A Ni(II) dinuclear complex bridged by end-on azide-N and phenolate-O atoms: spectral interpretation, magnetism and biological study

A new dinuclear complex, [Ni(L)(μ1,1-N3)Ni(L)(OH2)2]·ClO4(1), has been synthesized. It shows the presence of ferromagnetic interactions and is endowed with both anti-mycobacterial and anticancer properties

Anticancer and antituberculosis effects of 5-fluoro1H-indole-2,3-dione 3-thiosemicarbazones

Background and Aims: The aim of this study was to screen the in vitro anticancer/antituberculosis activities of 5-fluoro1-methyl/ethyl-1H-indole-2,3-dione 3-thiosemicarbazones. Methods: A549/U-87MG cell lines were used for the anticancer activity of the compounds, while CCD-19Lu cell line was used to determine their cytotoxic effects. In antituberculosis activity studies using MTB H37Rv cell line, BJ cell line was used to determine the cytotoxic effects. MTT assay was used to obtain IC50 values. Results: 6a, 6b, 6g, 6h, 6l, 6n, 7c, 7k and 7l were found to be highly effective against A549 cell line compared to cisplatin whereas 6d, 6h, 6l, 6n, 7d and 7f were found to be effective against U-87MG cell line compared to cisplatin. It was also determined that 6a, 6b and 7l did not show cytotoxic effects on CCD-19Lu cell line. The antituberculosis effects of the compounds were investigated against MTB H37Rv cell groups using rifampicin as standard. It was determined that 6b, 6c, 6g-k, 6n, 7b, 7j and 7l have near-standard activity and 6b, 7b and 7l were not cytotoxic on BJ cell line. Conclusion: While determining effective compounds in anticancer studies, it was concluded that active compounds can be reached by modifications in compounds in antituberculosis studies

The sociodemographic characteristics and psychiatric profiles of the accused persons who committed crime by means of firearms

Amaç: Çalışmada, ateşli silah ile suç işlediği iddia edilen bireylerin ceza sorumluluğu yönünden değerlendirilmesi ve bu tür suçların azaltılması yönünde alınabilecek önlemlerin tartışılması amaçlanmıştır. Yöntem: Bu amaçla hazırlanan anket formu, ateşli silahla suç işlediği iddia edilen ve mahkemeler tarafından Adli Tıp Kurumu 4. İhtisas Kurulu'na ceza sorumluluğunun olup olmadığının değerlendirilmesi amacıyla gönderilen olgulardan görüşmeyi kabul eden 50 olguya uygulanmıştır. Sonuçlar: Olguların 48'i (%96) erkek olup, 28'i (%56) 21-40 yaş arasında idi. Otuz altı olgu (%72) evli olup, 27 olgunun (%54) kısa namlulu silah kullanarak suç işlediği, 33 olgunun (%66) kullandığı ateşli silahın ruhsatsız olduğu belirlendi. Olguların 35'inin (%70) adam öldürme, dokuzunun (%18) adam yaralama veya adam öldürmeye girişim suçlarını işlediği iddia edilmekteydi. Cinayetlerin 12'sinin (%24) eş öldürme şeklinde olduğu, 12 olgunun (%24) sabıkalı olduğu görüldü. Kurulda yapılan değerlendirmede 22 olgunun (%44) ceza sorumluluğunun olmadığı kararına varıldı. Ceza sorumluluğu olmadığına karar verilen olgulardan altısının (%27.3) silah ruhsatının bulunduğu dikkati çekti. Tartışma: Ateşli silah kullanımı ile suç işleyen saldırganların profillerinin belirlenmesi, bu tip saldırıların önlenmesinde yol gösterici olacaktır. Ruhsat almak isteyen kişilerin psikiyatrik muayenesi, tehlikelilik ölçütlerinin değerlendirilmesi açısından önem taşımaktadır. Konunun diğer ayağını sivil toplum kuruluşları ve medyanın da desteği sağlanarak konu hakkında toplumun bilinçlenmesinin sağlanması, silahsızlanmanın özendirilmesi oluşturmaktadır. Diğer yönden, silah ruhsatının bu konuda özelleşmiş merkezlerde verilmesi, daha bilimsel ve standardize bir uygulamaya zemin hazırlayacaktırObjective: In this study, it is aimed to evaluate the individuals who were accused of committing crime by means of firearms in terms of their competency to stand trial and to discuss preventive measures can be taken in order to reduce such crimes. Methods: The survey form that was prepared for this purpose applied to 50 subjects that der. It was observed that 12 of the murders (24%) occurred as spouse-killing, 12 of the subjects (24%) had criminal records. It was determined as a result of evaluation conducted by the Committee that 22 subjects (44%) did not have competency to stand trial. 6 of the subjects (27%) with no competence to stand trial possessed gun license. Discussion: Determining the profiles of perpetrators who commits crimes by using firearms will be instructive to prevent these kinds of assaults. Psychiatric examination of who applies for a gun license presents great importance in terms of evaluating riskiness criteria. Assuring societal awareness by ensuring support of Civil Society Organizations and mass media, and encouraging disarmament are other side of the issue. Furthermore, issuing firearm licenses in specialized agencies will lay the groundwork for more scientific and standardize

