abundance populations. The global spatial behaviors of the velocity dispersions clearly show a signal of spiral arms and, a signal of the disk perturbation event within 4 Gyr, as well as the disk flaring in the outer region (i.e., $R \ge 12$ kpc) mostly for young or alpha-poor stellar populations. Our detailed measurements of age/[$\alpha$/Fe]-velocity dispersion relations for different disk volumes indicate that young/$\alpha$-poor populations are likely originated from dynamically heated by both giant molecular clouds and spiral arms, while old/$\alpha$-enhanced populations require an obvious contribution from other heating mechanisms such as merger and accretion, or born in the chaotic mergers of gas-rich systems and/or turbulent interstellar medium.Comment: 35 pages, 31 figures, 3 tables, accepted for publication in Ap

Weak feedback assisted random fiber laser from 45°-tilted fiber Bragg grating

We have demonstrated the realization of a high-polarization random fiber laser (RFL) output based on the hybrid Raman and Erbium gain with the tailored effect provided by a 45°-tilted fiber Bragg grating (45°-TFBG), revealing an improvement in the polarization extinction ratio (PER) and achieving a PER of ~15.3 dB. The hybrid RFL system incorporating the 45°-TFBG has been systematically characterized. The random lasing wavelength can be fixed under the extremely weak feedback effect of the 45°-TFBG with reflectivity of 0.09%. In addition, numerical simulation has verified that the weak feedback can boost the random lasing emission with fixed wavelength using a power balance model, which is in good accordance with the experiment results

Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese

Background and purpose Previous studies, mostly focusing on the European population, have reported polygenic risk scores (PRSs) might achieve risk stratification of stroke. We aimed to examine the association strengths of PRSs with risks of stroke and its subtypes in the Chinese population. Methods Participants with genome-wide genotypic data in China Kadoorie Biobank were split into a potential training set (n=22 191) and a population-based testing set (n=72 150). Four previously developed PRSs were included, and new PRSs for stroke and its subtypes were developed. The PRSs showing the strongest association with risks of stroke or its subtypes in the training set were further evaluated in the testing set. Cox proportional hazards regression models were used to estimate the association strengths of different PRSs with risks of stroke and its subtypes (ischaemic stroke (IS), intracerebral haemorrhage (ICH) and subarachnoid haemorrhage (SAH)). Results In the testing set, during 872 919 person-years of follow-up, 8514 incident stroke events were documented. The PRSs of any stroke (AS) and IS were both positively associated with risks of AS, IS and ICH (p<0.05). The HR for per SD increment (HRSD) of PRSAS was 1.10 (95% CI 1.07 to 1.12), 1.10 (95% CI 1.07 to 1.12) and 1.13 (95% CI 1.07 to 1.20) for AS, IS and ICH, respectively. The corresponding HRSD of PRSIS was 1.08 (95% CI 1.06 to 1.11), 1.08 (95% CI 1.06 to 1.11) and 1.09 (95% CI 1.03 to 1.15). PRSICH was positively associated with the risk of ICH (HRSD=1.07, 95% CI 1.01 to 1.14). PRSSAH was not associated with risks of stroke and its subtypes. The addition of current PRSs offered little to no improvement in stroke risk prediction and risk stratification. Conclusions In this Chinese population, the association strengths of current PRSs with risks of stroke and its subtypes were moderate, suggesting a limited value for improving risk prediction over traditional risk factors in the context of current genome-wide association study under-representing the East Asian population

Minimal improvement in coronary artery disease risk prediction in Chinese population using polygenic risk scores: evidence from the China Kadoorie Biobank

Background: Several studies have reported that polygenic risk scores (PRSs) can enhance risk prediction of coronary artery disease (CAD) in European populations. However, research on this topic is far from sufficient in non-European countries, including China. We aimed to evaluate the potential of PRS for predicting CAD for primary prevention in the Chinese population. Methods: Participants with genome-wide genotypic data from the China Kadoorie Biobank were divided into training (n = 28,490) and testing sets (n = 72,150). Ten previously developed PRSs were evaluated, and new ones were developed using clumping and thresholding or LDpred method. The PRS showing the strongest association with CAD in the training set was selected to further evaluate its effects on improving the traditional CAD risk-prediction model in the testing set. Genetic risk was computed by summing the product of the weights and allele dosages across genome-wide single-nucleotide polymorphisms. Prediction of the 10-year first CAD events was assessed using hazard ratios (HRs) and measures of model discrimination, calibration, and net reclassification improvement (NRI). Hard CAD (nonfatal I21–I23 and fatal I20–I25) and soft CAD (all fatal or nonfatal I20–I25) were analyzed separately. Results: In the testing set, 1214 hard and 7201 soft CAD cases were documented during a mean follow-up of 11.2 years. The HR per standard deviation of the optimal PRS was 1.26 (95% CI:1.19–1.33) for hard CAD. Based on a traditional CAD risk prediction model containing only non-laboratory-based information, the addition of PRS for hard CAD increased Harrell's C index by 0.001 (–0.001 to 0.003) in women and 0.003 (0.001 to 0.005) in men. Among the different high-risk thresholds ranging from 1% to 10%, the highest categorical NRI was 3.2% (95% CI: 0.4–6.0%) at a high-risk threshold of 10.0% in women. The association of the PRS with soft CAD was much weaker than with hard CAD, leading to minimal or no improvement in the soft CAD model. Conclusions: In this Chinese population sample, the current PRSs minimally changed risk discrimination and offered little to no improvement in risk stratification for soft CAD. Therefore, this may not be suitable for promoting genetic screening in the general Chinese population to improve CAD risk prediction