Frequency-mixed Single-source Domain Generalization for Medical Image Segmentation

The annotation scarcity of medical image segmentation poses challenges in collecting sufficient training data for deep learning models. Specifically, models trained on limited data may not generalize well to other unseen data domains, resulting in a domain shift issue. Consequently, domain generalization (DG) is developed to boost the performance of segmentation models on unseen domains. However, the DG setup requires multiple source domains, which impedes the efficient deployment of segmentation algorithms in clinical scenarios. To address this challenge and improve the segmentation model's generalizability, we propose a novel approach called the Frequency-mixed Single-source Domain Generalization method (FreeSDG). By analyzing the frequency's effect on domain discrepancy, FreeSDG leverages a mixed frequency spectrum to augment the single-source domain. Additionally, self-supervision is constructed in the domain augmentation to learn robust context-aware representations for the segmentation task. Experimental results on five datasets of three modalities demonstrate the effectiveness of the proposed algorithm. FreeSDG outperforms state-of-the-art methods and significantly improves the segmentation model's generalizability. Therefore, FreeSDG provides a promising solution for enhancing the generalization of medical image segmentation models, especially when annotated data is scarce. The code is available at https://github.com/liamheng/Non-IID_Medical_Image_Segmentation

Advances in the Synthesis of Halide Perovskite Single Crystals for Optoelectronic Applications

Yan J, Li H, Aldamasy MH, et al. Advances in the Synthesis of Halide Perovskite Single Crystals for Optoelectronic Applications. Chemistry of Materials. 2023;35(7):2683-2712.Perovskite materials have attracted much attention in various optoelectronics applications such as solar cells, light-emitting diodes, and photodetectors. Compared to multicrystalline films, single crystal perovskites are free of grain boundaries and exhibit lower defect density, longer carrier lifetimes, longer carrier diffusion distances, and outstanding stability, thus having the potential to show superior performances in optoelectronic devices. In addition, single crystal nanostructures are ideal model systems for studying the fundamental optoelectronic properties of newly designed functional materials. This review provides a thorough introduction to the fundamental theories behind crystal nucleation and growth. In addition, we provide an in-depth analysis of the application of classic ideas to the experimental formation of perovskite crystals including inorganic and hybrid halide perovskites with low-dimensional and three-dimensional structures. Subsequently, we correlate the crystal structure and optoelectronic properties and summarize the recent advances in the application of perovskite single crystals in various optoelectronic devices. Finally, we discuss the ongoing challenges in single crystal growth and the emerging optoelectronic applications. This review will serve as a valuable resource for future studies on the synthesis and uses of perovskite single crystals

NFC Secure Payment and Verification Scheme with CS E-Ticket

As one of the most important techniques in IoT, NFC (Near Field Communication) is more interesting than ever. NFC is a short-range, high-frequency communication technology well suited for electronic tickets, micropayment, and access control function, which is widely used in the financial industry, traffic transport, road ban control, and other fields. However, NFC is becoming increasingly popular in the relevant field, but its secure problems, such as man-in-the-middle-attack and brute force attack, have hindered its further development. To address the security problems and specific application scenarios, we propose a NFC mobile electronic ticket secure payment and verification scheme in the paper. The proposed scheme uses a CS E-Ticket and offline session key generation and distribution technology to prevent major attacks and increase the security of NFC. As a result, the proposed scheme can not only be a good alternative to mobile e-ticket system but also be used in many NFC fields. Furthermore, compared with other existing schemes, the proposed scheme provides a higher security

A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation

Hadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor microbiosphere. Currently, the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is unknown. Here, analyses of carbon isotope composition in a ~ 750 cm long sediment core from the Challenger Deep revealed noncontinuous deposition, with anomalous 14C ages likely caused by seismically driven mass transport and the funneling effect of trench geomorphology. Microbial community composition and diverse enzyme activities in the upper ~ 27 cm differed from those at lower depths, probably due to sudden sediment deposition and differences in redox condition and organic matter availability. At lower depths, microbial population numbers, and composition remained relatively constant, except at some discrete depths with altered enzyme activity and microbial phyla abundance, possibly due to additional sudden sedimentation events of different magnitude. Evidence is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic populations. Such depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere

Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion

The effects of the glycoprotein IIb/IIIa receptor inhibitor tirofiban in patients with acute ischemic stroke but who have no evidence of complete occlusion of large or medium-sized vessels have not been extensively studied. In a multicenter trial in China, we enrolled patients with ischemic stroke without occlusion of large or medium-sized vessels and with a National Institutes of Health Stroke Scale score of 5 or more and at least one moderately to severely weak limb. Eligible patients had any of four clinical presentations: ineligible for thrombolysis or thrombectomy and within 24 hours after the patient was last known to be well; progression of stroke symptoms 24 to 96 hours after onset; early neurologic deterioration after thrombolysis; or thrombolysis with no improvement at 4 to 24 hours. Patients were assigned to receive intravenous tirofiban (plus oral placebo) or oral aspirin (100 mg per day, plus intravenous placebo) for 2 days; all patients then received oral aspirin until day 90. The primary efficacy end point was an excellent outcome, defined as a score of 0 or 1 on the modified Rankin scale (range, 0 [no symptoms] to 6 [death]) at 90 days. Secondary end points included functional independence at 90 days and a quality-of-life score. The primary safety end points were death and symptomatic intracranial hemorrhage. A total of 606 patients were assigned to the tirofiban group and 571 to the aspirin group. Most patients had small infarctions that were presumed to be atherosclerotic. The percentage of patients with a score of 0 or 1 on the modified Rankin scale at 90 days was 29.1% with tirofiban and 22.2% with aspirin (adjusted risk ratio, 1.26; 95% confidence interval, 1.04 to 1.53, P = 0.02). Results for secondary end points were generally not consistent with the results of the primary analysis. Mortality was similar in the two groups. The incidence of symptomatic intracranial hemorrhage was 1.0% in the tirofiban group and 0% in the aspirin group. In this trial involving heterogeneous groups of patients with stroke of recent onset or progression of stroke symptoms and nonoccluded large and medium-sized cerebral vessels, intravenous tirofiban was associated with a greater likelihood of an excellent outcome than low-dose aspirin. Incidences of intracranial hemorrhages were low but slightly higher with tirofiban

Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke

Importance It is uncertain whether intravenous methylprednisolone improves outcomes for patients with acute ischemic stroke due to large-vessel occlusion (LVO) undergoing endovascular thrombectomy. Objective To assess the efficacy and adverse events of adjunctive intravenous low-dose methylprednisolone to endovascular thrombectomy for acute ischemic stroke secondary to LVO. Design, Setting, and Participants This investigator-initiated, randomized, double-blind, placebo-controlled trial was implemented at 82 hospitals in China, enrolling 1680 patients with stroke and proximal intracranial LVO presenting within 24 hours of time last known to be well. Recruitment took place between February 9, 2022, and June 30, 2023, with a final follow-up on September 30, 2023.InterventionsEligible patients were randomly assigned to intravenous methylprednisolone (n = 839) at 2 mg/kg/d or placebo (n = 841) for 3 days adjunctive to endovascular thrombectomy. Main Outcomes and Measures The primary efficacy outcome was disability level at 90 days as measured by the overall distribution of the modified Rankin Scale scores (range, 0 [no symptoms] to 6 [death]). The primary safety outcomes included mortality at 90 days and the incidence of symptomatic intracranial hemorrhage within 48 hours. Results Among 1680 patients randomized (median age, 69 years; 727 female [43.3%]), 1673 (99.6%) completed the trial. The median 90-day modified Rankin Scale score was 3 (IQR, 1-5) in the methylprednisolone group vs 3 (IQR, 1-6) in the placebo group (adjusted generalized odds ratio for a lower level of disability, 1.10 [95% CI, 0.96-1.25]; P = .17). In the methylprednisolone group, there was a lower mortality rate (23.2% vs 28.5%; adjusted risk ratio, 0.84 [95% CI, 0.71-0.98]; P = .03) and a lower rate of symptomatic intracranial hemorrhage (8.6% vs 11.7%; adjusted risk ratio, 0.74 [95% CI, 0.55-0.99]; P = .04) compared with placebo. Conclusions and Relevance Among patients with acute ischemic stroke due to LVO undergoing endovascular thrombectomy, adjunctive methylprednisolone added to endovascular thrombectomy did not significantly improve the degree of overall disability.Trial RegistrationChiCTR.org.cn Identifier: ChiCTR210005172