The sociodemographic characteristics and psychiatric profiles of the accused persons who committed crime by means of firearms

Objective: In this study, it is aimed to evaluate the individuals who were accused of committing crime by means of firearms in terms of their competency to stand trial and to discuss preventive measures can be taken in order to reduce such crimes. Methods: The survey form that was prepared for this purpose applied to 50 subjects that accepted to interview out of accused persons, who were forwarded to Forensic Medicine Institution 4th Expertise Committee by court of law with accusation of committing crimes by means of firearms, to be evaluated in terms of their competency to stand trial. Results: Forty-eight of the subjects (96%) were male, 28 of them (56%) were between 21 and 40 years old. It is determined that 36 of the subjects (72%) were married, 27 of them (54%) committed crime by using short-barreled weapons and 33 of them (66%) used unregistered firearms. It was claimed that 35 of the subjects (70%) had committed murder; nine of them (18%) had committed attempted murder. It was observed that 12 of the murders (24%) occurred as spouse-killing, 12 of the subjects (24%) had criminal records. It was determined as a result of evaluation conducted by the Committee that 22 subjects (44%) did not have competency to stand trial. 6 of the subjects (27%) with no competence to stand trial possessed gun license. Discussion: Determining the profiles of perpetrators who commits crimes by using firearms will be instructive to prevent these kinds of assaults. Psychiatric examination of who applies for a gun license presents great importance in terms of evaluating riskiness criteria. Assuring societal awareness by ensuring support of Civil Society Organizations and mass media, and encouraging disarmament are other side of the issue. Furthermore, issuing firearm licenses in specialized agencies will lay the groundwork for more scientific and standardized practice

Pyrazole Incorporated New Thiosemicarbazones: Design, Synthesis and Investigation of DPP-4 Inhibitory Effects

Dipeptidyl peptidase-4 (DPP-4) inhibition has been recognized as a promising approach to develop safe and potent antidiabetic agents for the management of type 2 diabetes. In this context, new thiosemicarbazones (2a–o) were prepared efficiently by the reaction of aromatic aldehydes with 4-[4-(1H-pyrazol-1-yl)phenyl]thiosemicarbazide (1), which was obtained via the reaction of 4-(1H-pyrazol-1-yl)phenyl isothiocyanate with hydrazine hydrate. Compounds 2a–o were evaluated for their DPP-4 inhibitory effects based on a convenient fluorescence-based assay. 4-[4-(1H-pyrazol-1-yl)phenyl]-1-(4-bromobenzylidene)thiosemicarbazide (2f) was identified as the most effective DPP-4 inhibitor in this series with an IC50 value of 1.266 ± 0.264 nM when compared with sitagliptin (IC50 = 4.380 ± 0.319 nM). MTT test was carried out to assess the cytotoxic effects of compounds 2a–o on NIH/3T3 mouse embryonic fibroblast (normal) cell line. According to cytotoxicity assay, compound 2f showed cytotoxicity towards NIH/3T3 cell line with an IC50 value higher than 500 µM pointing out its favourable safety profile. Molecular docking studies indicated that compound 2f presented π-π interactions with Arg358 and Tyr666 via pyrazole scaffold and 4-bromophenyl substituent, respectively. Overall, in vitro and in silico studies put emphasis on that compound 2f attracts a great notice as a drug-like DPP-4 inhibitor for further antidiabetic research

