Symmetry restoration and quantumness reestablishment

A realistic quantum many-body system, characterized by a generic microscopic Hamiltonian, is accessible only through approximation methods. The mean field theories, as the simplest practices of approximation methods, commonly serve as a powerful tool, but unfortunately often violate the symmetry of the Hamiltonian. The conventional BCS theory, as an excellent mean field approach, violates the particle number conservation and completely erases quantumness characterized by concurrence and quantum discord between different modes. We restore the symmetry by using the projected BCS theory and the exact numerical solution and find that the lost quantumness is synchronously reestablished. We show that while entanglement remains unchanged with the particle numbers, quantum discord behaves as an extensive quantity with respect to the system size. Surprisingly, discord is hardly dependent on the interaction strengths. The new feature of discord offers promising applications in modern quantum technologies.Comment: 17 pages and 3 figure

排卵功能障碍性不孕症患者的中医五态人格及焦虑分析

Objective: Finding out the relationship between five-pattern personality and anxiety 、depression characteristics of the DOI patients. Methods: 200 DOI patients were selected in the Infertility Specialist of Guangzhou Liwan District Hospital of Chinese Medicine，at the same time, researchers choose normal women as controls. Respondents filled in the Five-pattern Personality Scales、SAS、SDS and general information questionnaire. Results: The proportion of shaoyin personality of the DOI patients(50%) is significantly higher than the normal women(22%). And no yin and yang personality was observed in patients with DOI. The SAS and SDS score of the DOI patients, listed in descending order, is as follow, taiyin personality、shaoyin personality、taiyang personality、shaoyang personality、yin and yang personality. Conclusion: The main five-pattern personality of DOI is shaoyin personality. The patients of the taiyin and shaoyin personality are more likely to have the characteristics of anxiety and depression.目的  探究排卵功能障碍性不孕症患者不同中医五态人格类型与焦虑、抑郁情绪的关联性。方法  确诊为排卵功能障碍性不孕症患者200例，同时在本院选择正常已育妇女作为对照组。采用《五态人格量表》、《焦虑自评量表（SAS）》、《抑郁自评量表（SDS）》及一般资料问卷进行调查。结果  排卵功能障碍性不孕症组中少阴型中医人格（50%）明显高于正常妇女组（22%），且没有出现阴阳平和型中医人格。不孕症组中太阳、少阳、少阴、太阴型中医人格的焦虑、抑郁总分4组间不全相等（P＜0.001）。结论  排卵功能障碍性不孕症患者以少阴型中医人格为主，且太阴、少阴型中医人格的患者更易出现高焦虑、高抑郁

Surface Immobilization of Redox-Labile Fluorescent Probes: Enabling Single-Cell Co-Profiling of Aerobic Glycolysis and Oncogenic Protein Signaling Activities.

An analytical method is described for profiling lactate production in single cells via the use of coupled enzyme reactions on surface-grafted resazurin molecules. The immobilization of the redox-labile probes was achieved through chemical modifications on resazurin, followed by bio-orthogonal click reactions. The lactate detection was demonstrated to be sensitive and specific. The method was incorporated into a single-cell barcode chip for simultaneous quantification of aerobic glycolysis activities and oncogenic signaling phosphoproteins in cancer. The interplay between glycolysis and oncogenic signaling activities was interrogated on a glioblastoma cell line. Results revealed a drug-induced oncogenic signaling reliance accompanying shifted metabolic paradigms. A drug combination that exploits this induced reliance exhibited synergistic effects in growth inhibition

Phylogenetic and molecular characterization of coxsackievirus A24 variant isolates from a 2010 acute hemorrhagic conjunctivitis outbreak in Guangdong, China

<p>Abstract</p> <p>Background</p> <p>Acute hemorrhagic conjunctivitis is a common disease in China. As a notifiable disease, cases are registered by ophthalmologists on the AHC surveillance system. An AHC outbreak caused by CA24v was observed in Guangdong Province in 2007 by the National Disease Supervision Information Management System. Three years later, a larger outbreak occurred in Guangdong during the August-October period (2010). To characterize the outbreak and compare the genetic diversity of CA24v, which was determined to be the cause of the outbreak, the epidemiology and the molecular characterization of CA24v were analyzed in this study.</p> <p>Results</p> <p>A total of 69,635 cases were reported in the outbreak. 73.5% of index cases originated from students, children in kindergarten and factory workers, with the ≦ 9 age group at the highest risk. The male to female ratio was 1.84:1 among 0-19 years. 56 conjunctival swabs were collected to identify the causative agent from five cities with the AHC outbreak. 30 virus strains were isolated, and two of the genomes had the highest identity values (95.8%) with CA24v genomes. Four CA24v genotypes were identified by phylogenetic analysis for the VP1 and 3C regions. CA24v which caused the outbreak belonged to genotype IV. Furthermore, full nucleotide sequences for four representative isolates in 2010 and 2007 were determined and compared. 20 aa mutations, two nt insertions and one nt deletion were observed in the open reading frame, with 5'- and 3'- UTR respectively between them.</p> <p>Conclusions</p> <p>CA24v was determined to be the pathogen causing the outbreak and belongs to genotype IV. VP1 is more informative than 3C^Profor describing molecular epidemiology and we hypothesize that accumulative mutations may have promoted the outbreak.</p

