The Resistance of Ship Web Girders in Collision and Grounding

Ship web girders play an important role in ship structure performance during collision and grounding accidents. The behavior of web girders subjected to in-plane concentrated load is investigated by numerical simulation and theoretical analysis in this paper. A numerical simulation based on previous experiment is conducted to give insight to the deformation mechanism of crushing web girders. Some new important deformation characteristics are observed through the simulation results. A new theoretical deformation model is proposed featured with these deformation characteristics, and a simplified analytical method for predicting the instantaneous and mean resistances of crushing web girders is proposed. The proposed method is verified by two previous experiments and a series of numerical simulations. The agreement between the solutions by the proposed method and the experiment results is good. The comparison results between the proposed analytical method and numerical simulation results are satisfactory for most cases. The proposed analytical method will contribute to the establishment of an efficient method for fast and reliable assessment of the outcome of ship accidental collisions and grounding events

Global Positive Periodic Solutions for Periodic Two-Species Competitive Systems with Multiple Delays and Impulses

A set of easily verifiable sufficient conditions are derived to guarantee the existence and the global stability of positive periodic solutions for two-species competitive systems with multiple delays and impulses, by applying some new analysis techniques. This improves and extends a series of the well-known sufficiency theorems in the literature about the problems mentioned previously

Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation

The blood-brain barrier (BBB) is essential for the exchange of nutrient and ions to maintain the homeostasis of central nervous system (CNS). BBB dysfunction is commonly associated with the disruption of endothelial tight junctions and excess permeability, which results in various CNS diseases. Therefore, maintaining the structural integrity and proper function of the BBB is essential for the homeostasis and physiological function of the CNS. Here, we showed that serum starvation disrupted the function of endothelial barrier as evidenced by decreased trans-endothelial electrical resistance, increased permeability, and redistribution of tight junction proteins such as Claudin-5 (Cldn5). Further analyses revealed that autophagy was activated and protected the integrity of endothelial barrier by scavenging ROS and inhibiting the redistribution of Cldn5 under starvation, as evidenced by accumulation of autophagic vacuoles and increased expression of LC3II/I, ATG5 and LAMP1. In addition, autophagosome was observed to package and eliminate the aggregated Cldn5 in cytosol as detected by immunoelectron microscopy (IEM) and stimulated emission depletion (STED) microscope. Moreover, Akt-mTOR-p70S6K pathway was found to be involved in the protective autophagy induced by starvation. Our data demonstrated that autophagy played an essential role in maintaining the integrity of endothelial barrier by regulating the localization of Cldn5 under starvation

Fabrication of (Mn,Co)3O4 Surface Coatings onto Alloy Substrates

Ferritic stainless steels are promising candidates for IT-SOFC interconnect applications due to their low cost and resistance to oxidation at SOFC operating temperatures. However, several challenges remain, including long term electrical conductivity and surface stability under interconnect exposure conditions and chromia scale evaporation. One means of extending interconnect lifetime and improving performance is to apply a protective coating, such as (Mn,Co)3O4 spinel, to the cathode side of the interconnect. These coatings have proven effective in reducing scale growth kinetics and Cr volatility. This report describes several procedures developed at PNNL for fabricating (Mn,Co)3O4 spinel coatings onto ferritic stainless steels

Cycle Encoding of a StyleGAN Encoder for Improved Reconstruction and Editability

GAN inversion aims to invert an input image into the latent space of a pre-trained GAN. Despite the recent advances in GAN inversion, there remain challenges to mitigate the tradeoff between distortion and editability, i.e. reconstructing the input image accurately and editing the inverted image with a small visual quality drop. The recently proposed pivotal tuning model makes significant progress towards reconstruction and editability, by using a two-step approach that first inverts the input image into a latent code, called pivot code, and then alters the generator so that the input image can be accurately mapped into the pivot code. Here, we show that both reconstruction and editability can be improved by a proper design of the pivot code. We present a simple yet effective method, named cycle encoding, for a high-quality pivot code. The key idea of our method is to progressively train an encoder in varying spaces according to a cycle scheme: W->W+->W. This training methodology preserves the properties of both W and W+ spaces, i.e. high editability of W and low distortion of W+. To further decrease the distortion, we also propose to refine the pivot code with an optimization-based method, where a regularization term is introduced to reduce the degradation in editability. Qualitative and quantitative comparisons to several state-of-the-art methods demonstrate the superiority of our approach

Divergence of exonic splicing elements after gene duplication and the impact on gene structures

An analysis of human exonic splicing elements in duplicated genes reveals their important role in the generation of new gene structures