50 research outputs found
Research on rational layout of strut arms of tainter gate in vertical frame
The overall stability of hydraulic tainter steel gate decrease seriously, and they are caused by improper structure layout of the two-way eccentric compression of struts. Chinese and American specification method, structural mechanics method and finite element method are respectively used to study rational structural layout of strut arms in vertical frame. First of all, a unified method for rational layout of struts of tainter gate in vertical frame is deduced by using structural mechanics method that simplifies curve girder as straight girder on the basis of zero rotation in vertical girder. Second, rational layouts of struts were researched by utilizing spatial finite element method according to zero rotation in vertical girder. The 756 groups rational layout results of the above three methods with different water heads, different number of struts and different unit stiffness ratios were researched. The differences of struts stress and material dosages of various rational layout methods were evaluated. From the point of view of the forces of tainter gate struts in vertical frame, as the results shown, the layouts of struts by Chinese and American specification method, straight beam method and finite element method are large eccentric compression, small eccentric compression and axial compression respectively. The layout of struts with specification method in lower head is quite different from straight beam method and finite element method, and the layouts of deep water head with straight beam method and finite element method are tend to be consistent. Unit stiffness ratio between vertical girder and strut has little effect on layout of tainter gate struts, but has a great influence on material dosages of tainter gate. Compared with specification method, layout of tainter gate with two struts and three struts by using straight beam method and finite element method can improve stability of struts and save materials of overall tainter gate structure, and the material saving rates of tainter gate with two struts and three struts with finite element method are respectively [32.63, 47.58] (%) and [21.61, 30.01] (%). Rational layout concise charts of tainter gate with two struts and three struts by specification method, straight beam method and finite element method are given, which can be used directly for projects designs. Compared with specification method, the layout of struts of straight beam method and finite element method is not only security and economy, but also method and mechanics concept are simple, which can provide the theoretical basis for specification revision of Chinese and American.Peer Reviewe
Entropy Generation of Secondary Flow in a Turning Passage with Different Boundary Layer Characteristics
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The development of secondary flow along a curved channel is a fundamental flow phenomenon occurring in a wide range of engineering applications, including turbomachinery, aerospace, heating, ventilation, air conditioning, etc. The underlying flow physics about end-wall secondary flows has been well-documented in the open literature, while the interaction between a secondary flow and a side-wall boundary layer, which is critical to the aerothermal performance of a side-wall surface, has not been comprehensively studied. In this study, the entropy generation of secondary flow and the interaction between an end-wall passage vortex and a side-wall boundary layer were numerically investigated by Reynolds-averaged Navier–Stokes (RANS) CFD for a 90° curved channel. The transportation effect of secondary flow and the generation mechanism of an induced vortex pair on the side wall is reported. It was also found that the growth of the secondary flow can be suppressed due to the displacement effect of the side-wall boundary layer. Furthermore, it was found that the interaction between a secondary flow and a side-wall boundary layer provides a suppression effect on side-wall boundary layer separation.Peer reviewe
Efficacy and safety of PCSK9 inhibition in cardiovascular disease: a meta-analysis of 45 randomized controlled trials
Background: Safety concerns about proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors make physicians reluctant to prescribe agents for patients. The present aim was to assess the efficacy and safety of alirocumab, evolocumab and bococizumab in patients with atherosclerotic cardiovascular disease (ASCVD). Methods: Medline, the Cochrane Library and Clinicaltrials.gov were searched for 45 randomized controlled trials, involving 97,297 patients. Results: Compared with the control group, PCSK9 inhibitors could significantly reduce low-density lipoprotein cholesterol, total cholesterol, triglycerides and increase high-density lipoprotein cholesterol. Alirocumab was associated with lower incidence of unstable angina (p < 0.05) and myocardial infarction (p < 0.05), compared with the control group. Alirocumab (odds ratio [OR] 0.76, 95% confidence interval [CI] 0.60–0.97, p < 0.05), evolocumab (OR 0.79, 95% CI 0.66–0.95, p < 0.05) and bococizumab (OR 0.60, 95% CI 0.42–0.84, p < 0.05) were associated with lower incidence of stroke, compared with control group. The incidence of injection-site reactions was significantly higher in alirocumab (OR 1.68, 95% CI 1.45–1.93, p < 0.05), evolocumab (OR 1.64, 95% CI 1.41–1.91, p < 0.05) and bococizumab (OR 8.03, 95% CI 6.85–9.41, p < 0.05) group than in the control group. Conclusions: Alirocumab and evolocumab could ameliorate lipid profile and reduce the risk of cardiac disorders and stroke with satisfactory safety and tolerability. However, injection-site reactions should be paid attention to
Recommended from our members
The Vortical Structures in the Rear Separation and Wake Produced by a Supersonic Micro-Ramp
The vortical structures in the rear separation and wake region produced by a micro-ramp that immersed in a supersonic turbulent boundary layer are investigated. The small scale separation close to the trailing edge was reveled and this confirms the previous experimental observation. Between the reverse region and surrounding fast moving flow, a three-dimensional shear layer was formed, and vortices are generated. By using vortex line method, the spiral points were understood as the cross-sections of the Ω-shaped vortices that follow the shape of the separation. The vortical structure was analogous to that in the wake region, where similar Ω-shaped vortex can be observed which follows the deficit region caused by the micro-ramp. Finally, the revealed flow topology was conceived beneficial to studying the wall bounded turbulence which involves similar vortical structures but in a smaller scale, while the vortical pattern in the current micro-ramp wake is larger
Recommended from our members
LES investigation into the generation of momentum deficits in the supersonic wake of a micro-ramp
