A Swarm-based Dynamic Evacuation Simulation Model Under the Background of Secondary Disasters

AbstractDue to the occurrence of secondary disasters in disaster relief, a swarm-based dynamic disaster evacuation simulation model is established to settle the practical difficulties of reducing efficiency in evacuation. And much better simulation results have been achieved than static plans or disorganized autonomous escape scheme. Simulation results show that “to changing the status quo” dynamic evacuation plan is much better than “maintaining the status quo,” the static and self-evacuation plan or autonomous escape behavior for emergency evacuation, especially those with secondary disasters

Clinical analysis of vitrectomy in treatment of 48 eyes with metallic foreign bodies

AIM: To investigate the effect of vitrectomy in treatment of metal intraocular foreign bodies and the factors affecting visual prognosis.<p>METHODS:Fourty seven cases(48 eyes)with foreign bodies from January 2010 to June 2013 in our hospital underwent vitrectomy combined with intraocular foreign body removal were retrospectively analyzed. The changes of visual acuity, the size of foreign body, the complications of preoperative, and the relationship between treatment time and visual acuity were recorded. <p>RESULTS: Totally 46 eyes were successfully removed the complete foreign body, 2 eyes of orbital foreign bodies had not been removed. After 6mo of followed-up, the best corrected visual acuity were all improved in varying degrees(<i>P</i><0.05), intraocular foreign body size combined with retinal detachment was the risk factor for visual impact(<i>P</i><0.05).<p>CONCLUSION:Vitrectomy has obvious advantages in the treatment of metal intraocular foreign bodies. Timely and appropriate vitrectomy is very important to the recovery of visual function

Mesenchymal stem cells-derived exosomal miR-653-5p suppresses laryngeal papilloma progression by inhibiting BZW2

Objectives: Although miR-653-5p has been validated to participate in the progression of multiple types of cancer, the functional role of exosomal miR-653-5p derived from Mesenchymal Stem Cells (MSCs) in Laryngeal Papilloma (LP) has still remained elusive. Hence, this study aimed to investigate the role of MSCs-derived exosomal miR-653-5p in LP. Methods: LP tissues (n&nbsp;=&nbsp;15) and adjacent normal tissues (n&nbsp;=&nbsp;10) were collected to examine the expression level of miR-653-5p. The expression level of miR-653-5p in LP cells and normal cells was also detected. Then, miR-653-5p was overexpressed or silenced to explore its effects on the proliferation, migration, invasion, and apoptosis of LP cells. Thereafter, the effects of exosomal miR-653-5p derived from MSCs on LP cell progression and the potential regulatory mechanism of miR-653-5p were assessed. Results: It was revealed that the expression level of miR-653-5p was downregulated in LP tissues and cells. In addition, miR-653-5p suppressed the proliferation, migration, invasion, and apoptosis of LP cells. Exosomes derived from MSCs played a suppressive role in LP development and mediated the transmission of miR-653-5p to LP cells. Further exploration identified Basic leucine Zipper and W2 domains&nbsp;2 (BZW2) as the target of miR-653-5p. More importantly, the rescue experiments revealed that MSCs-secreted exosomal miR-653-5p efficiently inhibited the aggressive phenotypes of LP cells, which could be significantly reversed by BZW2 overexpression in LP cells. Conclusion: MSCs-derived exosomal miR-653-5p exerted inhibitory effects on LP progression through targeting BZW2, which provided a novel idea for the therapy of LP. Clinical Trial registration number: chictr-ior-17011021

Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes

<p>Abstract</p> <p>Background</p> <p>Glucose variability is one of components of the dysglycemia in diabetes and may play an important role in development of diabetic vascular complications. The objective of this study was to assess the relationship between glycemic variability determined by a continuous glucose monitoring (CGM) system and the presence and severity of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM).</p> <p>Methods</p> <p>In 344 T2DM patients with chest pain, coronary angiography revealed CAD (coronary stenosis ≥ 50% luminal diameter narrowing) in 252 patients and 92 patients without CAD. Gensini score was used to assess the severity of CAD. All participants' CGM parameters and biochemical characteristics were measured at baseline.</p> <p>Results</p> <p>Diabetic patients with CAD were older, and more were male and cigarette smokers compared with the controls. Levels of the mean amplitude of glycemic excursions (MAGE) (3.7 ± 1.4 mmol/L vs. 3.2 ± 1.2 mmol/L, p < 0.001), postprandial glucose excursion (PPGE) (3.9 ± 1.6 mmol/L vs. 3.6 ± 1.4 mmol/L, p = 0.036), serum high-sensitive C-reactive protein (hs-CRP) (10.7 ± 12.4 mg/L vs. 5.8 ± 6.7 mg/L, p < 0.001) and creatinine (Cr) (87 ± 23 mmol/L vs. 77 ± 14 mmol/L, p < 0.001) were significantly higher in patients with CAD than in patients without CAD. Gensini score closely correlated with age, MAGE, PPGE, hemoglobin A_1c(HbA_1c), hs-CRP and total cholesterol (TC). Multivariate analysis indicated that age (p < 0.001), MAGE (p < 0.001), serum levels of HbA_1c(p = 0.022) and hs-CRP (p = 0.005) were independent determinants for Gensini score. Logistic regression analysis revealed that MAGE ≥ 3.4 mmol/L was an independent predictor for CAD. The area under the receiver-operating characteristic curve for MAGE (0.618, p = 0.001) was superior to that for HbA_1c(0.554, p = 0.129).</p> <p>Conclusions</p> <p>The intraday glycemic variability is associated with the presence and severity of CAD in patients with T2DM. Effects of glycemic excursions on vascular complications should not be neglected in diabetes.</p

