Supporting multiple output devices on an ad-hoc basis in visualisation

In recent years, new visualisation techniques and devices, such as remote visualisation and stereoscopic displays, have been developed to help researchers. In a remote visualisation environment the user may want to see visualisation on a different device, such as a PDA or stereo device, and in different circumstances. Each device needs to be configured correctly, otherwise it may lead to an incorrect rendering of the output. For end users, however, it can be difficult to configure each device without a knowledge of the device property and rendering. Therefore, in a multiple user and multiple display environment, to obtain the correct display for each device can be a challenge. In this project, the focus on investigating a solution that can support end users to use different display devices easily. The proposed solution is to develop an application that can support the ad-hoc use of any display device without the system being preconfigured in advance. Thus, end users can obtain the correct visualisation output without any complex rendering configuration. We develop a client-server based approach to this problem. The client application can detect the properties of a device and the server application can use these properties to configure the rendering software to generate the correct image for subsequent display on the device. The approach has been evaluated through many tests and the results show that using the application is a useful in helping end users use different display devices in visualisation

Comprehensive evaluation of heat resistance in 68 Vitis germplasm resources

Temperature is a crucial factor limiting plant growth. Grapevine is frequently subjected to high temperature during its maturation stage, and this seriously influences grape growth and development. Here, we selected 68 grapevine varieties and examined the heat damage index, relative electrolyte leakage, and Fv/Fm after exposure to 50 °C. 'Red Seedless', 'Hong Yuli', 'At Suma', 'Hupei 3#', and 'Tamina' were tolerant to high-temperature stress; however, 'Brazil', 'Shenfeng', 'Gold Finger', 'Heimeixiang', 'Kaiji', and 'Zuijinxiang' varieties were sensitive to high-temperature stress and died after exposure to 50 °C. Our findings provide a valuable insight into resistance breeding programs for grapevine

Bagging Affecting Sugar and Anthocyanin Metabolism in the Ripening Period of Grape Berries

Grapevine is one of the most important fruit-bearing plants worldwide, for which bagging treatments can effectively improve fruit quality. However, the low-light conditions caused by bagging can delay grape berry maturation. Here, we analyzed glucose, fructose, and anthocyanin contents and the expression of sugar and anthocyanin-metabolism pathway genes in the grape berries of two cultivars, ‘Shenhua’ and ‘Shenfeng’, under different bagging treatments. Color development was incomplete in bagged grape berries and their soluble sugar contents were lower than those detected in un-bagged fruits. However, fruit color and SSC could be rapidly restored to normal levels after removing bags. Light affects the accumulation of sugar in grape berries, especially near the maturation period, as well as the contents and compositions of anthocyanins in the skin of grape berries. Although light helps in the accumulation of anthocyanins, significant differences were detected in anthocyanin composition between the two grapevine varieties. In addition, the expressions of myofibroblastic regulatory genes in the anthocyanin pathway were affected by light, and the light-responsive elements elongated hypocotyl 5 and constitutive photomorphogenic 1 acted synergistically to control grape berry coloration. Overall, these results provide a theoretical basis for the maturation mechanism in grape berries

Diaqua­bis[2-(4-bromo­phen­yl)acetato]bis­(N 4,N 4-dimethyl­pyridin-4-amine)copper(II)

In the title compound, [Cu(C8H6BrO2)2(C7H10N2)2(H2O)2], the CuII atom (site symmetry ) adopts a Jahn–Teller-distorted trans-CuN2O4 octa­hedral coordination, with the aqua O atoms in axially extended sites. An intra­molecular O—H⋯O hydrogen bond helps to establish the conformation and an inter­molecular O—H⋯O hydrogen bond is seen in the crystal packing

Inhibition of cell growth and invasion by epidermal growth factor-targeted phagemid particles carrying siRNA against focal adhesion kinase in the presence of hydroxycamptothecin

<p>Abstract</p> <p>Background</p> <p>Previous studies demonstrated the EGF-targeted phagemid particles carrying siRNA against Akt could be expressed efficiently in the presence of hydroxycamptothecin (HCPT). However, no significant cell growth inhibition was obtained. This study was to further investigate whether the EGF-targeted phagemid particles carrying siRNA would be a promising tool for anti-cancer siRNA delivery.</p> <p>Results</p> <p>We found that pSi4.1-siFAK phagemid particles could significantly inhibit the expression of focal adhesion kinase in the HCPT-treated cells. Moreover, we also observed that the particles could potently suppress cell growth and cell invasion.</p> <p>Conclusion</p> <p>These results indicated that EGF-targeted phagemid particles might be a promising tool for anti-cancer siRNA delivery in the presence of HCPT.</p

Modelling the Effects of Climatic Factors on the Biomass and Rodent Distribution in a Tibetan Grassland Region in China

To identify the main climatic factors from 2007 to 2009 that influence biomass and rodent distribution, 576 fixed sample plots within 81 million km2 of different climatic grassland in Tibet were monitored. The aboveground biomass, the total burrows, the active burrows, the burrow index, and the rodent density in the plots were measured yearly in October. The monthly precipitation and the average temperatures from April to November were obtained for four successive years (2006-2009). Correlative and modelling analyses between the aboveground biomass, the rodent density, and the climatic factors were performed. The results showed that biomass and rodent density were significantly correlated with the climatic factors. Using ridge regression analyses, models of the biomass and rodent density with respect to the monthly precipitations and average temperatures of the previous year were developed. The raw testing data demonstrated that the models can be used approximately to predict biomass and rodent density