Implicitly implemented large eddy simulation (LES) with a fifth-order WENO scheme was conducted in this study. Based on Navier-Stokes equations, this LES was carried out to explore the origin of momentum deficit caused by a supersonic micro-ramp at flow conditions of M a = 2.5 and Re θ = 5760. The numerical results were validated through qualitative and quantitative comparisons with existing experimental data. After describing the aerodynamic properties of the supersonic wake, such as the deficit and the streamwise vortices, the momentum deficit was later detected to originate from the lower portion of the upstream boundary layer, while the high momentum fluid originated from close to the wall at the upper portion. Position alternation trigged by the micro-ramp was finally proposed as a revised mechanism
Recommended from our members
The multichannel discharge plasma synthetic jet actuator
The plasma synthetic jet actuator (PSJA) is a flow control device capable of generating high speed pulsed jet. However, the performance of conventional PSJA is restricted by low discharge efficiency and small control area, because one power supply only drives one electrode couple. The present work is to propose a new concept of multichannel discharge plasma synthetic jet actuator (MD-PSJA), which is driven by single power supply. The new MD-PSJA has two types, namely the multi-electrode PSJA and the multi-PSJA array. These two types of MD-PSJA are examined experimentally. The multi-electrode PSJA containing 11-electrode PSJA is first studied. Comparison with standard 2-electrode PSJA reveals that the discharge efficiency and jet velocity increase 200% and 47% respectively under the same input energy and discharge voltage. The multi-PSJA array is later evaluated. One power supply is found to be able to drive an array of 12 PSJAs, resulting in 6 times affected area and 64% jet velocity of a conventional PSJA. The proposed MD-PSJA is finally concluded an improved active flow control actuator in high speed applications
Recommended from our members
Investigation of the Vortex Ring Transition using Scanning Tomo-PIV
The transition of a vortex ring at ReΓ = 5030 is studied by time-resolved scanning tomographic PIV technique. The transition process is first analyzed through flow quantities such as circulation and vorticity components. Using the volumetric measurement technique, vortical organization of the vortex ring at early and late transition stages are visualized respectively. Focus is paid to the instability phenomenon associated with transition. The present 4D flow data allows analysis of the temporal evolution of the wavenumber spectra. The dominant wavenumbers in transition are identified and the growth of their amplitude is revealed. The vortex ring transition is finally studied through the particle trajectories. A phase difference between the axial velocity and radial velocity is found in the beginning of transition, however, it is subject to change following the progression of transition. Statistical analysis on the velocity components helps to identify the aft portion of the inner ring as the one that is first to lose the original phase relation in velocity, which is caused by the secondary vortical activity during transition
Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing
Indicine cattle, also referred to as zebu (Bos taurus indicus), play a central role in pastoral communities across a wide range of agro-ecosystems, from extremely hot semiarid regions to hot humid tropical regions. However, their adaptive genetic changes following their dispersal into East Asia from the Indian subcontinent have remained poorly documented. Here, we characterize their global genetic diversity using high-quality whole-genome sequencing data from 354 indicine cattle of 57 breeds/populations, including major indicine phylogeographic groups worldwide. We reveal their probable migration into East Asia was along a coastal route rather than inland routes and we detected introgression from other bovine species. Genomic regions carrying morphology-, immune-, and heat-tolerance-related genes underwent divergent selection according to Asian agro-ecologies. We identify distinct sets of loci that contain promising candidate variants for adaptation to hot semi-arid and hot humid tropical ecosystems. Our results indicate that the rapid and successful adaptation of East Asian indicine cattle to hot humid environments was promoted by localized introgression from banteng and/or gaur. Our findings provide insights into the history and environmental adaptation of indicine cattle
Research on rational layout of strut arms of tainter gate in vertical frame
The overall stability of hydraulic tainter steel gate decrease seriously, and they are caused by improper structure layout of the two-way eccentric compression of struts. Chinese and American specification method, structural mechanics method and finite element method are respectively used to study rational structural layout of strut arms in vertical frame. First of all, a unified method for rational layout of struts of tainter gate in vertical frame is deduced by using structural mechanics method that simplifies curve girder as straight girder on the basis of zero rotation in vertical girder. Second, rational layouts of struts were researched by utilizing spatial finite element method according to zero rotation in vertical girder. The 756 groups rational layout results of the above three methods with different water heads, different number of struts and different unit stiffness ratios were researched. The differences of struts stress and material dosages of various rational layout methods were evaluated. From the point of view of the forces of tainter gate struts in vertical frame, as the results shown, the layouts of struts by Chinese and American specification method, straight beam method and finite element method are large eccentric compression, small eccentric compression and axial compression respectively. The layout of struts with specification method in lower head is quite different from straight beam method and finite element method, and the layouts of deep water head with straight beam method and finite element method are tend to be consistent. Unit stiffness ratio between vertical girder and strut has little effect on layout of tainter gate struts, but has a great influence on material dosages of tainter gate. Compared with specification method, layout of tainter gate with two struts and three struts by using straight beam method and finite element method can improve stability of struts and save materials of overall tainter gate structure, and the material saving rates of tainter gate with two struts and three struts with finite element method are respectively [32.63, 47.58] (%) and [21.61, 30.01] (%). Rational layout concise charts of tainter gate with two struts and three struts by specification method, straight beam method and finite element method are given, which can be used directly for projects designs. Compared with specification method, the layout of struts of straight beam method and finite element method is not only security and economy, but also method and mechanics concept are simple, which can provide the theoretical basis for specification revision of Chinese and American