Acarbose: A New Option in the Treatment of Ulcerative Colitis by Increasing Hydrogen Production

Acarbose，which is clinically widely used to treat Type 2 Diabetes，is thought to act at the small intestine by competitively inhibiting enzymes that delay the release of glucose from complex carbohydrates, thereby specifically reducing post prandial glucose excursion. The major side-effect of treatment with acarbose, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in considerable amount of hydrogen. We propose that enteric benefits of acarbose is partly attributable to be their ability to neutralise oxidative stress via increased production of H2 in the gastrointestinal tract. Therefore, symptoms of ulcerative colitis in human beings can be ameliorated by acarbose

HUBBLE SPACE TELESCOPE OBSERVATIONS AND GEOMETRIC MODELS OF COMPACT MULTIPOLAR PLANETARY NEBULAE

published_or_final_versio

Improved bounds on the L(2,1)-number of direct and strong products of graphs

2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Molecular Line Observations of the Carbon-rich Circumstellar Envelope CIT 6 at 7 mm Wavelengths

published_or_final_versio

Modeling and identification of gene regulatory networks: A Granger causality approach

It is of increasing interest in systems biology to discover gene regulatory networks (GRNs) from time-series genomic data, i.e., to explore the interactions among a large number of genes and gene products over time. Currently, one common approach is based on Granger causality, which models the time-series genomic data as a vector autoregressive (VAR) process and estimates the GRNs from the VAR coefficient matrix. The main challenge for identification of VAR models is the high dimensionality of genes and limited number of time points, which results in statistically inefficient solution and high computational complexity. Therefore, fast and efficient variable selection techniques are highly desirable. In this paper, an introductory review of identification methods and variable selection techniques for VAR models in learning the GRNs will be presented. Furthermore, a dynamic VAR (DVAR) model, which accounts for dynamic GRNs changing with time during the experimental cycle, and its identification methods are introduced. © 2010 IEEE.published_or_final_versionThe 9th International Conference on Machine Learning and Cybernetics (ICMLC 2010), Qingdao, China, 11-14 July 2010. In Proceedings of the 9th ICMLC, 2010, v. 6, p. 3073-307

[Fe iii] lines in the planetary nebula NGC 2392

The Eskimo Nebula (NGC 2392) is a young double-shell planetary nebula (PN). Its intrinsic structure and the responsible shaping mechanism are still not fully understood. We present new optical spectroscopy of NGC 2392 at two different locations to obtain the spectra of the inner and outer shells. Several [Fe iii] lines are clearly detected. We find that these [Fe iii] lines mostly originate from the inner shell. Therefore, we suggest that NGC 2392 might have an intrinsic structure similar to the Ant Nebula Mz 3, which exhibits a number of [Fe iii] lines from the central dense regions. In this scenario, the inner and outer shells correspond to the central emission core and the outer lobes of Mz 3, respectively. © 2012 International Astronomical Union.published_or_final_versio

T-DNA integration patterns in transgenic maize lines mediated by Agrobacterium tumefaciens

To explore transfer deoxyribonucleic acid (T-DNA) integration patterns in the maize genome, we improved the protocol of thermal asymmetric interlaced polymerase chain reaction (TAIL-PCR), and amplified the flanking sequences around T-DNA integration sites from 70 independent transgenic maize lines mediated by Agrobacterium tumefaciens. Out of 64 specific amplified fragments, 32 and 9 are homologous to the sequences of the maize genome and the expression plasmid, respectively. For 26 of them, a filler sequence was found flanking the cleavage sites. These results demonstrate that cleavage occurs not only during the T-DNA borders but also inside or outside the borders. The border sequences and some inside sequences can be deleted, and filler sequences can be inserted. Illegitimate recombination is a major pattern of T-DNA integration, while some hot spots and preference are present on maize chromosomes.Key words: Agrobacterium tumefaciens, maize, thermal asymmetric interlaced PCR, transfer DNA,transgenics

Comprehensive scheme for subpixel variable block-size motion estimation

2010-2011 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe