Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome

Aim: Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients. Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits. Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups. Conclusion: These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS

Iron Deficiency Anaemia is Associated with Decreased Levels of Macrophage Migration Inhibitory Factor and Monocyte Chemoattractant Protein-1

Many bodily systems are affected by iron deficiency anaemia (IDA), including the immune system. However, the pathophysiological mechanisms whereby this anaemia promotes deterioration in immunity remain largely unexplained. In order to enlighten this pathophysiological link, serum levels of macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1), which play an important roles in a healthy functioning immune system, were examined in patients with IDA and healthy volunteers. A total of 30 patients with IDA (mean age 33.6+/-7.8 years, 30% male) and 30 healthy individuals (mean age 30.1 +/- 8.8 years, 27 % male) were included. Serum MIF and MCP-1 levels were measured in a sandwich-assay format, using commercial enzyme-linked immunosorbent assay kits. There was no statistically significant difference in age and gender distribution between participants with IDA and controls (p> 0.05). Serum MIF and MCP-1 concentrations were lower in the IDA group than in the control group (p < 0.005, and p < 0.01, respectively). When considering the role of MIF and MCP-1 in maintaining the normal immune response of the organism, a decrease in production in patients with IDA may contribute to immune dysfunction in these individuals

The Relationship Neutrophil-Lymphocyte Ratio and Heart Rate Recovery

AimIt has been shown that heart rate recovery index is an independent risk factor for cardiovascular mortality. It has been reported in most epidomiologic studies that an elevated neutrophil-lymphocyte ratio is strongly associated with cardiovascular diseases. The aim of this study was to investigate whether there is a relationship between heart rate recovery index and neutrophillymphocyte ratio.Materials and MethodsA total of 238 patients who underwent coronary angiography due to abnormal treadmill exercise test results and who admitted to Cardiology Department of Faculty of Medicine at Namık Kemal University were evaluated retrospectively. heart rate recovery index was accepted as abnormal when the difference between peak heart rate at maximal exercise and the heart rate at the first minute of recovery phase is 18 beat or less.ResultsIn the comparison between those with abnormal heart rate recovery index and those with normal heart rate recovery index in terms of neutrophil count and neutrophil-lymphocyte ratio was found a significant relationship. (respectively, p=0,027 ve p=0.000).ConclusionConsequently, our findings may potentially suggest that an elevated neutrophil-lymphocyte ratio in patients with abnormal heart rate recovery index might be related to cardiovascular mortality and morbidity. The investigation of the prognostic significance of elevated neutrophil-lymphocyte ratio in patients with abnormal heart rate recovery index in future prospective studies will be provide more conclusive evidence

COVID-19 in pediatric nephrology centers in Turkey

Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10–15 years old. Half of the patients were on kidney replacement therapy: kidney transplant (KTx) recipients (n = 56, 27.5%), patients receiving chronic hemodialysis (n = 33, 16.3%) and those on peritoneal dialysis (PD) (n = 18, 8.9%). Fifty-four (26.6%) children were asymptomatic. Eighty-two (40.3%) patients were hospitalized and 23 (28%) needed intensive care unit admission. Fifty-five percent of the patients were not treated, while the remaining was given favipiravir (20.7%), steroid (16.3%), and hydroxychloroquine (11.3%). Acute kidney injury developed in 19.5% of hospitalized patients. Five (2.4%) had MIS-C. Eighty-three percent of the patients were discharged without any apparent sequelae, while 7 (3.4%) died. One hundred and eight health care staff were infected during the study period. Conclusion: COVID-19 was most commonly seen in patients who underwent KTx and received HD. The combined immunosuppressive therapy and frequent exposure to the hospital setting may increase these patients’ susceptibility. Staff infections before vaccination era were alarming, various precautions should be taken for infection control, particularly optimal vaccination coverage

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P &lt; 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Barbarossa Harekâtı'nın Türk basınına yansıması

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2018.This work is a student project of the Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.The History of Turkey course (HIST200) is a requirement for all Bilkent undergraduates. It is designed to encourage students to work in groups on projects concerning any topic of their choice that relates to the history of Turkey. It is designed as an interactive course with an emphasis on research and the objective of investigating events, chronologically short historical periods, as well as historic representations. Students from all departments prepare and present final projects for examination by a committee, with 10 projects chosen to receive awards.Includes bibliographical references (pages 18-19).by Abdürrahim Özer