Experimental and Theoretical Study on Flexural Behavior of GFRP- and CFRP-Reinforced Concrete Beams after High-Temperature Exposure

In this study, in order to study the flexural behavior of fiber-reinforced polymer (FRP) bars with reinforced concrete beams under static loads after high-temperature exposure, seven pieces of FRP-reinforced concrete beams were subjected to static bending tests and calculation model derivations. Four-point bending tests were carried out on FRP-reinforced concrete beams after high temperature treatment. The effects of high temperature and types of FRP bars on the cracking load, crack development, deflection and ultimate capacity, and failure mode of concrete beams were investigated. The test results show that the maximum crack width, deflection, and ultimate bearing capacity of GFRP- and CFRP-reinforced concrete beams decrease obviously with a rise in high temperature. After the exposure of 400 °C for 2 h, compared with the behavior of concrete beams at room temperature, the maximum crack width of GFRP and CFRP-reinforced concrete beams increased by 42.9% and 41.7%, respectively, the deflection increases by 103.6% and 22.0%, and the ultimate bearing capacity decrease by 11.9% and 3.9%. Meanwhile, through the analysis of the existing research results and test results, the calculation models for the maximum crack width, deflection, and residual ultimate capacity of FRP-reinforced concrete beams after exposure of high temperature were proposed. For FRP-reinforced concrete beams after high-temperature exposure, the errors between the measured maximum crack width, stiffness, residual bearing capacity, and their corresponding calculated values using the model were mostly less than 10%. The calculated value using the proposed model in this research is in good agreement with the measured value. The mechanical properties of FRP-reinforced high-strength concrete structures after high-temperature exposure can be preliminarily predicted, which provides a new theoretical basis for the application of FRP-reinforced concrete structures

The Importance of Subsurface Processes in Land Surface Modeling over a Temperate Region: An Analysis with SMAP, Cosmic Ray Neutron Sensing and Triple Collocation Analysis

Land surface models (LSMs) simulate water and energy cycles at the atmosphere–soil interface, however, the physical processes in the subsurface are typically oversimplified and lateral water movement is neglected. Here, a cross-evaluation of land surface model results (with and without lateral flow processes), the National Aeronautics and Space Administration (NASA) Soil Moisture Active/Passive (SMAP) mission soil moisture product, and cosmic-ray neutron sensor (CRNS) measurements is carried out over a temperate climate region with cropland and forests over western Germany. Besides a traditional land surface model (the Community Land Model (CLM) version 3.5), a coupled land surface-subsurface model (CLM-ParFlow) is applied. Compared to CLM stand-alone simulations, the coupled CLM-ParFlow model considered both vertical and lateral water movement. In addition to standard validation metrics, a triple collocation (TC) analysis has been performed to help understanding the random error variances of different soil moisture datasets. In this study, it is found that the three soil moisture datasets are consistent. The coupled and uncoupled model simulations were evaluated at CRNS sites and the coupled model simulations showed less bias than the CLM-standalone model (−0.02 cm3 cm−3 vs. 0.07 cm3 cm−3), similar random errors, but a slightly smaller correlation with the measurements (0.67 vs. 0.71). The TC-analysis showed that CLM-ParFlow reproduced better soil moisture dynamics than CLM stand alone and with a higher signal-to-noise ratio. This suggests that the representation of subsurface physics is of major importance in land surface modeling and that coupled land surface-subsurface modeling is of high interes