Analysis and comparison of domestic femicide cases in the cities of Diyarbakir & Tekirdag, Turkey: A preliminary study

Court decision files from 2007 to 2012 were examined retrospectively in the Criminal High Courts of Diyarbakir and Tekirdag to analyse and compare domestic femicides in Diyarbakir and Tekirdag, Turkey, according to different fundamental characteristics. In total, 58 assailants were convicted of 50 femicides during this period. There were no so-called 'honour killings' in Tekirdag, while 16 (37.2%) of the homicides were honour killings in Diyarbakir. Policies to prevent violence against women, extending the means of access to post-violence services and reinforcing the law, policies and action plans to end this type of violence could be effective in decreasing cases of domestic femicide. (C) 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved

Customary Homicides in Diyarbakir Province

This study presents an analysis of the causes of so-called honor killings in the context of customary homicide and a discussion of preventive measures. Finalized case files of customary homicide between January 1, 2007 and December 31, 2012 were retrospectively examined in Diyarbakir Province, Turkey. Of a total of 28 case victims, 17 (60.7%) were females and 11 (39.3%) were males. All perpetrators were male. There was a significant difference between male and female victims in terms of economic independence (p=0.000). A direct blood relationship or relationship by marriage (such as brother-in-law) was found to have a significant association with the gender of the victim (p<0.001). Multilevel educational activities targeting a transformation of the perception of women by society, replacement of patriarchal models with more modern attitudes, and encouragement of individuality may represent effective strategies that may help reduce the number of customary homicide, which represents a multifaceted problem

Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents

In an effort to develop potent antimicrobial agents, new thiosemicarbazone derivatives were synthesized via the reaction of 4-[4-(trifluoromethyl)phenyl]thiosemicarbazide with aromatic aldehydes. The compounds were evaluated for their inhibitory effects on pathogenic bacteria and yeasts using the CLSI broth microdilution method. Microplate Alamar Blue Assay was also carried out to determine the antimycobacterial activities of the compounds against Mycobacterium tuberculosis H37Rv. Among these derivatives, compounds 5 and 11 were more effective against Enterococcus faecalis (ATCC 29212) than chloramphenicol, whereas compounds 1, 2, and 12 and chloramphenicol showed the same level of antibacterial activity against E. faecalis. Moreover, compound 2 and chloramphenicol exhibited the same level of antibacterial activity against Staphylococcus aureus. On the other hand, the most potent anticandidal derivatives were found as compounds 2 and 5. These derivatives and ketoconazole exhibited the same level of antifungal activity against Candida glabrata. According to the Microplate Alamar Blue Assay, the tested compounds showed weak to moderate antitubercular activity

A New phenoxido/trifluoroacetato bridged heterometallic Ni<SUP>II</SUP><SUB>2</SUB>sbnd Cu<SUP>II</SUP> derivative: Structure, EPR interpretation and DFT computation

International audienceThe trinuclear heterometallicNi2II-CuII complex,[Ni2(L)2(CF3COO)2Cu] (1) isafforded incorporating a tetradentate Schiff base precursor,H2L [where H2L =N,N?-bis(salicylidene)-1,3-propanediamine]. In 1, the two terminalNiII atoms are linked to the central CuII by asyn-anti bridging trifluroacetate and a double phenoxido bridge, givingrise to a linear structure. The EPR spectra show that the trinuclearstructure remains unchanged in non-coordinating solvents, whereas in DMFand DMSO the resonances of mononuclear CuII species with anaxial symmetry and a well-resolved hyperfine structure are observed. DFTcalculations reveal that the spin Hamiltonian parameters aregz 2.22 and Az 176.4 × 10-4cm-1, which are in good agreement with the experimentalvalues. The biological outcome of complex 1 on the viability ofdifferent human carcinoma cells are analyzed by MTT assay and theresults suggest that it induces a decrease in cell-population growthwith apoptosis