Effects of tumor metabolic microenvironment on regulatory T cells

Recent studies have shown that on one hand, tumors need to obtain a sufficient energy supply, and on the other hand they must evade the body’s immune surveillance. Because of their metabolic reprogramming characteristics, tumors can modify the physicochemical properties of the microenvironment, which in turn affects the biological characteristics of the cells infiltrating them. Regulatory T cells (Tregs) are a subset of T cells that regulate immune responses in the body. They exist in large quantities in the tumor microenvironment and exert immunosuppressive effects. The main effect of tumor microenvironment on Tregs is to promote their differentiation, proliferation, secretion of immunosuppressive factors, and chemotactic recruitment to play a role in immunosuppression in tumor tissues. This review focuses on cell metabolism reprogramming and the most significant features of the tumor microenvironment relative to the functional effects on Tregs, highlighting our understanding of the mechanisms of tumor immune evasion and providing new directions for tumor immunotherapy

Properties and Asteroseismological analysis of a new ZZ ceti discovered by TMTS

Tsinghua university-Ma Huateng Telescope for Survey (TMTS) aims to discover rapidly evolving transients by monitoring the northern sky. The TMTS catalog is cross-matched with the white dwarf (WD) catalog of Gaia EDR3, and light curves of more than a thousand WD candidates are obtained so far. Among them, the WD TMTS J23450729+5813146 (hereafter J2345) is one interesting common source. Based on the light curves from the TMTS and follow-up photometric observations, periods of 967.113 s, 973.734 s, 881.525 s, 843.458 s, 806.916 s and 678.273 s are identified. In addition, the TESS observations suggest a 3.39 h period but this can be attributed to the rotation of a comoving M dwarf located within 3". The spectroscopic observation indicates that this WD is DA type with Teff = 11778+/-617K,log g = 8.38+/-0.31,mass=0.84+/-0.20Msun and age=0.704+/-0.377 Gyrs. Asteroseismological analysis reveals a global best-fit solution of Teff =12110+/-10K and mass=0.760+/-0.005Msun,consistent with the spectral fitting results, and Oxygen and Carbon abundances in the core center are 0.73 and 0.27, respectively. The distance derived from the intrinsic luminosity given by asteroseismology is 93 parsec, which is in agreement with the distance of 98 parsec from Gaia DR3. Additionally, kinematic study shows that this WD is likely a thick disk star. The mass of its zero-age main-sequence mass is estimated to be 3.08 Msun and has a main-sequence plus cooling age of roughly 900 Myrs.Comment: 10 pages, 10 figures, accepted for publication in MNRA

Variable white dwarfs in TMTS: Asteroseismological analysis of a ZZ Ceti star, TMTS J17184064+2524314

The Tsinghua University-Ma Huateng Telescope for Survey (TMTS) has been constantly monitoring the northern sky since 2020 in search of rapidly variable stars. To find variable white dwarfs (WDs), the TMTS catalog is cross-matched with the WD catalog of Gaia EDR3, resulting in over 3000 light curves of WD candidates. The WD TMTS J17184064+2524314 (hereafter J1718) is the second ZZ~Ceti star discovered among these common sources. Based on the light curves from TMTS, follow-up photometric observations, and TESS, 10 periods and 3 combination periods are detected. A rotation period of $25.12\pm0.18$ hr is derived, according to the identified rotational splitting. Our spectroscopic observation indicates that this WD belongs to DA type with $T_{\rm eff}=11,670\pm604$ K, log $g=8.16\pm0.36$, $M = 0.70\pm0.23$ M$_{\odot}$, and age=$0.51\pm0.34$ Gyr. Based on core-parameterized asteroseismological model grids ($\geqslant$ 14 million), we derive a best-fit solution of $T_{\rm eff}=11,640\pm20$ K, log $g=8.267\pm0.008$, and $M = 0.750\pm0.005$ M$_{\odot}$ for J1718, consistent with the spectral fitting results. For this WD, the corresponding carbon and oxygen abundances in the core are 0.43 and 0.57, respectively. The distance derived from the intrinsic luminosity given by asteroseismology is $64\pm15$ pc, in accord with the distance of $70.1\pm0.2$ pc from Gaia DR3 within the uncertainties.Comment: 11 pages, 8 figures, Accepted for publication in MNRAS. arXiv admin note: text overlap with arXiv:2305.1158