The neurobiology of circadian rhythms

Purpose of review There is growing awareness of the importance of circadian rhythmicity in various research fields. Exciting developments are ongoing in the field of circadian neurobiology linked to sleep, food intake, and memory. With the current knowledge of critical ‘clock genes’ (genes found to be involved in the generation of circadian rhythms) and novel techniques for imaging cyclic events in brain and peripheral tissue, this field of research is rapidly expanding. We reviewed only some of the highlights of the past year, and placed these findings into a mutual circadian perspective. Recent findings Recent findings on the organization of the circadian clock systems are addressed, ranging from the retina to the suprachiasmatic nucleus and peripheral organs. Novel developments in sleep, food intake, and memory research linked to circadian aspects are discussed. Summary The neurobiology of circadian rhythms is pivotal to the orchestration of the temporal organization of an individual’s physiology and behavior. Endogenous circadian timing systems underlie coupling and uncoupling mechanisms of many neuronal and physiological processes, the latter possibly inducing health risks to the organism. The integration of sleep, food intake and memory in a circadian setting has clear potential as a systems neurobiology line of research.

Stochastic modeling of soil salinity

A minimalist stochastic model of primary soil salinity is proposed, in which the rate of soil salinization is determined by the balance between dry and wet salt deposition and the intermittent leaching events caused by rainfall events. The long term probability density functions of salt mass and concentration are found by reducing the coupled soil moisture and salt mass balance equation to a single stochastic differential equation driven by multiplicative Poisson noise. The novel analytical solutions provide insight on the interplay of the main soil, plant and climate parameters responsible for long-term soil salinization. In particular, they show the existence of two distinct regimes, one where the mean salt mass remains nearly constant (or decreases) with increasing rainfall frequency, and another where mean salt content increases markedly with increasing rainfall frequency. As a result, relatively small reductions of rainfall in drier climates may entail dramatic shifts in long-term soil salinization trends, with significant consequences e.g. for climate change impacts on rain-fed agricultur

A Distributed Object Model for CSCW in the Construction Industry

Information about products for the construction industry is increasingly often provided to designers in digital ways that enable them to apply the information directly in the design process. Digital product catalogues are provided using various media and formats and several initiatives are taken by the industry and by CAD developers to integrate this kind of information into CAD systems. Generally, current practice is to distribute the information to designers, for example, by using CD-ROMs or a website where the information can be downloaded. In our research we recognise that distributing information in this manner detaches it from the business processes in the construction supply chain, which is a major disadvantage. The project presented in this paper concerns the implementation in the Dutch construction industry of a methodology for sharing product information through a distributed object model. The methodology, which is called Concept Modelling, forms a generic basis for the support of collaborative design, but is applied in this project to the integration of information from the supply chain in the design process. Through the distributed object model, design information and product information can be integrated while the actual data objects remain at their source. This enables the supply chain to provide information of a high semantic level to designers while keeping the control over the information and maintaining the relationship of the information with their business processes. The advantages of this approach in which information is shared, rather than exchanged, are numerous. Redundancy of information is minimised, consistency is improved, and updated information is available immediately. Moreover, design and construction processes can benefit significantly from the dynamic aspects of accessing information that is tied to business processes in the supply chain. For example, product selection during design can be based on latest information on product details, prices, production methods, and variants of products. This information can be provided to designers automatically and on demand

Solute Transport in Soil

Solute transport is of importance in view of the movement of nutrient elements, e.g. towards the plant root system, and because of a broad range of pollutants. Pollution is not necessarily man induced, but may be due to geological or geohydrological causes, e.g. in the cases of pollution with arsenic, and salt. For the polluting species, a distinction can be made between dissolved and immiscible, and between conservative and reactive. Dissolved pollutants (aqueous phase pollutants) will spread with the groundwater due to groundwater flow, diffusion and dispersion

Morris Water Maze Learning in Two Rat Strains Increases the Expression of the Polysialylated Form of the Neural Cell Adhesion Molecule in the Dentate Gyrus But Has No Effect on Hippocampal Neurogenesis

In the current study, the authors investigated whether Morris water maze learning induces alterations in hippocampal neurogenesis or neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus. Two frequently used rat strains, Wistar and Sprague–Dawley, were trained in the spatial or the nonspatial version of the water maze. Both training paradigms did not have an effect on survival of newly formed cells that were labeled 7–9 days prior to the training or on progenitor proliferation in the subgranular zone. However, the granule cell layer of the spatially trained rats contained significantly more positive cells of the polysialylated form of the NCAM. These data demonstrate that Morris water maze learning causes plastic change in the dentate gyrus without affecting hippocampal neurogenesis.

Фінансова політика держави і розвиток фінансового ринку в Україні

Розглянута координуюча роль інституту – держави через реалізацію відповідної фінансової політики у формуванні ефективно функціонуючого фінансового ринку в сучасній економічній системі

Discontinuities without discontinuity: The Weakly-enforced Slip Method

Tectonic faults are commonly modelled as Volterra or Somigliana dislocations in an elastic medium. Various solution methods exist for this problem. However, the methods used in practice are often limiting, motivated by reasons of computational efficiency rather than geophysical accuracy. A typical geophysical application involves inverse problems for which many different fault configurations need to be examined, each adding to the computational load. In practice, this precludes conventional finite-element methods, which suffer a large computational overhead on account of geometric changes. This paper presents a new non-conforming finite-element method based on weak imposition of the displacement discontinuity. The weak imposition of the discontinuity enables the application of approximation spaces that are independent of the dislocation geometry, thus enabling optimal reuse of computational components. Such reuse of computational components renders finite-element modeling a viable option for inverse problems in geophysical applications. A detailed analysis of the approximation properties of the new formulation is provided. The analysis is supported by numerical experiments in 2D and 3D.Comment: Submitted for publication in CMAM

Dutch dwellings

Applying Generative Design (GD) for dwelling is not very common but it opens up the possibility to study whether GD systems can reproduce existing design typologies. Dutch dwellings as an exemplification of a design typology are analysed using the SAR methodology. Building regulations are used as input to a GD system along with the typical requirements for a family house. The results show that not all existing typologies can exactly be reproduced, but the generated designs have a remarkable resemblance with Dutch dwellings. They also demonstrate that Dutch dwelling identity is at least partially encoded in Dutch building regulations. Coding of yet unknown architectural identities requires new GD metaphors to support the architect