La sobrecarga de información percibida por los estudiantes universitarios y su influencia en el síndrome de respuesta inmediata al smartphone durante la pandemia de la COVID-19: Tomando la perspectiva de la personalidad

The COVID-19 pandemic has affected university students’ learning and social interaction to a large level, causing different degrees of negative emotions and made them extremely sensitive to smartphone information. However, little is known about the link between personalities, perceived information overload (PIO) and smartphone immediate response syndrome (SIRS) during students' learning process in this specific emergency social context. Therefore, based on the person-environment fit model, this study investigated 482 university students from mainland China during the epidemic by a snowball sampling approach, and analyzed the relationship between their personalities, PIO and SIRS by structural equation modeling. Results indicated that individuals with extraversion and neuroticism formed SIRS from different psychological paths. PIO plays a partial mediating role between neuroticism and SIRS and a fully mediating role between extraversion and SIRS. These findings validate the association among individual personality, PIO and SIRS in the non-conventional environment and highlights the difference exist in cellphone-related psychological path between extraverted and neurotic students. Therefore, it is recommended that PIO should be controlled in a targeted manner for individuals with different personality and guide them using cellphones rationally during the epidemic.La pandemia causada por la COVID-19 ha afectado en gran medida al aprendizaje y a la interacción social de los estudiantes universitarios, provocando emociones negativas de diferentes grados y haciéndoles extremadamente sensibles a la información de los smartphones. Sin embargo, se sabe poco sobre la relación entre la personalidad, la sobrecarga de información percibida (SIP) y el síndrome de respuesta inmediata al smartphone (SIRS) durante el proceso de aprendizaje de los estudiantes en este contexto social de emergencia específico. Por lo tanto, basándose en el modelo de ajuste persona-ambiente, este estudio investigó a 482 estudiantes universitarios de China continental durante la epidemia mediante un enfoque de muestreo de bola de nieve, y analizó la relación entre su personalidad, SIP y SIRS mediante un modelo de ecuaciones estructurales. Los resultados indicaron que los individuos con extraversión y neuroticismo formaron el SIRS a partir de diferentes vías psicológicas. La SIP desempeña un papel mediador parcial entre el neuroticismo y el SIRS y un papel totalmente mediador entre la extraversión y el SIRS. Estos resultados validan la asociación entre la personalidad individual, la SIP y el SIRS en el entorno no convencional y pone de manifiesto la diferencia que existe en la trayectoria psicológica relacionada con el teléfono móvil entre los estudiantes extrovertidos y los neuróticos. Por lo tanto, se recomienda controlar la SIP de forma específica para los individuos con personalidad diferente y guiarlos en el uso racional de los teléfonos móviles durante la epidemia

University students' perceived information overload mediates smartphone immediate response syndrome during COVID-19 outbreak: Taking the perspective of personality

The COVID-19 pandemic has affected university students’ learning and social interaction to a large level, causing different degrees of negative emotions and made them extremely sensitive to smartphone information. However, little is known about the link between personalities, perceived information overload (PIO) and smartphone immediate response syndrome (SIRS) during students' learning process in this specific emergency social context. Therefore, based on the person-environment fit model, this study investigated 482 university students from mainland China during the epidemic by a snowball sampling approach, and analyzed the relationship between their personalities, PIO and SIRS by structural equation modeling. Results indicated that individuals with extraversion and neuroticism formed SIRS from different psychological paths. PIO plays a partial mediating role between neuroticism and SIRS and a fully mediating role between extraversion and SIRS. These findings validate the association among individual personality, PIO and SIRS in the non-conventional environment and highlights the difference exist in cellphone-related psychological path between extraverted and neurotic students. Therefore, it is recommended that PIO should be controlled in a targeted manner for individuals with different personality and guide them using cellphones rationally during the epidemic

Calculation of Sound Insulation for Hybrid CLT Fabricated with Lumber and LVL and comparison with experimental data.

The insulated predictions were carried out for LVL, CLT and HCLT in order to evaluate their sound properties, in which the theoretical value of sound insulation was predicted by regarding the substances in wood cell wall as equivalence to specific medium based on Biot model, and the wood anatomical characteristics, such as the length and diameter of tracheid, diameter of pit, and porosity, were taken into account for determining the equivalent density and bulk modulus of elasticity of wood cell wall. By comparing the tested and predicted values of sound insulation, the conclusion were drawn as follows: the predicted values of sound insulation were significantly correlated with the tested values for LVL, CLT and HCLT. As for Masson pine and Southern pine, the adjacent of earlywood and latewood was considered as sandwich structure for the calculation of sound insulation. Meanwhile, the bonding interface was creatively introduced to improve the accuracy of sound insulation prediction. The transfer function involved in sound insulation prediction provide an effective method to characterize the sound insulation volume of wood composite in construction and decoration areas

Comparison of Bonding Performance Between Plywood and Laminated Veneer Lumber Induced by High Voltage Electrostatic Field.

