2,2,4,4-Tetra­phenyl-1,3-bis­(3,3,5,5-tetra­methyl-1,1-diphenyl-5-vinyl­trisilox­an-1-yl)­cyclo­disilazane

The title mol­ecule, C60H70N2O4Si8, lies on an inversion center. In the asymmetric unit, one of the phenyl rings is disordered over two sets of sites with refined occupancies 0.58 (2) and 0.42 (2). In addition, in two substitution sites of the terminal dimeth­yl(vin­yl)silyl unit, a methyl group and the vinyl group are disordered over the same site with refined occupancies 0.523 (13) and 0.477 (13)

Cyclic performance evaluation of a polyethylenimine/silica adsorbent with steam regeneration using simulated NGCC flue gas and actual flue gas of a gas-fired boiler in a bubbling fluidized bed reactor

To accelerate the deployment of Carbon Capture and Storage (CCS) based on the solid amine adsorbents towards a practical scale application relevant to Natural Gas Combined Cycle (NGCC) power plants, this study has evaluated the cyclic performance of a polyethylenimine/silica adsorbent of kg scale in a laboratory scale bubbling fluidized bed reactor. A high volumetric concentration 80?90 vol% of steam mixed with N2 and CO2 has been used as the stripping gas during a typical temperature swing adsorption (TSA) cycle. Both the simulated NGCC flue gas and the actual flue gas from a domestic gas boiler have been used as the feed gas of the CO2 capture tests with the solid adsorbent. Various characterization has been carried out to elucidate the possible reasons for the initial capacity decline under the steam regeneration conditions. The effect of presence of CO2 in the stripping gas has also been studied by comparing the working capacities using different regeneration strategies. It has been demonstrated that the breakthrough and equilibrium CO2 adsorption capacities can be stabilized at approximately 5.9 wt% and 8.6 wt%, respectively, using steam regeneration for both the simulated and actual natural gas boiler flue gases. However, using a concentration of 15 vol% CO2 in the stripping gas has resulted in a significantly low working capacity at a level of 1.5 wt%, most likely due to the incomplete C

Herb Target Prediction Based on Representation Learning of Symptom related Heterogeneous Network.

Traditional Chinese Medicine (TCM) has received increasing attention as a complementary approach or alternative to modern medicine. However, experimental methods for identifying novel targets of TCM herbs heavily relied on the current available herb-compound-target relationships. In this work, we present an Herb-Target Interaction Network (HTINet) approach, a novel network integration pipeline for herb-target prediction mainly relying on the symptom related associations. HTINet focuses on capturing the low-dimensional feature vectors for both herbs and proteins by network embedding, which incorporate the topological properties of nodes across multi-layered heterogeneous network, and then performs supervised learning based on these low-dimensional feature representations. HTINet obtains performance improvement over a well-established random walk based herb-target prediction method. Furthermore, we have manually validated several predicted herb-target interactions from independent literatures. These results indicate that HTINet can be used to integrate heterogeneous information to predict novel herb-target interactions

More expressions of BDNF and TrkB in multiple hepatocellular carcinoma and anti-BDNF or K252a induced apoptosis, supressed invasion of HepG2 and HCCLM3 cells

<p>Abstract</p> <p>Background</p> <p>Brain-derived neurotrophic factor (BDNF) and its receptor Tropomysin-related kinase B (TrkB) are commonly up-regulated in a variety of human tumors. However, the roles of BDNF/TrkB in hepatocellular carcinoma (HCC) have been poorly investigated.</p> <p>Methods</p> <p>We evaluated the expressions of BDNF and TrkB in 65 cases of HCC by immunohistochemical staining. Moreover, in human HCC cell lines of HepG2 and high metastatic HCCLM3, the secretory BDNF in supernatant was measured by ELISA, the effects of BDNF neutralizing antibody or Trk tyrosine kinase inhibitor K252a on apoptosis and invasion were examined by flow cytometry and transwell assay respectively.</p> <p>Results</p> <p>Higher expression of BDNF (63.1%) or positive expression of TrkB (55.4%) was found in HCC specimens, which was significantly correlated with multiple and advanced stage of HCC. BDNF secretory level in HCCLM3 was higher than that in HepG2 cells. Both anti-BDNF and K252a effectively induced apoptosis and suppressed invasion of HepG2 and HCCLM3 cells.</p> <p>Conclusions</p> <p>These findings suggested that BDNF/TrkB are essential for HCC cells survival and invasion. BDNF/TrkB signaling should probably be an effective target to prevent HCC advancement.</p

Toxicity study of Gloydius brevicaudus venom on Hela and Hep G2 cells

The purpose of this study was to explore the cytotoxicity of Gloydius brevicauda venom on tumor cells. Hela and Hep G2 cells were used as the research subjects. The MTT assay was employed to investigate the proliferative activity of snake venom on tumor cells. The cell scratch assay was conducted to study the migration ability of tumor cells treated with snake venom. The Hoechst 33258 fluorescent staining method was utilized to examine the damage caused by snake venom on tumor cells. The results demonstrated that the half maximal inhibitory concentration (IC50) of the venom on Hela and Hep G2 cells at 48 hours was 8.176 µg/ml and 12.276 µg/ml, respectively. Furthermore, at a concentration of 4 µg/ml, the venom was able to inhibit the migration of tumor cells. Cell nuclear fluorescence staining revealed that the venom at concentrations of 8 µg/ml and 12 µg/ml induced DNA condensation in Hela and Hep G2 cells, respectively. In conclusion, the venom of Gloydius brevicauda was found to inhibit cell proliferation and migration, as well as induce cell apoptosis

Interface magnetic and electrical properties of CoFeB /InAs heterostructures

Amorphous magnetic CoFeB ultrathin films have been synthesized on the narrow band gap semiconductor InAs(100) surface, and the nature of the interface magnetic anisotropy and electrical contact has been studied. Angle-dependent hysteresis loops reveal that the films have an in-plane uniaxial magnetic anisotropy (UMA) with the easy axis along the InAs [0-11] crystal direction. The UMA was found to be dependent on the annealing temperatures of the substrates, which indicates the significant role of the Fe, Co-As bonding at the interface related to the surface condition of the InAs(100). I-V measurements show an ohmic contact interface between the CoFeB films and the InAs substrates, which is not affected by the surface condition of the InAs (100)

Transient enhancement of magnetization damping in CoFeB film via pulsed laser excitation

Laser-induced spin dynamics of in-plane magnetized CoFeB films has been studied by using time-resolved magneto-optical Kerr effect measurements. While the effective demagnetization field shows little dependence on the pump laser fluence, the intrinsic damping constant has been found to be increased from 0.008 to 0.076 with the increase in the pump fluence from 2 mJ/cm2 to 20 mJ/cm2. This sharp enhancement has been shown to be transient and ascribed to the heating effect induced by the pump laser excitation, as the damping constant is almost unchanged when the pump-probe measurements are performed at a fixed pump fluence of 5 mJ/cm2 after irradiation by high power pump pulses