513 research outputs found
PET-based dose painting in non-small cell lung cancer: Comparing uniform dose escalation with boosting hypoxic and metabolically active sub-volumes.
BACKGROUND AND PURPOSE: We compared two imaging biomarkers for dose-escalation in patients with advanced non-small cell lung cancer (NSCLC). Treatment plans boosting metabolically active sub-volumes defined by FDG-PET or hypoxic sub-volumes defined by HX4-PET were compared with boosting the entire tumour.MATERIALS AND METHODS: Ten NSCLC patients underwent FDG- and HX4-PET/CT scans prior to radiotherapy. Three isotoxic dose-escalation plans were compared per patient: plan A, boosting the primary tumour (PTVprim); plan B, boosting sub-volume with FDG >50% SUVmax (PTVFDG); plan C, boosting..
A Pair Polarimeter for Linearly Polarized High Energy Photons
A high quality beam of linearly polarized photons of several GeV will become
available with the coherent bremsstrahlung technique at JLab. We have developed
a polarimeter which requires about two meters of the beam line, has an
analyzing power of 20% and an efficiency of 0.02%. The layout and first results
of a polarimeter test on the laser back-scattering photon beam at SPring-8/LEPS
are presented
Spectroscopy of 13B via the 13C(t,3He) reaction at 115 AMeV
Gamow-Teller and dipole transitions to final states in 13B were studied via
the 13C(t,3He) reaction at Et = 115 AMeV. Besides the strong Gamow-Teller
transition to the 13B ground state, a weaker Gamow-Teller transition to a state
at 3.6 MeV was found. This state was assigned a spin-parity of 3/2- by
comparison with shell-model calculations using the WBP and WBT interactions
which were modified to allow for mixing between nhw and (n+2)hw configurations.
This assignment agrees with a recent result from a lifetime measurement of
excited states in 13B. The shell-model calculations also explained the
relatively large spectroscopic strength measured for a low-lying 1/2+ state at
4.83 MeV in 13B. The cross sections for dipole transitions up to Ex(13B)= 20
MeV excited via the 13C(t,3He) reaction were also compared with the shell-model
calculations. The theoretical cross sections exceeded the data by a factor of
about 1.8, which might indicate that the dipole excitations are "quenched".
Uncertainties in the reaction calculations complicate that interpretation.Comment: 11 pages, 6 figure
Time-of-flight mass measurements of neutron-rich chromium isotopes up to N = 40 and implications for the accreted neutron star crust
We present the mass excesses of 59-64Cr, obtained from recent time-of-flight
nuclear mass measurements at the National Superconducting Cyclotron Laboratory
at Michigan State University. The mass of 64Cr is determined for the first
time, with an atomic mass excess of -33.48(44) MeV. We find a significantly
different two-neutron separation energy S2n trend for neutron-rich isotopes of
chromium, removing the previously observed enhancement in binding at N=38.
Additionally, we extend the S2n trend for chromium to N=40, revealing behavior
consistent with the previously identified island of inversion in this region.
We compare our results to state-of-the-art shell-model calculations performed
with a modified Lenzi-Nowacki-Poves-Sieja interaction in the fp shell,
including the g9/2 and d5/2 orbits for the neutron valence space. We employ our
result for the mass of 64Cr in accreted neutron star crust network calculations
and find a reduction in the strength and depth of electron-capture heating from
the A=64 isobaric chain, resulting in a cooler than expected accreted neutron
star crust. This reduced heating is found to be due to the >1-MeV reduction in
binding for 64Cr with respect to values from commonly used global mass models.Comment: Accepted to Physical Review
Spectroscopy of Ti and the systematic behavior of low energy octupole states in Ca and Ti isotopes
Excited states of the nucleus Ti have been studied, via both
inverse-kinematics proton scattering and one-neutron knockout from Ti by
a liquid hydrogen target, using the GRETINA -ray tracking array.
Inelastic proton-scattering cross sections and deformation lengths have been
determined. A low-lying octupole state has been tentatively identified in
Ti for the first time. A comparison of results on low-energy
octupole states in the neutron-rich Ca and Ti isotopes with the results of
Random Phase Approximation calculations demonstrates that the observed
systematic behavior of these states is unexpected.Comment: 7 pages, 8 figure
Spectroscopy of Ti and the systematic behavior of low energy octupole states in Ca and Ti isotopes
Excited states of the nucleus Ti have been studied, via both
inverse-kinematics proton scattering and one-neutron knockout from Ti by
a liquid hydrogen target, using the GRETINA -ray tracking array.
Inelastic proton-scattering cross sections and deformation lengths have been
determined. A low-lying octupole state has been tentatively identified in
Ti for the first time. A comparison of results on low-energy
octupole states in the neutron-rich Ca and Ti isotopes with the results of
Random Phase Approximation calculations demonstrates that the observed
systematic behavior of these states is unexpected.Comment: 7 pages, 8 figure
Structural study of the type II 3-dehydroquinate dehydratase from Actinobacillus pleuropneumoniae
9 pages, 7 figures, 2 tables.The structure of the type II dehydroquinate dehydratase (DHQase) from Actinobacillus pleuropneumoniae, the third enzyme of the shikimate pathway, has been determined. Crystals diffracting to 1.7 Ã… were obtained in space and on earth using the counter-diffusion technique. The structure was solved using molecular replacement and refined to high resolution. The overall structure of the dodecameric enzyme is described and compared with structures of DHQases from other bacteria. DHQases contain a flexible loop that presumably closes over the active site upon substrate binding. The enzyme can exist in an open or closed conformation. The present structure displays the open conformation, with a sulfate anion bound in the active site. The availability of this structure opens a route to structure-based antibiotics targetting this pathogenic bacterium.We thank Professor Kabsch for providing XDS free of charge. We acknowledge the support of the European Space Agency and the European Community Action to Research Infrastructure
Action of the Improving Human Potential Programme to the EMBL Hamburg Outstation, contract No. HPRI-CT-1999-00017. We thank Olivier Minster (ESA) for his support of
space science. The authors acknowledge the excellent work of Dr Eva ManÄ as in managing the logistics concerning the space mission. We thank Viscount Dirk Frimout for his support for space crystallization experiments.Peer reviewe
Low-lying level structure of Cu and its implications on the rp process
The low-lying energy levels of proton-rich Cu have been extracted
using in-beam -ray spectroscopy with the state-of-the-art -ray
tracking array GRETINA in conjunction with the S800 spectrograph at the
National Superconducting Cyclotron Laboratory at Michigan State University.
Excited states in Cu serve as resonances in the
Ni(p,)Cu reaction, which is a part of the rp-process in
type I x-ray bursts. To resolve existing ambiguities in the reaction Q-value, a
more localized IMME mass fit is used resulting in ~keV. We derive
the first experimentally-constrained thermonuclear reaction rate for
Ni(p,)Cu. We find that, with this new rate, the
rp-process may bypass the Ni waiting point via the Ni(p,)
reaction for typical x-ray burst conditions with a branching of up to
40. We also identify additional nuclear physics uncertainties that
need to be addressed before drawing final conclusions about the rp-process
reaction flow in the Ni region.Comment: 8 pages, accepted for Phys. Rev.
- …