The many-faced KSR1: a tumor suppressor in breast cancer

Emerging evidence supports the dual function of kinase suppressor of Ras 1 (KSR1) as an active kinase and a scaffold, although it has been extensively referred as a pseudokinase, due to the absence of key residues in its catalytic domain [1, 2]. As a scaffolding protein, KSR1 orchestrates the assembly of the protein kinases RAF, mitogen activated protein kinase (MAPK) kinase (MEK), and extracellular signal-regulated kinase (ERK) in the canonical Ras-RAF-MAPKs pathway, in a Ras-dependent manner or upon growth factor treatment [1, 3]. Conversely, structural and biochemical studies reveal that KSR1 is capable of phosphorylating MEK and more importantly, the catalytic activity of KSR is markedly increased when BRAF or inhibitor-bound CRAF is introduced in the complexes [1, 4, 5]. Such findings add complexity to th

Development Strategy, Optimal Industrial Structure and Economic Growth in Less Developed Countries

In this paper, we develop an endogenous growth model that combines structural change with repeated product improvements. There are two sectors in the present paper, one is traditional sector, and the other is modern sector. The technological progress in the traditional sector takes the form of horizontal innovation based on expanding variety, while the technologies in the modern sector become not only increasingly capital-intensive but also progressively productive over time. The application of the basic model to the less developed economies show that the optimal industrial structure in the less developed countries (LDCs) is endogenously determined by its factor endowments; the firm in the LDCs that enters the capital-intensive, advanced industry in the developed countries (DCs) would be nonviable owing to the relative scarcity of capital in the LDCs factor endowments; whether the industrial structure matches with the factor endowment structure or not is the fundamental cause to explain differences in economic performance among the LDCs.Capital Intensity, Development Strategy, Factor Endowments, Endogenous Growth, Industrial Structure, productivity, technology, Viability

Industrial structure, appropriate technology and economic growth in less developed countries

The authors develop an endogenous growth model that combines structural change with repeated product improvement. That is, the technologies in one sector of the model become not only increasingly capital-intensive, but also progressively productive over time. Application of the basic model to less developed economies shows that the (optimal) industrial structure and the (most) appropriate technologies in less developed economies are endogenously determined by their factor endowments. A firm in a less developed country that enters a capital-intensive, advanced industry in a developed country would be nonviable owing to the relative scarcity of capital in the factor endowments of less developed countries.Economic Theory&Research,Political Economy,Technology Industry,Economic Growth,Inequality

Contextual Attention for Hand Detection in the Wild

We present Hand-CNN, a novel convolutional network architecture for detecting hand masks and predicting hand orientations in unconstrained images. Hand-CNN extends MaskRCNN with a novel attention mechanism to incorporate contextual cues in the detection process. This attention mechanism can be implemented as an efficient network module that captures non-local dependencies between features. This network module can be inserted at different stages of an object detection network, and the entire detector can be trained end-to-end. We also introduce large-scale annotated hand datasets containing hands in unconstrained images for training and evaluation. We show that Hand-CNN outperforms existing methods on the newly collected datasets and the publicly available PASCAL VOC human layout dataset. Data and code: https://www3.cs.stonybrook.edu/~cvl/projects/hand_det_attention

Contextual Attention for Hand Detection in the Wild

We present Hand-CNN, a novel convolutional network architecture for detecting hand masks and predicting hand orientations in unconstrained images. Hand-CNN extends MaskRCNN with a novel attention mechanism to incorporate contextual cues in the detection process. This attention mechanism can be implemented as an efficient network module that captures non-local dependencies between features. This network module can be inserted at different stages of an object detection network, and the entire detector can be trained end-to-end. We also introduce a large-scale annotated hand dataset containing hands in unconstrained images for training and evaluation. We show that Hand-CNN outperforms existing methods on several datasets, including our hand detection benchmark and the publicly available PASCAL VOC human layout challenge. We also conduct ablation studies on hand detection to show the effectiveness of the proposed contextual attention module.Comment: 9 pages, 9 figure

Optical Access Engine Setup and Validation

The optical access engine integrated with the diagnostic and optical measurement techniques is a great platform for engine research because it provides clear visual access to the combustion chamber inside the engines. An optical access engine customized based on a 4-cylinder spark ignited direct injection (SIDI) production engine is located in the Advanced Power Systems Laboratories (APS LABS) at Michigan Technological University. This optical access engine inside the test cell has been set up for different engine research. In this report, two SAE papers in engine research utilizing the optical access engine are reviewed to gain basic understanding of the methodology. Though the optical engine in APS LABS is a little bit different from the engines used in the literature, the methodology in the papers provides guidelines for engine research through optical access engines. In addition, the optical access engine instrumentation including the test cell setup and the optical engine setup is described in detail in the report providing a solid record for later troubleshooting and reference. Finally, the motoring tests, firing tests and optical imaging experiment on the optical engine have been performed to validate the instrumentation. This report only describes so far the instrumentation of the optical engine in the APS LABS by April 2015

Development Strategy, Viability, and Economic Institutions: The Case of China

development strategy, institution, viability, trinity system

THE PROBLEM OF TAXING FARMERS IN CHINA

Replaced with revised version of paper 08/25/03.Agricultural Finance, H22, O53,