ニホンゴ ト アムド・チベット ゴ ニ オケル シエキ ヒョウゲン ノ イミ ニ ツイテ -ニホンゴ キョウイク ノ シテン カラ -

アムド・チベット人学習者が日本語を話す際に「keu jeug」の代わりに「～させる」を使用してしまうのが一般的である。本稿では、この二つの形態が付く両言語の使役表現を「直接関与型使役表現」、「間接関与型使役表現」、「非関与型」という三つのタイプに分け、それぞれの語用論的な意味をさらに下位分類しながら考察した。その結果、両言語の三つのタイプの使役表現の語用論的な意味のうち、完全に共通しているのは「誘導」と「許可」、「放任」場合のみであり、ほかの場合は次のような違いがあることが明らかになった。 第一に「強制」と「供給」の場合、両言語の語用論的な意味は基本的に共通しているものの、形態的には「keu jeug」は「～させる」に対応すると同時に、「～させられる」と「～させてあげる」にも対応している。第二に「供給」の場合、チベット語では目上を被使役者の位置に据えることができるが、日本語ではできない。第三に「依頼」と「譲歩」の場合、チベット語では「keu jeug」で表現できるが、日本語ではできない。チベット語では「依頼」を表すにも「keu jeug」を使うのに、日本語では「～てもらう」を使うのが一般的である。第四として「責任」と「非難」の場合、日本語では「死ぬ」という動詞が述語になる場合を除いて、「～させる」だけではこの意味を表せないが、チベット語ではほかの動詞が述語となる場合も「keu jeug」の形態だけでこの意味を表すことができる。こうした両言語の違いから分かるのは、チベット語の「keu jeug」の形態が付く使役表現は語用論的な意味から言っても、また述語となる動詞との関係から言っても日本語の「～させる」の形態が付く使役表現よりはるかに広い範囲で使われているということである。This paper the targets Japanese causative sentences containing‘-aseru / -saseru’ and causative sentences in the Tibetan Amdo dialect containing ‘keu jeug’. Three types of causative sentences are classified into‘participated,’‘ exempted’ and ‘mixed’ and their pragmatic meanings are subclassified. The results show that the two languages are consistent in the pragmatic meaning in the expressions of ‘induction’ in the participated type and ‘allowance or release’ in the mixed type; however, the following differences are revealed when other pragmatic meanings are expressed: first, in the expression of ‘forced supply’in the participated type, the ‘Keu jeug’ in Tibetan corresponds to ‘-aserareru / - saseteageru’ in Japanese at the morphological level; second, in the expression of ‘supply’, the causative expressions can not be applied to the requirement placed on elders in Japanese, though there is no such limitation in Tibetan; third, in the expressions of ‘dependence and retreating’ in the mixed type, the causative expressions can be applied in Tibetan, while they cannot be used in Japanese; and forth, in the expressions of‘responsibility or scolding’, there is only ‘Shinu’, which can be used as a predicate in Japanese, while almost every verb can be used as the predicate in causative expressions in Tibetan

Efficacy and safety of bempedoic acid for prevention of cardiovascular events and diabetes: a systematic review and meta-analysis.

BACKGROUND: Bempedoic acid is an oral, once-daily, first-in-class drug being developed for the treatment of hyperlipidemia. However, evidence of bempedoic acid use for the prevention of cardiovascular events and diabetes is lacking. Thus, we aim to evaluate the benefit and safety of bempedoic acid use for the prevention of cardiovascular events and diabetes. METHODS: We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials with no language restriction from inception until March 3, 2020. Pairs of reviewers independently identified randomized controlled trials comparing the use of bempedoic acid with placebo or no treatment for primary prevention of cardiovascular events in statin-intolerant patients with hypercholesterolemia. The primary outcomes were major adverse cardiac events, and percent change in LDL-C. RESULTS: We identified 11 trials including a total of 4391 participants. Bempedoic acid use was associated with a reduction in composite cardiovascular outcome (RR 0.75, 95% CI 0.56-0.99; I CONCLUSIONS: Bempedoic acid in patients with hypercholesterolemia was associated with a lower risk of cardiovascular events and diabetes

Bis(μ-2-phenyl­quinoline-4-carboxyl­ato)bis­[aqua­(1,10-phenanthroline)(2-phenyl­quinoline-4-carboxyl­ato)manganese(II)] dihydrate

In the centrosymmetric dinuclear title complex, [Mn2(C16H10NO2)4(C12H8N2)2(H2O)2]·2H2O, the MnII cation is in a distorted octa­hedral coordination geometry defined by two N atoms from a 1,10-phenanthroline ligand, one water O atom and three O atoms from three 2-phenyl­quinoline-4-carboxyl­ate anions. A pair of 2-phenyl­quinoline-4-carboxyl­ate anions bridge two Mn cations, forming the dinuclear mol­ecule. An intra­moleculr O—H⋯O hydrogen bond occurs. Inter­molecular O—H⋯O and O—H⋯N hydrogen bonds are present in the crystal structure