High voltage electrostatic field (HVEF) was applied in order to improve wood surface characteristics, bonding and mechanical properties of wood composites. Masson pine (Pinus massoniana Lamp.) plywood and laminated veneer lumber (LVL) were selected in this study. Surface characteristics were conducted by the electron spin resonance (ESR) and X-ray photoelectron spectra (XPS). Bonding interphase and mechanical properties were investigated by fluorescence microscopy and vertical density profile (VDP), bonding strength, wood failure ratio, MOE and MOR. The results indicated that more increments were obtained in free radicals, O/C ratios and C2-C4 components. This is because electrons broke more wood chemical groups and new ions occurred among wood surface under HVEF. Significantly decreased PF adhesive penetration depth (PD) and increased density at bonding interphase was achieved in HVEF treated composites. More decrease of PD and increment of density were observed in plywood than that of LVL. This was attributed to cross linked wood fibers among bonding interphase in plywood. Mechanical properties of bonding strength, wood failure ratio, MOE and MOR were significantly increased under HVEF treatment both for two composites. Higher bonding strength, MOE and MOR were obtained in plywood and their increments were as 98.53%, 33.33%, 18.55% and 12.72%

A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell

DNA double-strand breaks (DSBs) represent the most toxic DNA damage arisen from endogenous and exogenous genotoxic stresses and are known to be repaired by either homologous recombination or nonhomologous end-joining processes. Although many proteins have been identified to participate in either of the processes, the whole processes still remain elusive. Polycomb group (PcG) proteins are epigenetic chromatin modifiers involved in gene silencing, cancer development and the maintenance of embryonic and adult stem cells. By screening proteins responding to DNA damage using laser micro-irradiation, we found that PHF1, a human homolog of Drosophila polycomb-like, Pcl, protein, was recruited to DSBs immediately after irradiation and dissociated within 10 min. The accumulation at DSBs is Ku70/Ku80-dependent, and knockdown of PHF1 leads to X-ray sensitivity and increases the frequency of homologous recombination in HeLa cell. We found that PHF1 interacts physically with Ku70/Ku80, suggesting that PHF1 promotes nonhomologous end-joining processes. Furthermore, we found that PHF1 interacts with a number of proteins involved in DNA damage responses, RAD50, SMC1, DHX9 and p53, further suggesting that PHF1, besides the function in PcG, is involved in genome maintenance processes

Subharmonic bifurcations and chaotic dynamics of an air damping completely inelastic bouncing ball

We investigate the dynamics of a plastic ball on a vibrated platform in air by introducing air damping effect into the completely inelastic bouncing ball model. The air damping gives rise to larger saddle-node bifurcation points and a chaos confirmed by the largest Lyapunov exponent of a one-dimensional discrete mapping. The calculated bifurcation point distribution shows that the periodic motion of the ball is suppressed and a chaos emerges earlier for an increasing air damping. When the reset mechanism and the linear stability which cause periodic motion of the ball both collapse, the investigated system is fully chaotic

Paclitaxel-Loaded Mixed Micelles Enhance Ovarian Cancer Therapy through Extracellular pH-Triggered PEG Detachment and Endosomal Escape

Although PEGylation allows a drug delivery vehicle to have prolonged blood circulation time, it faces the problem of reduced cellular uptake. Removal of the polyethylene glycol (PEG)-shell at the appropriate time through tumor-microenvironment triggers could be a feasible solution to this problem. Here, paclitaxel (PTX)-loaded mixed micelles (PTX-mM) self-assembled from stearate-modified hyaluronic acid (SHA), mPEG-<i>b</i>-poly­(β-amino ester) (mPEG-<i>b</i>-PAE), and ethylene acetyl-<i>b</i>-poly­(β-amino ester) (EA-<i>b</i>-PAE) were developed. In the preparation of PTX-mM, SHA micelles were coated with EA-<i>b</i>-PAE followed by coloading of PTX and mPEG-<i>b</i>-PAE. PTX-mM were capable of extracellular pH-triggered PEG-detachment and poly­(β-amino ester) (PAE)-mediated endosomal escape. When the pH was changed from pH 7.4 to pH 6.8, the particle size of PTX-mM significantly decreased from 97.5 ± 4.4 to 71.5 ± 2.3 nm. It also resulted in rapid and complete release of mPEG-<i>b</i>-PAE from PTX-mM as monitored using quartz crystal microbalance (QCM) technology. PTX-mM capable of PEG detachment provided significant enhancement of PTX accumulation in SKOV-3 cells compared to PEG nondetachable PTX-mM. Interestingly, intracellular transport studies using confocal laser scanning microscopy (CLSM) showed that EA-<i>b</i>-PAE could promote the escape of micelles from endolysosomes. The half-maximal inhibitory concentration (IC₅₀) of PTX-mM against SKOV-3 cells was 5.7 μg/mL, and PTX-mM containing 20 μg/mL of PTX induced apoptosis in 53.0% of the cell population. PTX-mM exhibited a highly prolonged elimination half-life (<i>t</i>_1/2, 2.83 ± 0.37 h) and improved area under the curve (AUC, 7724.82 ± 1190.75 ng/mL/h) than the PTX-loaded SHA micelles (PTX-M). Furthermore, PTX-mM showed the highest tumor inhibition rate (64.9%) and the longest survival time (53 days) against the SKOV-3 ovarian cancer xenograft models among all formulations. Taken together, the results suggested that PTX-mM have potential as an efficient anticancer formulation in treatment of ovarian cancer