Some Remarks on the Final State Interactions in B→πKB\to \pi K Decays

Careful discussions are made on some points which are met in studying B decay final state interactions, taking the $B^0\to \pi^+ K^-$ process as an example. We point out that $\pi$--exchange rescatterings are not important, whereas for $D^*$ and $D^{**}$ exchanges, since the $B^0\to D^+D_s^-$ decay has a large branching ratio their contributions may be large enough to enhance the $B\to \pi K$ branching ratio significantly. However our estimates fail to predict a large enhancement.Comment: 5 pages, use elsart.sty; The previous version is erroneous in explaining the "charm peguin" effects. No large enhancement to $B\to \pi K$ is found through $D^+D_s^-$ intermediate stat

Quantitative profiling of BATF family proteins/JUNB/IRF hetero-trimers using Spec-seq

Additional file 6. Half site analysis for BATFx-JUNB-IRFx. (A) Single variants from half sites of these oligos in the library were used to generate energy logos. Bolded positions represent the half sites generated in B. (B) Energy logos from Spec-seq results of BATFx-JUNB-IRFx. The Y-axis is negative energy so the preferred sequence is on the top

Five Cases of Pre-operative radiotherapy for Primary huge liver cancer

目的  评价巨大肝癌患者术前放疗采用全肝移动条野放疗、缩野技术和分阶段放疗，剂量递增至60Gy的移动条野放射综合治疗方案的长期随访疗效。方法:回顾性分析1987年9月～1993年8月江门市中心医院巨大肝癌5例术前放疗采用全肝移动条野放射18～36Gy控制亚临床病灶，再缩野对准原发病灶，放射剂量递增至50～60Gy。待原发病灶明显缩小后，利于二期切除。结果  长期随访至2014年5月，5年生存率100%，10年生存率40%，20年生存率40%，最长生存期27年无瘤健在。结论  术前放疗长期临床实践首次发现了传统放疗和三维适形放疗概念所未知的事实:⑴国际上首次报道经长期随访的巨大肝癌术前放疗，采用全肝移动条野放疗18～36Gy、缩野技术和分阶段放疗，剂量递增至50~60Gy的移动条野放射综合治疗方案，安全有效，肿瘤由大变小，其缩小率57.1%～72.2%(平均62.45%)，二期切除术顺利，放疗周期从94天～153天(平均124天)完成，治疗周期适当，长期随访疗效令人鼓舞，最长生存期27年，健在无复发。⑵病理检查  5例均为肝细胞癌，肿瘤组织呈大片坏死并有明显的纤维化，伴纤维包膜形成，镜下均见有残癌细胞。提示巨大肝癌放疗60Gy未能根治，尚有残癌细胞，说明二期手术切除的重要性。⑶移动条野技术理论详细阐明移动条野放射杀癌原理，有其本身的适应证对肿瘤边界在影像学上无法确认者，提高肿瘤的生物效应，改善正常组织的耐受量为全肝移动条野放疗30Gy，局部缩野剂量递增至60Gy的应用价值，正是移动条野技术的优点。⑷病例少，是当前能治疗肝癌亚临床病灶的新技术，有值得探索的一丝曙光，期待有关学者组织多中心循证深入研究。Objective: To evaluate the long-term effect of preoperative radiotherapy, performed by moving strip fields radiation of the whole liver, then shrinking field technique and phased radiotherapy, 60Gy dose escalation, for massive liver cancer. Methods: From September 1987 to August 1993, 5 cases with massive liver cancer in Jiangmen central hospital were retrospectively analyzed. They were treated by preoperative radiotherapy with moving strip fields radiation of the whole liver of 18~36Gy to control subclinical lesions, and then shrink the primary lesion, with dose escalation to 50~60Gy. After the primary lesion was significantly reduced, two-step resection can be performed more easily. Results: Long-term follow-up to May 2014, 5-,10-,20-year survival rates were 100%, 40% and 40%,respectively. The longest disease-free survival time was 27 years. Conclusions: Long-term clinical practice of preoperative radiotherapy for the first time discovered four unknown facts of traditional radiotherapy and Three-dimensional conformal radiotherapy:⑴It was the International first report of massive liver cancer preoperative radiotherapy, performed by 18~36Gy dose of moving strip fields radiation of the whole liver, then shrinking field technique and phased radiotherapy, 50~60Gy dose escalation. And it was proved to be effective and safe, by the reduction rate from 57.1% to 72.2% (average 62.45%), two phase successful resection, radiotherapy lasted from 94 days to 153 days (mean 124 days). Long-term efficacy is encouraging. The longest survival time was 27 years, alive without recurrence.⑵Pathology: 5 cases were hepatocellular carcinoma, large areas of necrosis and tumor tissue showed significant fibrosis, with fibrous capsule formation, microscopic residual cancer cells were seen there. It showed that 60Gy dose of radiotherapy failed to cure massive liver cancer, there are residual cancer cells, which indicating the importance of the second-phase surgery.⑶Moving strip technique elaborated the theory of moving into the wild shot carcinoma principle, and its own indications were those who unable to confirm the boundaries of the tumor on imaging, to improve the biological effects of cancer and improve the tolerance of normal liver tissue for with moving strip fields radiation of the whole liver by dose of 30Gy, partially reduced fields to 60Gy dose escalation. It is the advantage of technology of moving strip field.⑷There were few cases for now. It was a new treatment for liver subclinical lesions, and it worth more research conducted by scholars and multi-center evidence-based organizations