Occ3D: A Large-Scale 3D Occupancy Prediction Benchmark for Autonomous Driving

Robotic perception requires the modeling of both 3D geometry and semantics. Existing methods typically focus on estimating 3D bounding boxes, neglecting finer geometric details and struggling to handle general, out-of-vocabulary objects. 3D occupancy prediction, which estimates the detailed occupancy states and semantics of a scene, is an emerging task to overcome these limitations. To support 3D occupancy prediction, we develop a label generation pipeline that produces dense, visibility-aware labels for any given scene. This pipeline comprises three stages: voxel densification, occlusion reasoning, and image-guided voxel refinement. We establish two benchmarks, derived from the Waymo Open Dataset and the nuScenes Dataset, namely Occ3D-Waymo and Occ3D-nuScenes benchmarks. Furthermore, we provide an extensive analysis of the proposed dataset with various baseline models. Lastly, we propose a new model, dubbed Coarse-to-Fine Occupancy (CTF-Occ) network, which demonstrates superior performance on the Occ3D benchmarks. The code, data, and benchmarks are released at https://tsinghua-mars-lab.github.io/Occ3D/.Comment: Accepted to NeurIPS 202

3a,11b-Dihydr­oxy-2-oxo-2,3,3a,11b-tetra­hydro-1H-imidazo[4,5-f][1,10]phenanthrolin-7-ium chloride

In the crystal structure of the title compound, C13H11N4O3 +·Cl−, the dihedral angle between the two pyridine rings is 9.72 (9) Å. Ions are linked via N—H⋯Cl, O—H⋯Cl and O—H⋯O hydrogen bonds, forming a three-dimensional framework

A new 3-D multi-fluid model with the application in bubble dynamics using the adaptive mesh refinement

Violent pulsating bubbles behave diversely in different circumstances. It is a multi-scale problem in both space and time. In 3-D problems, the numerical simulation is usually too expensive to implement in practice with a fixed grid. In this paper, a 3-D multi-fluid model is established based on the Eulerian finite element method and the adaptive mesh refinement technique to investigate the bubble evolution and its toroidal motion near a solid vertical wall. The mixture formula for compressible multi-fluid flow is adopted to ensure conservativeness. By means of the block-based adaptive mesh refinement, the accuracy and the efficiency of the simulation are well balanced. The present model is validated by comparing the results with an underwater explosion experiment and the existing numerical results. The results agree well and a fast convergence is observed. Then, several cases with different buoyancy parameters are simulated, and the toroidal bubble motion and their pressure load on the solid wall are analyzed. The bubble's motion exhibits complex physics, such as the formation of the crescent-shaped bubble, the air cushion effect during the jet penetration, and the nonlinear relationship between the jet impact pressure and the angle between the jet and the opposite bubble surface

ANTI-DIABETIC EFFECTS OF ZHUODUQING FORMULA, A CHINESE HERBAL DECOCTION, ON A RAT MODEL OF TYPE 2 DIABETES

Background: Zhuoduqing formula (ZDQ) is a Chinese herbal decoction and used to treat type 2 diabetes in clinical practice, but the potential evidence needs to be provided. Materials and Methods: Type 2 diabetic model rats were induced by feeding high fat diet (HFD) and intraperitoneal injection of streptozotocin (STZ). The model rats were given ZDQ for 4 weeks. Insulin sensitivity was evaluated by homeostasis model assessment of basal insulin resistance (HOMA-IR) and intraperitoneal glucose tolerance test (IPGTT). Blood insulin and tumour necrosis factor-α (TNF-α) levels as well as SOCS-3 levels in skeletal muscles were analyzed by ELISA. Results: ZDQ significantly decreased fasting blood glucose, ameliorated HOMA-IR and IPGTT, and reduced triglyceride and total cholesterol in type 2 diabetic rats. Moreover, ZDQ remarkably lowered blood TNF-α levels and inhibited SOCS-3 levels in skeletal muscles. Conclusion: The results display that ZDQ performs anti-diabetic functions in type 2 diabetic rats induced by feeding HFD and intraperitoneal injection of STZ