Demir eksikli?i anemisi hastalari{dotless}nda serum lipid düzeylerinin de?erlendirilmesi]

Objective: Several metabolic pathways are affected by the reduction in the amount of iron in iron deficiency anemia (IDA). As a result, some hormonal control mechanisms, especially carbohydrates, proteins, nucleic acid metabolism, are influenced. In this study, we aimed to investigate the effect of IDA on serum lipid profile. Method: Files of 30 patients with IDA and 30 healthy people (both groups aged 18-60), who consulted to internal medicine and gastroenterology clinic in Nami{dotless}k Kemal University Faculty of Medicine, were scanned. The lipid and blood parameters of these people as well as their demographics were recorded. Results: While serum total cholesterol and low-density lipoprotein (LDL) levels were markedly lower in IDA cases than in controls, serum triglyceride, high-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) levels did not differ in patients with IDA compared with the control group. Conclusion: It was observed that serum total cholesterol and LDL levels, whose main content is cholesterol, were decreased in IDA. We consider that reduction of iron levels changes cholesterol metabolism

Serum YKL-40 level is correlated with apnea hypopnea index in patients with obstructive sleep apnea syndrome

OBJECTIVE: Obstructive sleep apnea syndrome (OSAS) has been associated with elevated biochemical markers of inflammation. Although the exact mechanism is unknown, both sleep deprivation and hypoxemia are believed to be important causative factors. YKL-40, also known as chitinase-like protein, has been shown to be related to various inflammatory conditions including atherosclerosis, diabetes, cancer and asthma. The present study aimed to evaluate the relationship between YKL-40 levels and the Apnea Hypopnea Index (AHI) in patients with obstructive sleep apnea syndrome. PATIENTS AND METHODS: The study was conducted at the Sleep Unit of the Namik Kemal University Research Center. From January 2013 to December 2013, 120 patients diagnosed with OSAS by polysomnography and 40 subjects without OSAS were recruited. Patients in both groups were matched by age, sex, and body mass index (BM!). They were further divided into groups of mild, moderate and severe OSAS based on their AHI value. Serum YKL-40 concentrations were measured by the enzyme linked immunosorbent assay (ELISA). RESULTS: OSAS patients showed significantly elevated YKL-40 levels compared to the control group; 102,05 (23.14) pg/ml in the control group vs. 144.81 (65.53) pg/ml in the OSAS group. A Spearman correlation analysis showed that serum YKL-40 levels were significantly and positively correlated with AHI (r = 0.434, p < 0.001) and oxygen desaturation index (r = 0.374, p < 0.001). CONCLUSIONS: The study demonstrated that high serum YKL-40 levels correlated with the severity of OSAS and might serve as a nonspecific biomarker for prediction and progression of the disease

Asti{dotless}mli{dotless} çocuklarda tedavi sonrasi{dotless} total IgE, CRP ve tam kan sayi{dotless}m parametrelerinin de?erlendirilmesi]

Objective: We aimed to study if inhaled corticosteroid and inhaled beta 2 agonist treatment to 2-18 years old children with asthma resulted in recovery in serum total IgE, CRP, and whole blood count levels and/or to evaluate the effect of treatment in comparison to healthy children. Methods: Data regarding pre and post treatment serum total IgE, CRP, and hemogram levels of 2-18 years old, 99 children with asthma, who received inhaled corticosteroid and inhaled beta 2 agonist treatment and who applied to Nami{dotless}k Kemal University Research and Practice Hospital Pediatrics Clinic, were obtained through file scanning. Data regarding demographics and serum total IgE, CRP and hemogram levels of 99 healthy children in control group were also obtained through file scanning. Results: In children with asthma, levels of serum total IgE, lymphocyte, eosinophil and basophil counts and percentages were significantly increased compared to healthy controls, and they were significantly decreased after treatment to the levels of healthy controls. Serum CRP levels, neutrophil counts and percentages were significantly decreased compared to healthy controls, and they were significantly increased after treatment. Conclusions: Inhaled steroid and beta 2 antagonist treatment to children with asthma resulted in recovery in levels of IgE, CRP, and some whole blood count parameters through decreasing inflammation with its anti-inflammatory effect

Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome

Aim: Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients. Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits. Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups. Conclusion: These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS