Green Vehicle Routing Optimization Based on Carbon Emission and Multiobjective Hybrid Quantum Immune Algorithm

© 2018 Xiao-Hong Liu et al. Green Vehicle Routing Optimization Problem (GVROP) is currently a scientific research problem that takes into account the environmental impact and resource efficiency. Therefore, the optimal allocation of resources and the carbon emission in GVROP are becoming more and more important. In order to improve the delivery efficiency and reduce the cost of distribution requirements through intelligent optimization method, a novel multiobjective hybrid quantum immune algorithm based on cloud model (C-HQIA) is put forward. Simultaneously, the computational results have proved that the C-HQIA is an efficient algorithm for the GVROP. We also found that the parameter optimization of the C-HQIA is related to the types of artificial intelligence algorithms. Consequently, the GVROP and the C-HQIA have important theoretical and practical significance

Long Non-Coding RNAs Dysregulation and Function in Glioblastoma Stem Cells

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Experimental observation of chiral phonons in monolayer WSe2

Chirality characterizes an object that is not identical to its mirror image. In condensed matter physics, Fermions have been demonstrated to obtain chirality through structural and time-reversal symmetry breaking. These systems display unconventional electronic transport phenomena such as the quantum Hall effect and Weyl semimetals. However, for bosonic collective excitations in atomic lattices, chirality was only theoretically predicted and has never been observed. We experimentally show that phonons can exhibit intrinsic chirality in monolayer tungsten diselenide, whose lattice breaks the inversion symmetry and enables inequivalent electronic K and -K valley states. The time-reversal symmetry is also broken when we selectively excite the valley polarized holes by circularly polarized light. Brillouin-zone-boundary phonons are then optically created by the indirect infrared absorption through the hole-phonon interactions. The unidirectional intervalley transfer of holes ensures that only the phonon modes in one valley are excited. We found that such photons are chiral through the transient infrared circular dichroism, which proves the valley phonons responsible to the indirect absorption has non-zero pseudo-angular momentum. From the spectrum we further deduce the energy transferred to the phonons that agrees with both the first principle calculation and the double-resonance Raman spectroscopy. The chiral phonons have significant implications for electron-phonon coupling in solids, lattice-driven topological states, and energy efficient information processing

Deterministic Polynomial-Time Algorithms for Designing Short DNA Words

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Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm

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Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib.

Signaling via the B cell receptor (BCR) plays an important role in the pathogenesis and progression of chronic lymphocytic leukemia (CLL). This is underscored by the clinical effectiveness of ibrutinib, an inhibitor of Bruton's tyrosine kinase (BTK) that can block BCR-signaling. However, ibrutinib cannot induce complete responses (CR) or durable remissions without continued therapy, suggesting alternative pathways also contribute to CLL growth/survival that are independent of BCR-signaling. ROR1 is a receptor for Wnt5a, which can promote activation of Rac1 to enhance CLL-cell proliferation and survival. In this study, we found that CLL cells of patients treated with ibrutinib had activated Rac1. Moreover, Wnt5a could induce Rac1 activation and enhance proliferation of CLL cells treated with ibrutinib at concentrations that were effective in completely inhibiting BTK and BCR-signaling. Wnt5a-induced Rac1 activation could be blocked by cirmtuzumab (UC-961), an anti-ROR1 mAb. We found that treatment with cirmtuzumab and ibrutinib was significantly more effective than treatment with either agent alone in clearing leukemia cells in vivo. This study indicates that cirmtuzumab may enhance the activity of ibrutinib in the treatment of patients with CLL or other ROR1+ B-cell malignancies

The effect of cationic surfactants on improving natural clinoptilolite for the flotation of cesium

Flotation using cationic surfactants has been investigated as a rapid separation technique to dewater clinoptilolite ion exchange resins, for the decontamination of radioactive cesium ions (Cs+) from nuclear waste effluent. Initial kinetic and equilibrium adsorption studies of cesium, suggested the large surface area to volume ratio of the fine zeolite contributed to fast adsorption kinetics and high capacities (qc = 158.3 mg/g). Adsorption of ethylhexadecyldimethylammonium bromide (EHDa-Br) and cetylpyridinium chloride (CPC) surfactant collectors onto both clean and 5 ppm Cs+ contaminated clinoptilolite was then measured, where distribution coefficients (Kd) as high as 10,000 mL/g were evident with moderate concentrations CPC. Measurements of particle sizes confirmed that adsorption of surfactant monolayers did not lead to significant aggregation of the clinoptilolite, while 4, highlighting the great viability of flotation to separate and concentrate the contaminated powder in the froth phase

The effect of pre-activation and milling on improving natural clinoptilolite for ion exchange of cesium and strontium

Natural clinoptilolite, of relatively low-grade, was investigated for its capability to remove cesium and strontium ions from water and simulated seawater. To improve its capacity, the material was pre-activated with concentrated NaCl and HCl solutions. Additionally, it was milled to a number of < 300 μm size fractions, to expose exchange sites. Electron microscopy was used to characterise the naturally occurring impurities, where regions of high iron and potassium content was shown to correlate to lower levels of cesium adsorption. Adsorption kinetics for natural and activated resins with 5, 300 and 1500 ppm salt solutions were fitted with the Pseudo-Second Order (PSO) rate model. Activation led to clear increases in initial adsorption rate for both Cs+ and Sr2+, but only enhanced the overall rate constant for Cs+, due to the weaker interaction of the Sr2+. Equilibrium isotherms were compared with Langmuir and Freundlich monolayer models, where the adsorption capacity (Qc) for Cs+ was 67 mg/g which increased by over 100% with NaCl activation to 140 mg/g. Values for Sr2+ were significantly lower at 35 mg/g, with a considerably smaller enhancement with activation to 52 mg/g. Milling of the natural clinoptilolite was found to increase Cs+ uptake to similar levels as activation, in a linear correlation with specific surface area; although, improvements for Sr2+ were again lower, due to its weaker interaction with surface sites. In simulated seawater solutions, all materials gave considerably reduced performance due to K+ ion competition, with Sr2+ uptake decreased more extensively compared to Cs+. Overall, this work highlights that pre-activation and milling of clinoptilolite can be used to significantly enhance the grade of the ore for nuclear effluent treatment in low-salinity conditions