On the KR and WKR points of Orlicz spaces

IIn this paper, we obtain criteria for KR and WKR points in Orlicz function spaces equipped with the Luxemburg norm

Bi-Integrable and Tri-Integrable Couplings of a Soliton Hierarchy Associated with S

Based on the three-dimensional real special orthogonal Lie algebra SO(3), by zero curvature equation, we present bi-integrable and tri-integrable couplings associated with SO(3) for a hierarchy from the enlarged matrix spectral problems and the enlarged zero curvature equations. Moreover, Hamiltonian structures of the obtained bi-integrable and tri-integrable couplings are constructed by applying the variational identities

Offloading in Software Defined Network at Edge with Information Asymmetry: A Contract Theoretical Approach

The proliferation of highly capable mobile devices such as smartphones and tablets has significantly increased the demand for wireless access. Software defined network (SDN) at edge is viewed as one promising technology to simplify the traffic offloading process for current wireless networks. In this paper, we investigate the incentive problem in SDN-at-edge of how to motivate a third party access points (APs) such as WiFi and smallcells to offload traffic for the central base stations (BSs). The APs will only admit the traffic from the BS under the precondition that their own traffic demand is satisfied. Under the information asymmetry that the APs know more about own traffic demands, the BS needs to distribute the payment in accordance with the APs' idle capacity to maintain a compatible incentive. First, we apply a contract-theoretic approach to model and analyze the service trading between the BS and APs. Furthermore, other two incentive mechanisms: optimal discrimination contract and linear pricing contract are introduced to serve as the comparisons of the anti adverse selection contract. Finally, the simulation results show that the contract can effectively incentivize APs' participation and offload the cellular network traffic. Furthermore, the anti adverse selection contract achieves the optimal outcome under the information asymmetry scenario.Comment: 10 pages, 9 figure

Quantitative Study on Walking Space Around Residential Rail Transit Stations in Beijing

Firstly, the key factors affecting the convenience and comfort of walking around Beijing residential rail transit stations were confirmed through questionnaire, the most significant factors respectively are the degree of walking detours and the street ground-floor commercial facilities, then quantitative researches were carried out on the two factors. 13 residential stations in Beijing were selected, and the coefficients of detours both under current situation and the scenario of open communities were calculated, moreover, the current situation was compared with other domestic and foreign cities. The distribution of street ground-floor commercial facilities around 13 stations was investigated, and the Huilongguan station was analyzed in details. The result shows that the degree of walking detours around residential stations in Beijing was relatively serious, and significant factors are, for instance, closed communities and road network. There are relatively continuous underlying commercial facilities over half of the sites, and the facilities around a few of stations were insufficient, the density of street ground-floor commercial facilities within 500 meters of Huilongguan station was 2.42 per 100 meters, which is far less than the walkable standard

Traditional Chinese Medicines in Treatment of Patients with Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) occurs in 95% of the diabetic populations. Management of T2DM is a challenge. Traditional Chinese medicines (TCM) are usually served as adjuvants used to improve diabetic syndromes in combination of routine antidiabetic drugs. For single-herb prescriptions, Ginseng, Bitter melon, Golden Thread, Fenugreek, Garlic, and Cinnamon might have antidiabetic effects in T2DM patients. Among 30 antidiabetic formulas approved by the State Food and Drugs Administrator of China, top 10 of the most frequently prescribed herbs are Membranous Milkvetch Root, Rehmannia Root, Mongolian Snakegourd Root, Ginseng, Chinese Magnoliavine Fruit, Kudzuvine Root, Dwarf Lilyturf Tuber, Common Anemarrhena Rhizome, Barbary Wolfberry Fruit, and India Bread, which mainly guided by the theory of TCM. Their action mechanisms are related to improve insulin sensitivity, stimulate insulin secretion, protect pancreatic islets, and even inhibit intake of intestinal carbohydrates. However, it is very difficult to determine antihyperglycemic components of TCM. Nevertheless, TCM are becoming popular complementary and alternative medicine in treatment of syndromes of T2DM. In the future, it requires further validation of phytochemical, pharmacological, and clinical natures of TCM in T2DM in the future studies, especially for those herbs with a high prescription frequency

