1,541 research outputs found

    The Atomic and Electronic Structure of Liquid N- Methylformamide as Determined from Diffraction Experiments

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    The structure of liquid N-methylformamide (NMF) has been investigated using synchrotron radiation at 77 and 95 keV. The use of high energy photons has several advantages, in this case especially the large accessible momentum transfer range, the low absorption and the direct comparability with neutron diffraction. The range of momentum transfer covered is 0.6 \AA1<^{-1} < Q <<24.0 \AA1^{-1}. Neutron diffraction data on the same sample in the same momentum transfer range have been published previously. In that study two differently isotope - substituted species were investigated. In order to compare neutron and photon diffraction data properly Reverse Monte Carlo (RMC-) simulations have been performed. Some modifications had to be added to the standard RMC- code introducing different constraints for inter- and intramolecular distances as these distances partly overlap in liquid NMF. RMC- simulations having only the neutron data as input were carried out in order to test the quality of the X-ray data. The photon structure factor calculated from the RMC- configurations is found to agree well with the present experimental data, while it deviates considerably from earlier X-ray work using low energy photons (17 keV). Finally we discuss whether the different interaction mechanisms of neutrons and photons can be used to directly access the electronic structure in the liquid. Evidence is presented that the elastic self scattering part of liquid NMF is changed with respect to the independent atom approximation. This modification can be accounted for by a simple charged atoms model.Comment: Accepted for publication in Molecular Physics, LaTex file, 12 pages, figures not include

    Modulation of human JAK-STAT pathway signaling by functionally conserved regulators

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    Both the core JAK-STAT pathway components and their in vivo roles have been widely conserved between vertebrates and invertebrate models such as Drosophila melanogaster. Misregulation of JAK-STAT pathway activity has also been identified as a key factor in the development of multiple human malignancies. Recently, whole genome RNA interference (RNAi) screens in cultured Drosophila cells have identified both positively and negatively acting JAK-STAT pathway regulators. Here, we describe the analysis of 73 human genes representing homologs of 56 Drosophila genes originally identified by genome-wide RNAi screening as regulators of JAK-STAT signaling. Using assays for human STAT1 and STAT3 protein levels and phosphorylation status, as well as assays measuring the expression of endogenous STAT1 and STAT3 transcriptional targets, we have tested siRNAs targeting these 73 human genes and have identified potential JAK-STAT pathway regulatory roles in 69 (95%) of these. The genes identified represent a wide range of human JAK-STAT pathway regulators and include genes not previously known to modulate this signaling cascade. These results underline the value of model system based approaches for the identification of pathway regulators and have led to the identification of loci whose misregulation may ultimately be implicated in JAK-STAT pathway-mediated human disease

    Numerical Bifurcation Analysis of Conformal Formulations of the Einstein Constraints

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    The Einstein constraint equations have been the subject of study for more than fifty years. The introduction of the conformal method in the 1970's as a parameterization of initial data for the Einstein equations led to increased interest in the development of a complete solution theory for the constraints, with the theory for constant mean curvature (CMC) spatial slices and closed manifolds completely developed by 1995. The first general non-CMC existence result was establish by Holst et al. in 2008, with extensions to rough data by Holst et al. in 2009, and to vacuum spacetimes by Maxwell in 2009. The non-CMC theory remains mostly open; moreover, recent work of Maxwell on specific symmetry models sheds light on fundamental non-uniqueness problems with the conformal method as a parameterization in non-CMC settings. In parallel with these mathematical developments, computational physicists have uncovered surprising behavior in numerical solutions to the extended conformal thin sandwich formulation of the Einstein constraints. In particular, numerical evidence suggests the existence of multiple solutions with a quadratic fold, and a recent analysis of a simplified model supports this conclusion. In this article, we examine this apparent bifurcation phenomena in a methodical way, using modern techniques in bifurcation theory and in numerical homotopy methods. We first review the evidence for the presence of bifurcation in the Hamiltonian constraint in the time-symmetric case. We give a brief introduction to the mathematical framework for analyzing bifurcation phenomena, and then develop the main ideas behind the construction of numerical homotopy, or path-following, methods in the analysis of bifurcation phenomena. We then apply the continuation software package AUTO to this problem, and verify the presence of the fold with homotopy-based numerical methods.Comment: 13 pages, 4 figures. Final revision for publication, added material on physical implication

    Far-from-constant mean curvature solutions of Einstein's constraint equations with positive Yamabe metrics

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    In this article we develop some new existence results for the Einstein constraint equations using the Lichnerowicz-York conformal rescaling method. The mean extrinsic curvature is taken to be an arbitrary smooth function without restrictions on the size of its spatial derivatives, so that it can be arbitrarily far from constant. The rescaled background metric belongs to the positive Yamabe class, and the freely specifiable part of the data given by the traceless-transverse part of the rescaled extrinsic curvature and the matter fields are taken to be sufficiently small, with the matter energy density not identically zero. Using topological fixed-point arguments and global barrier constructions, we then establish existence of solutions to the constraints. Two recent advances in the analysis of the Einstein constraint equations make this result possible: A new type of topological fixed-point argument without smallness conditions on spatial derivatives of the mean extrinsic curvature, and a new construction of global super-solutions for the Hamiltonian constraint that is similarly free of such conditions on the mean extrinsic curvature. For clarity, we present our results only for strong solutions on closed manifolds. However, our results also hold for weak solutions and for other cases such as compact manifolds with boundary; these generalizations will appear elsewhere. The existence results presented here for the Einstein constraints are apparently the first such results that do not require smallness conditions on spatial derivatives of the mean extrinsic curvature.Comment: 4 pages, no figures, accepted for publication in Physical Review Letters. (Abstract shortenned and other minor changes reflecting v4 version of arXiv:0712.0798

