Models of EMC filters

Cílem úvodu práce je vysvětlení základních pojmů odrušovacích filtrů a uvedení problémů, které se při návrhu a měření vlastností odrušovacích filtrů vyskytují. Jde hlavně o problém neurčitosti impedancí na vstupu a výstupu odrušovacího filtru. Je také představen současný stav možností měření vložného útlumu filtrů dle platných norem a uvedena motivace pro vytvoření modelů odrušovacích filtrů. Druhá část práce obsahuje kapitoly, které se zabývají prvky, ze kterých se odrušovací filtr skládá. Pozornost je zaměřena na parazitní vlastnosti těchto prvků a jejich modelování. Dále se zabývá popisem obvodového řešení filtru tak, aby bylo možno vyjádřit matematický popis pro útlum filtru. Je představena optimalizační metoda roje částic PSO. Její základní princip a názvosloví. Třetí část práce je věnována vlivům vlastních a parazitních obvodových prvků filtru na útlumovou charakteristiku. Vlivy jednotlivých prvků jsou demonstrovány v mnoha grafech. Je řešeno hledání činitele vazby k. Poslední část práce je věnována návrhu náhradních ekvivalentních obvodů s parazitními prvky pro asymetrický a symetrický měřicí systém. Byla ukázána souvislost mezi náhradními ekvivalentními obvody a útlumovou charakteristikou. Ze zlomů v útlumové charakteristice byly získány akumulační parazitní prvky.Basic problems of the EMI mains filter is explained in the introduction of this thesis. These problems appear during the measurement of insertion loss of filters and by design of EMI mains filter. The important problem is uncertainly of the terminating impedances. Eventualities measurement insertion loss of EMI mains filter and motivation of creation filter models are shown. The following part of this project shows the electronic components, from which are realized the EMI mains filter. Parasitic properties of these real devices are also discussed. The circuitry of EMI mains filter is described by the Modified Nodal Voltage Method. The optimization method called Participle Swarm Optimization is introduced, too. Basic principle and terminology are mentioned. The third part of this project is focused on the own filter and spurious components. Influence of own filter and spurious filters components on insertion loss curve are showed. Magnetic factor coefficient k is searched by the optimization method PSO. The last part of this thesis deals with creation of the alternative circuits with spurious filters components. The performances of the alternative circuits were compared with the measured data for symmetrical and asymmetrical measurement setup. The breakages in the insertion loss curve were used for determining the spurious components.

Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond

Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron. In this review, we explain the interaction of various flavonoid structures with Fe(II) and Fe(III) ions and critically discuss the influence of chelated ions on the flavonoid biochemical properties. In addition, specific biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been included in this review

Pentamethinium Salts Nanocomposite for Electrochemical Detection of Heparin

This study presents a simple route to heparin detection and develops a voltammetric approach using supramolecular principles and nanomaterials. Nanocomposites, including gold nanoparticles (AuNPs) and γ-substituted pentamethinium salts (PMS) deposited on a glass carbon (GC) electrode surface (GC/AuNPs/PMS) and covered by a plasticized poly(vinyl chloride) (PVC) membrane, are proposed for heparin detection. The conductivity of the nonconducting PVC-plasticized membrane is guaranteed by AuNPs, and the selectivity is provided by the interaction between γ-substituted PMS and anionic analytes. In order to extend the linear range, it is necessary to apply a solvent compatible with PVC-plasticized membrane, namely tetrahydrofuran. The proposed voltammetric sensor showed a concentration dependence from 1.72 up to 45.02 IU mL−1 heparin and was used for heparin detection in saline and biological samples with recovery of 95.1–100.9%

The Role of IL-6 in Cancer Cell Invasiveness and Metastasis—Overview and Therapeutic Opportunities

Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunity, including COVID-19. In this review, we summarise the role of IL-6 signalling pathways in cancer biology, with particular emphasis on cancer cell invasiveness and metastasis formation. Targeting principal components of IL-6 signalling (e.g., IL-6Rs, gp130, STAT3, NF-κB) is an intensively studied approach in preclinical cancer research. It is of significant translational potential; numerous studies strongly imply the remarkable potential of IL-6 signalling inhibitors, especially in metastasis suppression

Water soluble chromone Schiff base derivatives as fluorescence receptor for aluminium(III)

<p>A novel water-soluble chromone Schiff base derivatives bearing polyhydroxylated moiety were prepared and applied for specific recognition of metal ions in aqueous medium. Their selective fluorescence response to Al(III) over a variety of other biologically important metal ions were demonstrated. Electronic parameters of the sensors were also studied by quantum chemical computations.</p

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

Designing optimal (neo)adjuvant therapy is a crucial aspect of the treatment of non-small-cell lung carcinoma (NSCLC). Standard methods of chemotherapy, radiotherapy, and immunotherapy represent effective strategies for treatment. However, in some cases with high metastatic activity and high levels of circulating tumour cells (CTCs), the efficacy of standard treatment methods is insufficient and results in treatment failure and reduced patient survival. CTCs are seen not only as an isolated phenomenon but also a key inherent part of the formation of metastasis and a key factor in cancer death. This review discusses the impact of NSCLC therapy strategies based on a meta-analysis of clinical studies. In addition, possible therapeutic strategies for repression when standard methods fail, such as the administration of low-toxicity natural anticancer agents targeting these phenomena (curcumin and flavonoids), are also discussed. These strategies are presented in the context of key mechanisms of tumour biology with a strong influence on CTC spread and metastasis (mechanisms related to tumour-associated and -infiltrating cells, epithelial–mesenchymal transition, and migration of cancer cells)