Atteinte hépatique au cours de la maladie de Rendu-Osler: à propos d’un cas et revue de la littérature

Patiente âgée de 48 ans était hospitalisée pour une cholestase asymptomatique hépatique. Elle rapportait une histoire personnelle et familiale d’épistaxis récidivante. Le bilan biologique révélait une anémie ferriprive et une cholestase modérée. Les sérologies virales ainsi que les anticorps anti tissu hépatique étaient négatifs. Le scanner abdominal objectivait de multiples shunts artério-veineux dans la région sous-capsulaire du foie. Le diagnostic d’une atteinte hépatique dans le cadre d’un Rendu Osler était retenu. Un traitement martial était prescrit et une surveillance biologique et morphologique du foie était entreprise.The Pan African Medical Journal 2016;2

Multifocal bone tuberculosis simulating metastasis

Abstract Multiple skeletal tuberculosis can be the first sign of tuberculosis. In such cases, physicians should consider tuberculosis diagnosis and take biopsies for anatomopathological evidence to make the correct diagnosis

Acute acalculous cholecystitis complicating chemotherapy for acute myeloblastic leukemia

Acute acalculous cholecystitis is a rare complication in the treatment of acute myeloblastic leukemia. Diagnosis of acute acalculous cholecystitis remains difficult during neutropenic period. We present two acute myeloblastic leukemia patients that developed acute acalculous cholecystitis during chemotherapy-induced neutropenia. They suffered from fever, vomiting and acute pain in the epigastrium. Ultrasound demonstrated an acalculous gallbladder. Surgical management was required in one patient and conservative treatment was attempted in the other patient. None treatment measures were effective and two patients died. Acute acalculous cholecystitis is a serious complication in neutropenic patients. Earlier diagnosis could have expedited the management of these patients

Resistant Invasive Aspergillosis in an Autosomal Recessive Chronic Granulomatous Disease.

International audienceChronic granulomatous disease (CGD) is an inherited immunodeficiency characterized by severe bacterial and fungal infections. Invasive aspergillosis and other rare mold diseases are the leading causes of mortality. We report one case of CGD revealed by retropharyngeal abscess. On evolution, the patient developed an invasive aspergillosis resistant to treatment

Successful Conservative Management of Pancreatico-Colonic Fistula

Background: Internal fistula with adjacent viscera during acute pancreatitis is a rare complication. Due to their anatomic localization, colon, duodenum or stomach may be involved. Pancreatico-colonic fi stula is associated with a higher septic risk and surgery is usually mandatory.Results and main findings: We report a new case in 71-year-old man diagnosed by CT with rectal water soluble contrast media and managed conservatively. To our knowledge, this is the second case in the literature treated in this way.Conclusion: Conservative treatment may be offered to selected patients who have a rapid improvement of symptoms associated with a signifi cant regression of the collection.</p

MRI features in 17 patients with l2 hydroxyglutaric aciduria

l-2-Hydroxyglutaric (l-2-HG) aciduria is a rare inherited metabolic disease usually observed in children. Patients present a very slowly progressive deterioration with cerebellar ataxia, mild or severe mental retardation, and various other clinical signs including extrapyramidal and pyramidal symptoms, and seizures Goffette et al. [1]. This leukencephalopathy was first described in 1980 Duran et al. [2]. Brain magnetic resonance imaging (MRI) demonstrates nonspecific subcortical white matter (WM) loss, cerebellar atrophy and changes in dentate nuclei and putamen Steenweg et al. [3]. The diagnosis is highlighted by increased levels of l-2-HG in body fluids such as urine and cerebrospinal fluid.The purpose of this study is to retrospectively describe the brain MRI features in l-2-HG aciduria. Keywords: l-2-Hydroxyglutaric aciduria, Leukoencephalopathy, MRI, Spectroscop

Case report: Management challenges of late diagnosed 17‐alpha hydroxylase deficiency

Abstract Herein we report the intriguing case of a 42‐year‐old woman presenting with grade three hypertension, severe hypokalemia and primary amenorrhea, which revealed to be the complete form of 17 alphahydroxylase deficiency. We also discuss the challenging therapeutic approach as well as the outcomes and the follow‐up of this patient

Iatrogenic neonatal bladder perforation

Neonatal bladder rupture is rare as a complication of bladder obstruction due to abnormal anatomy or iatrogenic causes. The present study describes the case of a 3-day-old infant with ascites due to bladder perforation secondary probably to manual decompression of the bladder. The infant underwent successful surgical repair of the perforation

Resistant Invasive Aspergillosis in an Autosomal Recessive Chronic Granulomatous Disease

International audienceChronic granulomatous disease (CGD) is an inherited immunodeficiency characterized by severe bacterial and fungal infections. Invasive aspergillosis and other rare mold diseases are the leading causes of mortality. We report one case of CGD revealed by retropharyngeal abscess. On evolution, the patient developed an invasive aspergillosis resistant to treatment