25 research outputs found

    Simple Enantioselective Total Synthesis of Glabrescol, a Chiral C

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    Simple Total Synthesis of the Pentacyclic C

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    A 0.5–1.1-V Adaptive Bypassing SAR ADC Utilizing the Oscillation-Cycle Information of a VCO-Based Comparator

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    Linking ECMWF 2 m Temperature Forecast Errors with Upper-Level Circulation Situation: A Case-Study for China

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    Using the observational data and the forecast and reanalysis data from the European Centre for Medium-Range Weather Forecasts (ECMWF) during 2015–2018, the temporal and spatial distribution characteristics of the 2 m temperature forecast errors of ECMWF in China, as well as their attribution to upper-level circulation, are analyzed. Results show that positive 2 m temperature forecast errors mainly occur in northwestern, northern and northeastern China, and gradually increase from January to December. This kind of error is attributed to the circulation errors associated with the circumfluence of the low-level differential winds along the Mongolian Plateau, and influenced by the changes in the mid-latitude trough and ridge with the seasons. In contrast, the negative 2 m temperature forecast errors mainly occur in the southeastern part of the Qinghai-Tibet Plateau, with the largest errors around March and October, and the smallest errors around June and December. This kind of error is associated with a series of cyclonic and anticyclonic differential circulations generated by the detouring of the mid-level differential winds along the terrain near the south side of the Plateau. The positions and intensity of these differential circulations are also influenced by the variation in the mid-level circulation with the seasons

    AMS Radiocarbon Dating of an Ancient Pottery Workshop in Hepu County, China

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    International audienceAn ancient pottery workshop belonging to the Han Dynasty was excavated in Caoxie village, Hepu County. Caoxie village is an important archaeological site in Hepu County, Beihai City, in south China's Guangxi Zhuang Autonomous Region. It is believed that Hepu County was the oldest departure point on the ancient maritime trading route during the Han Dynasty (206 BC to AD 220) due to the ideal natural geographical conditions and the existence of a large number of Han tombs. Radiocarbon measurements on wood and charcoal samples from the Caoxie village site were performed at the Peking University AMS facility (PKU-AMS), Beijing, and the Centre for Isotopic Research for Cultural and Environmental Heritage (CIRCE) at Naples Second University, Italy. Calibrated ages were obtained with code CALIB 5 (Stuiver and Reimer 1993). The results of these measurements are presented and the related chronology is discussed

    Bichromatic Imaging with Hemicyanine Fluorophores Enables Simultaneous Visualization of Non-alcoholic Fatty Liver Disease and Metastatic Intestinal Cancer

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    Simultaneous detection of different diseases via a single fluorophore is challenging. We herein report a bichromatic fluorophore named Cy-914 for the simultaneous diagnosis of non-alcoholic fatty liver disease (NAFLD) and metastatic intestinal cancer by leveraging its NIR-I/NIR-II dual-color imaging capability. Cy-914 with a pKa of 6.98 exhibits high sensitivity to pH and viscosity, showing turn-on NIR-I fluorescence at 795 nm in an acidic tumor microenvironment, meanwhile displaying intense NIR-II fluorescence at 914/1030 nm under neutral to slightly basic viscous conditions. Notably, Cy-914 could sensitively and noninvasively monitor viscosity variations in the progression of NAFLD. More importantly, it was able to simultaneously visualize NAFLD (ex/em = 808/1000–1700 nm) and intestinal metastases (ex/em = 570/810–875 nm) in two independent channels without spectral cross interference after topical spraying, further improving fluorescence-guided surgery of tiny metastases less than 3 mm. This strategy may provide an understanding for developing multi-color fluorophores for multi-disease diagnosis
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