Performance evaluation of the 8-inch MCP-PMT for Jinping Neutrino Experiment

Jinping Neutrino Experiment plans to deploy a new type of 8-inch MCP-PMT with high photon detection efficiency for MeV-scale neutrino measurements. This work studies the performance of the MCP-PMTs, including the photon detection efficiency, the charge resolution of the single photoelectron, the transition time spread, single photoelectron response, rates of dark counts and after pulses. We find a long tail in the charge distribution, and combined with the high photon detection efficiency, the overall energy resolution sees substantial improvements. Those results will be provided as the inputs to detector simulation and design. Our results show that the new PMT satisfies all the requirements of the Jinping Neutrino Experiment

Treatment of Huge Hepatocellular Carcinoma Using Cinobufacini Injection in Transarterial Chemoembolization: A Retrospective Study

The aim of this study is to examine the safety and efficacy of Cinobufacini injection in transarterial chemoembolization (TACE) for treatment of huge hepatocellular carcinoma (HCC). Clinical data of 56 consecutive patients with HCC larger than 10 cm who had been treated with TACE between December 2010 and August 2014 were retrospectively analyzed. Among these patients, 31 belonged to the Cinobufacini group and 25 belonged to the epirubicin group. The clinical efficacy, survival time, and adverse events in patients in the two groups were compared. The objective response rate in the Cinobufacini group was significantly higher than that in the epirubicin group (53.6% versus 23.1%, = 0.022). The median survival time (10.6 versus 14.1 months, 2 = 0.092, = 0.762) and the median time to progression (4.9 versus 5.7 months, 2 = 0.097, = 0.756) were similar between the groups. The incidence rate of adverse events was lower in the Cinobufacini group than in the epirubicin group ( < 0.05). The short-term clinical efficacy of Cinobufacini is better than that of epirubicin in TACE for treating huge HCC, while their long-term clinical efficacy is similar. However, lower incidence of adverse events was noted in TACE using Cinobufacini rather than epirubicin

CMTM2 is essential for spermiogenesis in mice

Objective: This study is to investigate whether CKLF-like MARVEL transmembrane domain-containing protein 2 (CMTM2) is involved in spermatogenesis in mice. CMTM2 is highly expressed in testis, and could possibly a potential spermagogenesis specific gene. Methods: CMTM2-deficient mouse model was generated. Northern, RT-PCR and Western blotting analysis were performed on total RNA derived from wild-type (WT, CMTM2(+/+)) and CMTM2(+/-)(heterozygote) and CMTM2(-/-)(homozygote) mice to examine the CMTM2 level. The number of litters and the number of pups were counted and pregnancy rates calculated. The motility and morphology of the sperm and the histology of testes were analyzed. Serum testosterone and FSH concentrations were also measured. Standard t-tests (Excel, Microsoft, Redmond, WA, USA) were used and standard error of means were calculated. Results: CMTM2 is highly expressed in a finely regulated pattern in the mouse testis during spermatogenesis. The body weight of adult mice with CMTM2 deficiency was not significantly different from that of wild type mice. No obvious anatomical or behavioral abnormalities were observed. The testes of CMTM2(-/-)were smaller than that of CMTM2(+/+) mice. Female CMTM2 null mice are fertile, indicating that CMTM2 is not required for female gametogenesis. The CMTM2(-/-)mice produced virtually no sperm, and CMTM2(+/-)mice sperm count showed a significant decline. The hormone levels are not significantly different. The CMTM2(-/-)male mice are sterile due to a late, complete arrest of spermiogenesis. The organized architecture of the seminiferous epithelium of the seminiferous tubules seen in CMTM2(+/+) mice was lost in CMTM2(-/-)mice. Conclusions: This study suggests CMTM2 is not required for embryonic development in the mouse but is essential for spermiogenesis.NIH [AG14875]; Specialized Research Fund for the Doctoral Program of Higher Education, China [20-120001120056]SCI(E)[email protected]

Frequency-Synthesized Approach to High-Power Attosecond Pulse Generation and Applications: Generation and Diagnostics

We present a new scheme of generating high-power attosecond pulses and arbitrary waveform synthesis by multicolor synthesis. The full bandwidth of the multicolor laser system extends more than two-octaves and reaches 37,600 cm−1 which can be used to generate sub-single-cycle (∼0.37 cycle) sub-femtosecond (360 attosecond) pulses with carrier-envelope phase (CEP) control. The results show a promising approach for generation of relatively high-power attosecond pulses in the optical region. In this chapter, the design and diagnostics of the laser system are described. In part 2 of this work (the following chapter), we demonstrate selected applications of this novel source, such as coherently controlled harmonic generation as well as phase-sensitive 2-color ablation of copper and stainless steel by this multi-color laser system

Location-Enabled IoT (LE-IoT): A Survey of Positioning Techniques, Error Sources, and Mitigation

The Internet of Things (IoT) has started to empower the future of many industrial and mass-market applications. Localization techniques are becoming key to add location context to IoT data without human perception and intervention. Meanwhile, the newly-emerged Low-Power Wide-Area Network (LPWAN) technologies have advantages such as long-range, low power consumption, low cost, massive connections, and the capability for communication in both indoor and outdoor areas. These features make LPWAN signals strong candidates for mass-market localization applications. However, there are various error sources that have limited localization performance by using such IoT signals. This paper reviews the IoT localization system through the following sequence: IoT localization system review -- localization data sources -- localization algorithms -- localization error sources and mitigation -- localization performance evaluation. Compared to the related surveys, this paper has a more comprehensive and state-of-the-art review on IoT localization methods, an original review on IoT localization error sources and mitigation, an original review on IoT localization performance evaluation, and a more comprehensive review of IoT localization applications, opportunities, and challenges. Thus, this survey provides comprehensive guidance for peers who are interested in enabling localization ability in the existing IoT systems, using IoT systems for localization, or integrating IoT signals with the existing localization sensors

Altered myocardial response in patients with diabetic retinopathy: an exercise echocardiography study

Additional file 1. Multivariable analysis for individual echocardiography parameters

Evaluating the comfort of thermally dynamic wearable devices

Thermal discomfort is a widespread problem in the built environment, due in part to the variability of individual occupants’ thermal preferences. Personal comfort systems (PCS) address this individual variability, and also enable more energy-efficient thermal conditioning in buildings by reducing the need for tight indoor temperature control. This study evaluates a novel approach to PCS that leverages the time-dependence of human thermal perception. A 6.25 cm2 wearable device, Embr Wave, delivers dynamic waveforms of cooling or warming to the inner wrist. In three thermal comfort tests conducted in a climate chamber with N = 49 subjects and temperatures between 20 and 28 ºC, the device exhibited a corrective potential of 2.5 ºC within 3 minutes for both warm and cool populations, while consuming ~1 W of power. The effect is even more pronounced (corrective potential up to 3.3 ºC over periods of 3- and 45-minutes) when subjects are given control of the device’s operation. Subjects are found to optimize the device settings for pleasantness, not for the intensity of sensation. These results indicate that this low-power, wearable device improves whole-body thermal sensation, comfort, and pleasantness. It is an appropriate tool for addressing the problem of thermal discomfort in moderate indoor environments