Research on Risk Assessment Technology of the Major Hazard in Harbor Engineering

AbstractThe increased construction of harbor infrastructure has led to distinct safety problems recently. A lack of an efficient risk assessment method to evaluate the major hazard (procedure) in harbor engineering has become a vital reason for frequent grave accidents in harbor engineering area. This work, taking the features of harbor engineering into account and starting from the basic concept of “risk”, sets a risk level evaluation standard for both accident consequence measure index and accident possibility measure index based on the survey of current situation of construction enterprises, thus realizing the quantitative assessment and classification towards major hazard and providing rules for major hazard risk assessment on harbor engineering project in the future

Quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes.

BackgroundDiabetes mellitus (DM) is considered a cardiovascular risk factor. The aim of this study was to analyze the prevalence and volume of coronary artery plaque in patients with diabetes mellitus (DM) vs. those without DM.MethodsThis study recruited consecutive patients who underwent coronary computed tomography (CT) angiography (CCTA) between October 2016 and November 2017. Personal information including conventional cardiovascular risk factors was collected. Plaque phenotypes were automatically calculated for volume of different component. The volume of different plaque was compared between DM patients and those without DM.ResultsAmong 6381 patients, 931 (14.59%) were diagnosed with DM. The prevalence of plaque in DM subjects was higher compared with nondiabetic group significantly (48.34% vs. 33.01%, χ = 81.84, P < 0.001). DM was a significant risk factor for the prevalence of plaque in a multivariate model (odds ratio [OR] = 1.465, 95% CI: 1.258-1.706, P < 0.001). The volume of total plaque and any plaque subtypes in the DM subjects was greater than those in nondiabetic patients significantly (P < 0.001).ConclusionThe coronary artery atherosclerotic plaques were significantly higher in diabetic patients than those in non-diabetic patients

Significance of ocular surface interferometer in the diagnosis of Meibomian gland dysfunction

AIM: To investigate the significance of ocular surface interferometer in the diagnosis of Meibomian gland dysfunction(MGD).METHODS: Prospective case-control studies. Totally 62 patients with MGD and 38 healthy volunteers were selected in Peking University Third Hospital from October to November in 2017. All subjects of both groups were examined respectively for Ocular Surface Disease Index Questionnaire(OSDI), slit-lamp anterior segment check, the eye surface interferometer inspection, and break up time. Independent sample t-test and chi-square test were used for comparison between the two groups. Spearman correlation analysis was used in the group of patients with MGD. RESULTS: In both groups, there were changes on the morphology of the eyelid, and the lesions were different. The score of OSDI, the discharge ability and the loss score of the MGD group were significantly higher than those in the control group(P). However, the lipid layer thickness(LLT)was significantly lower than that in the control group(P). There was no significant difference in BUT, the proportion of incomplete blink time, the score of Meibomian gland orifice and the quality score of the Meibomian gland discharge ability between the two groups(P>0.05). The Spearman correlation analysis indicated that the negative correlation between LLT and the OSDI questionnaire score(rs=-0.730, Prs=-0.639, Prs=-4.15, P=0.001); however, the positive correlation was shown between the loss of Meibomian gland and the OSDI questionnaire score(rs=0.790, PCONCLUSION: Meibomian gland dysfunction symptoms and signs significantly correlates with LLT, loss of Meibomian gland detected by ocular surface interferometer, so ocular surface interferometer can be used for rapid, noninvasive and objective diagnosis of Meibomian gland dysfunction and assess the stage of disease progression

No relationship between the distribution of mast cells and the survival of stage IIIB colon cancer patients

<p>Abstract</p> <p>Background</p> <p>Mast cells promote the progression of experimental tumors and might be a valuable therapeutic target. However, the relevant clinical evidence is still controversial. This study analyzed the relationship between the distribution of mast cells and the survival of patients with colon cancer to study whether mast cells contribute to tumor progression.</p> <p>Materials and methods</p> <p>Ninety-three cases of pathologically confirmed primary cancer tissues matched with adjacent normal mucosa, metastases of regional-draining lymph nodes and regional-draining lymph nodes without metastases were collected from stage IIIB colon carcinoma patients between January 1997 and July 2004 at the Cancer Center of Sun Yat-Sen University. Tryptase-positive mast cells were counted. The relationships of the distribution of mast cells with clinicopathologic parameters and 5-year survival were analyzed.</p> <p>Results</p> <p>Although the mast cell count in the mucosa adjacent to the primary colon cancer was significantly higher than that in the stroma of the primary colon cancer, no difference in mast cell counts was observed between the stroma in lymph node metastasis and the lymph tissue adjacent to the metastasis. Additionally, the mast cell count in the regional-draining lymph node without the invasion of cancer cells was significantly higher than that in the stroma of lymph node metastasis and adjacent lymph tissue. However, none of those mast cell counts was related to 5-year survival.</p> <p>Conclusion</p> <p>Although mast cell count varied with location, none of the mast cell counts was related to 5-year survival, suggesting that mast cells do not contribute to the progression of stage IIIB colon cancer.</p

