CSU 4th Annual Regional Chemistry Symposium: March 12 & 13, 2015

CSU 4th Annual Regional Chemistry Symposium: March 12 & 13, 2015 Register here for the 4th Annual Regional Chemistry Symposium March 12 & 13, 2015 Fee: $100 for two days$50 for one day Limited Time special registration fee! The registration fee for the two-day symposium is $100 and includes breakfast, lunch, an outstanding wine and cheese social hour, and discount rates on lodging. A schedule of events will also include a list of Cleveland\u27s best sights, sounds and tastes. To pay with credit card, visit CSU\u27s ShopNet page at https://campusnet.csuohio.edu/ShopNet/index.jsp You may also pay the fee in person on the day of the symposium at the registration table or mail in your check or money order, payable to Cleveland State University, to: Chemistry Teaching Symposium Attn: Dr. Jerry Mundell SI 332 Department of Chemistry c/o Cleveland State University 2121 Euclid Ave Cleveland, Ohio 44115-221

CSU 4th Annual Regional Chemistry Symposium: March 12 & 13, 2015

CSU 4th Annual Regional Chemistry Symposium: March 12 & 13, 2015 Register here for the 4th Annual Regional Chemistry Symposium March 12 & 13, 2015 Fee: $100 for two days$50 for one day Limited Time special registration fee! The registration fee for the two-day symposium is $100 and includes breakfast, lunch, an outstanding wine and cheese social hour, and discount rates on lodging. A schedule of events will also include a list of Cleveland\u27s best sights, sounds and tastes. To pay with credit card, visit CSU\u27s ShopNet page at https://campusnet.csuohio.edu/ShopNet/index.jsp You may also pay the fee in person on the day of the symposium at the registration table or mail in your check or money order, payable to Cleveland State University, to: Chemistry Teaching Symposium Attn: Dr. Jerry Mundell SI 332 Department of Chemistry c/o Cleveland State University 2121 Euclid Ave Cleveland, Ohio 44115-221

Effects of different immunosuppressive drugs on the periodontal status and changes in periodontal pathogenic bacterial flora in rheumatoid arthritis patients

Purpose: To investigate the prevalence of periodontal disease(s) and the associated bacteria among rheumatoid arthritis (RA) patients treated with different immunosuppressive drugs.Methods: Patients aged 18 – 65 years who had a 6-month history of RA, and were diagnosed as per the American College of Rheumatology and European League against Rheumatism, were included in the study. Supragingival plaque was removed by dentists. Using sterile paper strips, sub-gingival biofilm samples were collected from 5 of the deepest periodontal pockets. The samples were sent to pathologists for assessment. Polymerase chain reaction was carried out on them. Detection thresholds were >102 for Aggregatibacter actinomycetemcomitans, while the detection threshold for Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia,  Fusobacterium nucleatum, Campylobacter rectus, Eubacterium nodatum, Eikenellacorrodens, and Capnocytophaga species was 103.Results: There was a higher number of patients with bleeding-on-probing amongst cohorts who received a combination of methotrexate and tumor necrosis factor-α antagonist than in those given leflunomide only (52 vs. 29, p = 0.041, q = 3.064), or methotrexate + rituximab (52 vs. 30, p = 0.041, q = 3.131, Fig. 1). Papilla bleeding index was lowest in patients who were treated with leflunomide. Almost all patients had dental infection with Fusobacterium nucleatum.Conclusion: These results indicate that treatment of RA with methotrexate results in periodontal inflammation

Controlling photons by phonons via giant atom in a waveguide QED setup

We investigate the single photon scattering in a phonon-photon hybrid system in the waveguide QED scheme. In our consideration, an artificial giant atom, which is dressed by the phonons in a surface acoustic wave resonator, interacts with a coupled resonator waveguide (CRW) nonlocally via two connecting sites. Together with the interference effect by the nonlocal coupling, the phonon serves as a controller to the transport of the photon in the waveguide. On the one hand, the coupling strength between the giant atom and the surface acoustic wave resonator modulates the width of the transmission valley or window in the near resonant regime. On the other hand, the two reflective peaks induced by the Rabi splitting degrade into a single one when the giant atom is large detuned from the surface acoustic resonator, which implies an effective dispersive coupling. Our study paves the way for the potential application of giant atoms in the hybrid system.Comment: 4 Pages, 4 Figures, Published on Optics Letter

In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus.

Packaging of the genome into a protein capsid and its subsequent delivery into a host cell are two fundamental processes in the life cycle of a virus. Unlike double-stranded DNA viruses, which pump their genome into a preformed capsid, single-stranded RNA (ssRNA) viruses, such as bacteriophage MS2, co-assemble their capsid with the genome; however, the structural basis of this co-assembly is poorly understood. MS2 infects Escherichia coli via the host 'sex pilus' (F-pilus); it was the first fully sequenced organism and is a model system for studies of translational gene regulation, RNA-protein interactions, and RNA virus assembly. Its positive-sense ssRNA genome of 3,569 bases is enclosed in a capsid with one maturation protein monomer and 89 coat protein dimers arranged in a T = 3 icosahedral lattice. The maturation protein is responsible for attaching the virus to an F-pilus and delivering the viral genome into the host during infection, but how the genome is organized and delivered is not known. Here we describe the MS2 structure at 3.6 Å resolution, determined by electron-counting cryo-electron microscopy (cryoEM) and asymmetric reconstruction. We traced approximately 80% of the backbone of the viral genome, built atomic models for 16 RNA stem-loops, and identified three conserved motifs of RNA-coat protein interactions among 15 of these stem-loops with diverse sequences. The stem-loop at the 3' end of the genome interacts extensively with the maturation protein, which, with just a six-helix bundle and a six-stranded β-sheet, forms a genome-delivery apparatus and joins 89 coat protein dimers to form a capsid. This atomic description of genome-capsid interactions in a spherical ssRNA virus provides insight into genome delivery via the host sex pilus and mechanisms underlying ssRNA-capsid co-assembly, and inspires speculation about the links between nucleoprotein complexes and the origins of viruses