50 research outputs found

    Research on rational layout of strut arms of tainter gate in vertical frame

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    The overall stability of hydraulic tainter steel gate decrease seriously, and they are caused by improper structure layout of the two-way eccentric compression of struts. Chinese and American specification method, structural mechanics method and finite element method are respectively used to study rational structural layout of strut arms in vertical frame. First of all, a unified method for rational layout of struts of tainter gate in vertical frame is deduced by using structural mechanics method that simplifies curve girder as straight girder on the basis of zero rotation in vertical girder. Second, rational layouts of struts were researched by utilizing spatial finite element method according to zero rotation in vertical girder. The 756 groups rational layout results of the above three methods with different water heads, different number of struts and different unit stiffness ratios were researched. The differences of struts stress and material dosages of various rational layout methods were evaluated. From the point of view of the forces of tainter gate struts in vertical frame, as the results shown, the layouts of struts by Chinese and American specification method, straight beam method and finite element method are large eccentric compression, small eccentric compression and axial compression respectively. The layout of struts with specification method in lower head is quite different from straight beam method and finite element method, and the layouts of deep water head with straight beam method and finite element method are tend to be consistent. Unit stiffness ratio between vertical girder and strut has little effect on layout of tainter gate struts, but has a great influence on material dosages of tainter gate. Compared with specification method, layout of tainter gate with two struts and three struts by using straight beam method and finite element method can improve stability of struts and save materials of overall tainter gate structure, and the material saving rates of tainter gate with two struts and three struts with finite element method are respectively [32.63, 47.58] (%) and [21.61, 30.01] (%). Rational layout concise charts of tainter gate with two struts and three struts by specification method, straight beam method and finite element method are given, which can be used directly for projects designs. Compared with specification method, the layout of struts of straight beam method and finite element method is not only security and economy, but also method and mechanics concept are simple, which can provide the theoretical basis for specification revision of Chinese and American.Peer Reviewe

    Entropy Generation of Secondary Flow in a Turning Passage with Different Boundary Layer Characteristics

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    © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The development of secondary flow along a curved channel is a fundamental flow phenomenon occurring in a wide range of engineering applications, including turbomachinery, aerospace, heating, ventilation, air conditioning, etc. The underlying flow physics about end-wall secondary flows has been well-documented in the open literature, while the interaction between a secondary flow and a side-wall boundary layer, which is critical to the aerothermal performance of a side-wall surface, has not been comprehensively studied. In this study, the entropy generation of secondary flow and the interaction between an end-wall passage vortex and a side-wall boundary layer were numerically investigated by Reynolds-averaged Navier–Stokes (RANS) CFD for a 90° curved channel. The transportation effect of secondary flow and the generation mechanism of an induced vortex pair on the side wall is reported. It was also found that the growth of the secondary flow can be suppressed due to the displacement effect of the side-wall boundary layer. Furthermore, it was found that the interaction between a secondary flow and a side-wall boundary layer provides a suppression effect on side-wall boundary layer separation.Peer reviewe

    Efficacy and safety of PCSK9 inhibition in cardiovascular disease: a meta-analysis of 45 randomized controlled trials

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    Background: Safety concerns about proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors make physicians reluctant to prescribe agents for patients. The present aim was to assess the efficacy and safety of alirocumab, evolocumab and bococizumab in patients with atherosclerotic cardiovascular disease (ASCVD). Methods: Medline, the Cochrane Library and Clinicaltrials.gov were searched for 45 randomized controlled trials, involving 97,297 patients. Results: Compared with the control group, PCSK9 inhibitors could significantly reduce low-density lipoprotein cholesterol, total cholesterol, triglycerides and increase high-density lipoprotein cholesterol. Alirocumab was associated with lower incidence of unstable angina (p < 0.05) and myocardial infarction (p < 0.05), compared with the control group. Alirocumab (odds ratio [OR] 0.76, 95% confidence interval [CI] 0.60–0.97, p < 0.05), evolocumab (OR 0.79, 95% CI 0.66–0.95, p < 0.05) and bococizumab (OR 0.60, 95% CI 0.42–0.84, p < 0.05) were associated with lower incidence of stroke, compared with control group. The incidence of injection-site reactions was significantly higher in alirocumab (OR 1.68, 95% CI 1.45–1.93, p < 0.05), evolocumab (OR 1.64, 95% CI 1.41–1.91, p < 0.05) and bococizumab (OR 8.03, 95% CI 6.85–9.41, p < 0.05) group than in the control group. Conclusions: Alirocumab and evolocumab could ameliorate lipid profile and reduce the risk of cardiac disorders and stroke with satisfactory safety and tolerability. However, injection-site reactions should be paid attention to

    Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing

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    Indicine cattle, also referred to as zebu (Bos taurus indicus), play a central role in pastoral communities across a wide range of agro-ecosystems, from extremely hot semiarid regions to hot humid tropical regions. However, their adaptive genetic changes following their dispersal into East Asia from the Indian subcontinent have remained poorly documented. Here, we characterize their global genetic diversity using high-quality whole-genome sequencing data from 354 indicine cattle of 57 breeds/populations, including major indicine phylogeographic groups worldwide. We reveal their probable migration into East Asia was along a coastal route rather than inland routes and we detected introgression from other bovine species. Genomic regions carrying morphology-, immune-, and heat-tolerance-related genes underwent divergent selection according to Asian agro-ecologies. We identify distinct sets of loci that contain promising candidate variants for adaptation to hot semi-arid and hot humid tropical ecosystems. Our results indicate that the rapid and successful adaptation of East Asian indicine cattle to hot humid environments was promoted by localized introgression from banteng and/or gaur. Our findings provide insights into the history and environmental adaptation of indicine cattle

    Research on rational layout of strut arms of tainter gate in vertical frame

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    The overall stability of hydraulic tainter steel gate decrease seriously, and they are caused by improper structure layout of the two-way eccentric compression of struts. Chinese and American specification method, structural mechanics method and finite element method are respectively used to study rational structural layout of strut arms in vertical frame. First of all, a unified method for rational layout of struts of tainter gate in vertical frame is deduced by using structural mechanics method that simplifies curve girder as straight girder on the basis of zero rotation in vertical girder. Second, rational layouts of struts were researched by utilizing spatial finite element method according to zero rotation in vertical girder. The 756 groups rational layout results of the above three methods with different water heads, different number of struts and different unit stiffness ratios were researched. The differences of struts stress and material dosages of various rational layout methods were evaluated. From the point of view of the forces of tainter gate struts in vertical frame, as the results shown, the layouts of struts by Chinese and American specification method, straight beam method and finite element method are large eccentric compression, small eccentric compression and axial compression respectively. The layout of struts with specification method in lower head is quite different from straight beam method and finite element method, and the layouts of deep water head with straight beam method and finite element method are tend to be consistent. Unit stiffness ratio between vertical girder and strut has little effect on layout of tainter gate struts, but has a great influence on material dosages of tainter gate. Compared with specification method, layout of tainter gate with two struts and three struts by using straight beam method and finite element method can improve stability of struts and save materials of overall tainter gate structure, and the material saving rates of tainter gate with two struts and three struts with finite element method are respectively [32.63, 47.58] (%) and [21.61, 30.01] (%). Rational layout concise charts of tainter gate with two struts and three struts by specification method, straight beam method and finite element method are given, which can be used directly for projects designs. Compared with specification method, the layout of struts of straight beam method and finite element method is not only security and economy, but also method and mechanics concept are simple, which can provide the theoretical basis for specification revision of Chinese and American
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