Longitudinal optical conductivities in tilted Dirac bands

We report a unified theory based on linear response, for analyzing the longitudinal optical conductivity (LOC) of materials with tilted Dirac cones. Depending on the tilt parameter $t$, the Dirac electrons have four phases, untilted, type-I, type-II, and type-III; the Dirac dispersion can be isotropic or anisotropic; the spatial dimension of the material can be one-, two-, or three-dimensions. The interband LOCs and intraband LOCs in $d$ dimension (with $d\ge2$) are found to scale as to $\sigma_{0}\omega^{d-2}$ and $\sigma_{0}|\mu|^{d-1}\delta(\omega)$, respectively, where $\omega$ is the frequency and $\mu$ the chemical potential. The interband LOCs always vanish in one dimension due to lacking of extra spatial dimension. The angular dependence of LOCs is found to characterize the band tilting, and the constant asymptotic background values of LOC reflect features of the Dirac bands. The LOCs in the anisotropic tilted Dirac cone can be connected to its isotropic counterpart by a ratio that consists of Fermi velocities. The findings are valid for a great many Dirac materials in the spatial dimensions of physical interests.Comment: 11 pages, 3 figure

Adiponectin alleviate blood hypercoagulability via inhibiting endothelial cell apoptosis induced by oxidative stress in septic rats

Objective(s): The purpose of this study was to detect the protective effects of adiponectin on coagulation dysfunction and its mechanism in sepsis of rats.Materials and Methods: The experimental samples were composed of sham group,   model group that was underwent cecal ligation and puncture (CLP) and three adiponectin treatment groups that treated by adiponectin with different dose (72 μg/kg, 96 μg/kg and 120 μg/kg) after CLP. The prothrombin time (PT), activated partial thromboplastin time (APTT) was measured, respectively, the level of malondialdehyde (MDA), tissue factor (TF), activated coagulation factor VIIa and Xa, p-selectin were detected, the histology structure of vascular was observed, the expressions of Caspase 9, Caspase 3, Bax, Bcl-2 and vWF in vascular were measured.Results: The results demonstrated that adiponectin treatment lengthened PT and APTT, reduced the expression of MDA, TF, activated coagulation factor VIIa, Xa and p-selectin in plasma of septic rats. Additionally, adiponectin treatment alleviated endothelial cell apoptosis and oxidative stress, down-regulated the levels of Caspase 3, Caspase 9, Bax, Bcl-2 and vWF in vascular.Conclusion: These findings suggest that adiponectin treatment might be a promising therapeutic strategy for relieving septic endothelial cell injury and coagulation dysfunction via inhibiting endothelial cell apoptosis in septic rats

Inverse Kinematics Obstacle Avoidance Solution for Industrial Robot Based on Quaternion - 基于四元数的工业机器人逆运动学避障求解

With the development of artificial intelligence technology, industrial robots are widely used in work scenarios such as gripping and handling. However, due to the complex inverse kinematics solution and the existence of multiple solutions for poses, the robot has poor robustness and its industrial application range is limited. To simplify the solving process of inverse kinematics of industrial robot and realize the accurate control of robot pose in complex obstacle scene, quaternion was used to solve the robot pose, and an improved particle swarm optimization algorithm (F-PSO) was proposed combined with obstacle avoidance module in this paper. Through the comparative experimental analysis with the simulated annealing algorithm (SA) and the genetic algorithm (GA) under different target poses, it was proved that the F-PSO algorithm performed better, and the convergence accuracy was more than 36.41% higher than that of the traditional algorithm. The F-PSO algorithm was more than 83.82% faster than the traditional algorithm. The experimental results showed that the F-PSO algorithm proposed in this paper can not only precisely control the pose of the robot, but also effectively improve the work efficiency and realize the optimization of the robot gripping process in the complex obstacle scene

The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer

<p>Abstract</p> <p>Background</p> <p>Although an abundance of evidence has indicated that tumor-associated macrophages (TAMs) are associated with a favorable prognosis in patients with colon cancer, it is still unknown how TAMs exert a protective effect. This study examined whether TAMs are involved in hepatic metastasis of colon cancer.</p> <p>Materials and methods</p> <p>One hundred and sixty cases of pathologically-confirmed specimens were obtained from colon carcinoma patients with TNM stage IIIB and IV between January 1997 and July 2004 at the Cancer Center of Sun Yat-Sen University. The density of macrophages in the invasive front (CD68TF_Hotspot) was scored with an immunohistochemical assay. The relationship between the CD68TF_Hotspotand the clinicopathologic parameters, the potential of hepatic metastasis, and the 5-year survival rate were analyzed.</p> <p>Results</p> <p>TAMs were associated with the incidence of hepatic metastasis and the 5-year survival rate in patients with colon cancers. Both univariate and multivariate analyses revealed that the CD68TF_Hotspotwas independently prognostic of survival. A higher 5-year survival rate among patients with stage IIIB after radical resection occurred in patients with a higher macrophage infiltration in the invasive front (81.0%) than in those with a lower macrophage infiltration (48.6%). Most importantly, the CD68TF_Hotspotwas associated with both the potential of hepatic metastasis and the interval between colon resection and the occurrence of hepatic metastasis.</p> <p>Conclusion</p> <p>This study showed evidence that TAMs infiltrated in the invasive front are associated with improvement in both hepatic metastasis and overall survival in colon cancer, implying that TAMs have protective potential in colon cancers and might serve as a novel therapeutic target.</p