Study on the Modified triphenyl tetrazolium chloride – dehydrogenase activity (TTC-DHA) Method in Determination of bioactivity in the up-flow aerated bio-activated carbon filter

The study applied triphenyl tetrazolium chloride-dehydrogenase activity (TTC-DHA) method to detect the activities of attached biofilm on bio-activated carbon (BAC) samples in the up-flow aerated biological activated carbon filter (UABACF) treating textile secondary effluent. Modification to the conventional TTC-DHA determination method was proposed. In the modification, BAC samples were used directly to measure TTC-DHA without pre-separating the attached biofilm from carbon samples. After modification, the mean values of biofilm TTC-DHA activities for the BAC samples at different heights of the biofilter were 25 to 193 times higher than those measured in conventional way. In addition, the microbial activity distribution related more closely to substrate removal along the height of the reactor after modification. The results indicated that high activity of the bacteria that are firmly fixed on the porous surface of the media would be ignored during pre-separation of the attached biofilm from media surface. The study also indicated the influence of granular activated carbon (GAC) adsorption on the bio-activity of attached biofilm. GAC adsorption was favorable in the improvement of the activities within the biofilter, especially when the attached films were destroyed. The modification of TTC-DHA determination method made this technique more convenient and accurate in activity measurement of biofilm fixed on porous surface structured activated carbon.Keywords: Up-flow, aerated bio-filter, BAC, TTC-DHA, bioactivit

Treatment-emergent neuroendocrine prostate cancer: A clinicopathological and immunohistochemical analysis of 94 cases

Purpose: This study aimed to evaluate the pathological characteristics, immunophenotype, and prognosis of treatment-emergent neuroendocrine prostate cancer (T-NEPC). Materials and Methods: We collected 231 repeated biopsy specimens of castration-resistant prostate cancer (CRPC) cases between 2008 and 2019. We used histopathological and immunohistochemical evaluations of Synaptophysin (SYN), ChromograninA (CgA), CD56, androgen receptor (AR), and prostate Results: Among the 231 CRPC cases, 94 (40.7%) cases were T-NEPC. T-NEPC were more likely to present with negative immunohistochemistry for AR (30.9%) and PSA (47.9%) than that of CRPC (8.8% and 17.5%, respectively). Kaplan-Meier analysis revealed that patients with T-NEPC (median overall survival [OS]: 17.6 months, 95% CI: 15.3-19.9 months) had significantly worse survival compared with usual CRPC patients (median OS: 23.6 months, 95% CI: 21.3-25.9 months, log-rank Conclusion: T-NEPC was associated with an unfavorable prognosis, negative immunohistochemistry for PSA in T-NEPC and serum PSA level ≤ 4 ng/ml had a worse prognosis. Urologists and pathologists should recognize the importance of the second biopsy in CRPC to avoid unnecessary diagnosis and treatment delays

Scorpion in Combination with Gypsum: Novel Antidiabetic Activities in Streptozotocin-Induced Diabetic Mice by Up-Regulating Pancreatic PPARγ and PDX-1 Expressions

The management of diabetes without any side effects remains a challenge in medicine. In this study, antidiabetic activity and the mechanism of action of scorpion combined with gypsum (SG) were investigated. Streptozotocin-induced diabetic mice were orally administrated with scorpion (200 mg kg−1 per day) in combination with gypsum (200 mg kg−1 per day) for 5 weeks. SG treatment resulted in decreased body weight, blood glucose and lipid levels, and increased serum and pancreatic insulin levels in diabetic mice. Furthermore, SG significantly increased the number and volume of beta cells in the Islets of Langerhans and promoted peroxisome proliferator-activated receptor gamma and pancreatic duodenal homeobox 1 expressions in pancreatic tissues. However, scorpion or gypsum alone had no significant effect in this animal model. Metformin showed a slight or moderate effect in this diabetic model, but this effect was weak compared with that of SG. Taken together, SG showed a new antidiabetic effect in streptozotocin-induced diabetic mice. This effect may possibly be involved in enhancing beta-cell regeneration and promoting insulin secretion by targeting PPARγ and PDX-1. Moreover, this new effect of SG offers a promising step toward the treatment of diabetic patients with beta-cell failure as a complementary and alternative medicine