Research on the Application of Value Creation of Big Data in Smart Tourism

Against the background of the new era, the rapid progress of information science and technology represented by big data, cloud computing and Internet of things promotes the intelligent transformation of tourism industry. Based on the technical support of big data, it integrates tourism resources to generate value creation and apply it in smart tourism, and promotes the optimization and innovation of tourism at the level of marketing, service and management. In the context of informatization, the implementation of smart tourism has become the only way for the development of the tourism industry (Dai, P. ,2015). However, the application of big data in smart tourism also faces such problems as dense and miscellaneous information data, uneven level of information technology, lack of smart tourism big data professionals, and privacy data security (Yang, X.,2015). This paper discusses the development status and future direction of smart tourism in the context of big data, so as to boost the steady development of smart tourism relying on big data platform

MiR-10b alleviates high glucose-induced human retinal endothelial cell injury by regulating TIAM1 signaling

Purpose: To investigate the effects of microRNA (miR)-10b on high glucose (HG)-induced human retinal endothelial cell (HREC) injury and the mechanisms involved.Methods: Levels of miR-10b were measured in HRECs using quantitative reverse transcriptasepolymerase chain reaction (qRT-PCR) after the addition of glucose (5.5 and 30 mM). Cell viability was measured using Cell Counting Kit-8 assay, while levels of reactive oxygen species (ROS) weredetermined using fluorimetry. An enzyme-linked immunosorbent assay (ELISA) was used to measure cellular apoptosis. Luciferase reporter assay was used to validate the miR-10b-binding sites of target genes. The levels of T-cell lymphoma invasion and metastasis (TIAM1) and NADPH oxidase-2 (NOX2) were determined using qRT-PCR. Ras-related C3 botulinum toxin substrate 1 (Rac1) activation was evaluated using a pull-down assay. The protein levels of TIAM1 and Rac1 were assayed by western blotting.Results: After HG stimulation, miR-10b expression was downregulated. Viability of HRECs decreased, whereas ROS production increased. However, the overexpression of miR-10b inhibited apoptosis and ROS production in HG-treated HRECs (p < 0.05), while luciferase reporter analysis revealed a possible binding site for miR-10b to target the 3'-untranslated region (UTR) of TIAM1. In addition, the overexpression of miR-10b distinctly reduced the expression levels of TIAM1 and NOX2, but decreased the activation of Rac1 in HG-treated HRECs (p < 0.05); these inhibitory effects of miR-10b were significantly reversed after TIAM1 application.Conclusion: MiR-10b alleviates HG-induced HREC injury by regulating TIAM1 signaling. MiR-10b therapy is a potential therapeutic strategy for patients suffering from diabetic retinopathy. Keywords: MicroRNA-10b, Human retinal endothelial cells, High glucose, TIAM1-Rac1 axi

Retracted: MiR-10b alleviates high glucose-induced human retinal endothelial cell injury by regulating TIAM1 signaling

This article previously published in Volume 19 Issue 8 of this journal in August 2020 has been retracted in line with the guidelines from the Committee on Publication Ethics (COPE, http://publication ethics.org/resources/guidelines).Retraction: Chen Y, Zhu Y, Zhao S. MiR-10b alleviates high glucose-induced human retinal endothelial cell injury by regulating TIAM1 signaling. Trop J Pharm Res, 2020, 19(8): 1577-1583.To the editor:I am retracting this article because some of the results we presented are irreproducible.Signed: Sheng Zha

Design of GPS Information Processing System Based on Single Chip Microcomputer

With the rapid development of science and technology in the 21st century, the Global Positioning System (GPS) has become one of the representatives of the development achievements of this era. The system not only has high precision and good performance, but also has a wide range of application. It has been widely used in land, ocean, space and other fields, with a very high market share. In response to a surge in demand for satellite-positioning and navigation applications, In this paper, the GPS information processing system is constructed with hardware modules such as GPS receiving module and LCD module as the main structure, single chip microcomputer as the core controller, supplemented by necessary peripheral circuits. The success of GPS information processing system based on single chip microcomputer solves the problem of high price of GPS devices in the market. In general, the design structure is not only modular and easy to carry, the most important is the human nature, cost-effective, and has great practical value

Energy-Efficient Non-Orthogonal Transmission under Reliability and Finite Blocklength Constraints

This paper investigates an energy-efficient non-orthogonal transmission design problem for two downlink receivers that have strict reliability and finite blocklength (latency) constraints. The Shannon capacity formula widely used in traditional designs needs the assumption of infinite blocklength and thus is no longer appropriate. We adopt the newly finite blocklength coding capacity formula for explicitly specifying the trade-off between reliability and code blocklength. However, conventional successive interference cancellation (SIC) may become infeasible due to heterogeneous blocklengths. We thus consider several scenarios with different channel conditions and with/without SIC. By carefully examining the problem structure, we present in closed-form the optimal power and code blocklength for energy-efficient transmissions. Simulation results provide interesting insights into conditions for which non-orthogonal transmission is more energy efficient than the orthogonal transmission such as TDMA.Comment: accepted by IEEE GlobeCom workshop on URLLC, 201

Herb-resistant UPEC strains have different biofilm formation abilities and different expression of certain biofilm related genes

Background: The mechanisms and patterns of drug resistances of E. coli strains that cause uncomplicated urinary tract infections (UTIs) vary considerably. The emerging herbresistance of uropathogenic Escherichia coli (UPEC) has been a serious health problem, yet with unknown underlying mechanisms.Methods: To explore the potential herb-resistance mechanisms of E. coli strains that cause uncomplicated UTIs, three clinically isolated herb-resistant UPEC strains (1351, 4996, 5028) were analyzed for their abilities to form biofilms and the expressions of the pga ABCD and luxS genes.Results: We found that the expression of pgaA and pgaB are very different between 1351 and 5028, and the loss-offunction of luxS in 4996 has impact on biofilm formation.Conclusions: 1. Herb-resistance of the strains is related to their abilities of biofilm formation. 2. Biofilm formation capabilities of herb-resistant strains show different responses to the presence of glucose. 3. luxS encoded AI-2 is not essential for biofilm formation in this strain but may help with more biofilm formation.Keywords: Herb-resistance; Biofilm formation; Uropathogenic Escherichia coli (UPEC); pga ABCD; lux

Structural and functional abnormities of amygdala and prefrontal cortex in major depressive disorder with suicide attempts

Finding neural features of suicide attempts (SA) in major depressive disorder (MDD) may be helpful in preventing suicidal behavior. The ventral and medial prefrontal cortex (PFC), as well as the amygdala form a circuit implicated in emotion regulation and the pathogenesis of MDD. The aim of this study was to identify whether patients with MDD who had a history of SA show structural and functional connectivity abnormalities in the amygdala and PFC relative to MDD patients without a history of SA. We measured gray matter volume in the amygdala and PFC and amygdala-PFC functional connectivity using structural and functional magnetic resonance imaging (MRI) in 158 participants [38 MDD patients with a history of SA, 60 MDD patients without a history of SA, and 60 healthy control (HC)]. MDD patients with a history of SA had decreased gray matter volume in the right and left amygdala (F = 30.270, P = 0.000), ventral/medial/dorsal PFC (F = 15.349, P = 0.000), and diminished functional connectivity between the bilateral amygdala and ventral and medial PFC regions (F = 22.467, P = 0.000), compared with individuals who had MDD without a history of SA, and the HC group. These findings provide evidence that the amygdala and PFC may be closely related to the pathogenesis of suicidal behavior in MDD and implicate the amygdala-ventral/medial PFC circuit as a potential target for suicide intervention