    Hubble Tarantula Treasury Project: Unraveling Tarantula's Web. II. Optical and Near Infrared Star Formation History of the Starburst Cluster NGC 2070 in 30 Doradus

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    We present a study of the recent star formation of 30 Doradus in the Large Magellanic Cloud (LMC) using the panchromatic imaging survey Hubble Tarantula Treasury Project (HTTP). In this paper we focus on the stars within 20 pc of the center of the massive ionizing cluster of 30 Doradus, NGC 2070. We recovered the star formation history by comparing deep optical and NIR color-magnitude diagrams (CMDs) with state-of-the-art synthetic CMDs generated with the latest PARSEC models, which include all stellar phases from pre-main sequence to post- main sequence. For the first time in this region we are able to measure the star formation using intermediate and low mass stars simultaneously. Our results suggest that NGC2070 experienced a prolonged activity. In particular, we find that the star formation in the region: i) exceeded the average LMC rate ~ 20 Myr ago; ii) accelerated dramatically ~ 7 Myr ago; and iii) reached a peak value 1-3 Myr ago. We did not find significant deviations from a Kroupa initial mass function down to 0.5 Msun. The average internal reddening E(B-V) is found to be between 0.3 and 0.4 mag.Comment: Submitted to Ap

    Detailed Spectroscopic and Photometric Analysis of DQ White Dwarfs

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    We present an analysis of spectroscopic and photometric data for cool DQ white dwarfs based on improved model atmosphere calculations. In particular, we revise the atmospheric parameters of the trigonometric parallax sample of Bergeron et al.(2001), and discuss the astrophysical implications on the temperature scale and mean mass, as well as the chemical evolution of these stars. We also analyze 40 new DQ stars discovered in the first data release of the Sloan Digital Sky Survey.Comment: 6 pages,3 figures, 14th European Workshop on White Dwarfs, ASP Conference Series, in pres

    The Newtonian Limit for Asymptotically Flat Solutions of the Vlasov-Einstein System

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    It is shown that there exist families of asymptotically flat solutions of the Einstein equations coupled to the Vlasov equation describing a collisionless gas which have a Newtonian limit. These are sufficiently general to confirm that for this matter model as many families of this type exist as would be expected on the basis of physical intuition. A central role in the proof is played by energy estimates in unweighted Sobolev spaces for a wave equation satisfied by the second fundamental form of a maximal foliation.Comment: 24 pages, plain TE

    A theory of intense-field dynamic alignment and high harmonic generation from coherently rotating molecules and interpretation of intense-field ultrafast pump-probe experiments

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    A theory of ultra-fast pump-probe experiments proposed by us earlier [F.H.M. Faisal et al., Phys. Rev. Lett. 98, 143001 (2007) and F.H.M. Faisal and A. Abdurrouf, Phys. Rev. Lett. 100, 123005 (2008)] is developed here fully and applied to investigate the phenomena of dynamic alignment and high harmonic generation (HHG) from coherently rotating linear molecules. The theory provides essentially analytical results for the signals that allow us to investigate the simultaneous dependence of the HHG signals on the two externally available control parameters, namely, the relative angle between the polarizations, and the delay-time between the two pulses. It is applied to investigate the characteristics of high harmonic emission from nitrogen and oxygen molecules that have been observed experimentally in a number of laboratories. The results obtained both in the time-domain and in the frequency-domain are compared with the observed characteristics as well as directly with the data and are found to agree remarkably well. In addition we have predicted the existence of a "magic" polarization angle at which all modulations of the harmonic emission from nitrogen molecule changes to a steady emission at the harmonic frequency. Among other things we have also shown a correlation between the existence of the "magic" or critical polarization angles and the symmetry of the active molecular orbitals, that is deemed to be useful in connection with the "inverse problem" of molecular imaging from the HHG data.Comment: 31 pages, 22 figures, and 140 equation

    Unital Quantum Channels - Convex Structure and Revivals of Birkhoff's Theorem

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    The set of doubly-stochastic quantum channels and its subset of mixtures of unitaries are investigated. We provide a detailed analysis of their structure together with computable criteria for the separation of the two sets. When applied to O(d)-covariant channels this leads to a complete characterization and reveals a remarkable feature: instances of channels which are not in the convex hull of unitaries can return to it when either taking finitely many copies of them or supplementing with a completely depolarizing channel. In these scenarios this implies that a channel whose noise initially resists any environment-assisted attempt of correction can become perfectly correctable.Comment: 31 page
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