92 research outputs found

    Pituitary Apoplexy Producing Internal Carotid Artery Compression: A Case Report

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    We report a case of pituitary apoplexy resulting in right internal carotid artery occlusion accompanied by hemiplegia and lethargy. A 43-yr-old man presented with a sudden onset of severe headache, visual disturbance and left hemiplegia. Investigations revealed a nodular mass, located in the sella and suprasellar portion and accompanied by compression of the optic chiasm. The mass compressed the bilateral cavernous sinuses, resulting in the obliteration of the cavernous portion of the right internal carotid artery. A border zone infarct in the right fronto-parietal region was found. Transsphenoidal tumor decompression following conservative therapy with fluid replacement and steroids was performed. Pathological examination revealed an almost completely infarcted pituitary adenoma. The patient's vision improved immediately after the decompression, and the motor weakness improved to grade IV+ within six months after the operation. Pituitary apoplexy resulting in internal carotid artery occlusion is rare. However, clinicians should be aware of the possibility and the appropriate management of such an occurrence

    Pituitary apoplexy: re-evaluation of risk factors for bleeding into pituitary adenomas and impact on outcome

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    Objective: To assess frequency, symptoms and outcome of pituitary apoplexy (PA) among pituitary adenoma patients, to gain better insight into risk factors for bleeding into pituitary adenoma, and to estimate the sequelae of PA by means of a matched control group. Method: By reviewing charts of 574 patients with pituitary adenoma we analysed incidence, symptoms and outcome of PA, and potential risk factors for developing PA by means of a control group (patients with pituitary adenoma without PA). Results: 42 suffered from PA; all had macroadenomas. 30/217 male (14%) and 12/179 female (7%) macroadenoma patients, 32/194 patients with clinically non-functioning (16.5%) and 10/202 with clinically active (5.0%) macroadenoma were affected. Antithrombotic therapy predisposed patients to PA (p = 0.026), diabetes mellitus and hypertension did not (p = 1.00). Patients with PA and pituitary adenoma patients without PA had similar frequencies of hypopituitarism (45 vs. 48%, p > 0.05) and visual field defects (38 vs. 55%, p > 0.05), but ophthalmoplegia was significantly more common (76 vs. 5%, p < 0.001) in patients with PA. Nearly all patients were treated by surgery; most recovered from ophthalmoplegia whereas visual function improved only moderately. Endocrine outcome was worse in patients with PA compared to patients without PA. Conclusions: Male gender and characteristics of the adenoma itself (especially tumour size and tumour type) rather than patient's cardiovascular risk factors such as diabetes and hypertension seem to predispose to PA; antithrombotic therapy may also be important

    Swarm Debugging: the Collective Intelligence on Interactive Debugging

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    One of the most important tasks in software maintenance is debugging. To start an interactive debugging session, developers usually set breakpoints in an integrated development environment and navigate through different paths in their debuggers. We started our work by asking what debugging information is useful to share among developers and study two pieces of information: breakpoints (and their locations) and sessions (debugging paths). To answer our question, we introduce the Swarm Debugging concept to frame the sharing of debugging information, the Swarm Debugging Infrastructure (SDI) with which practitioners and researchers can collect and share data about developers’ interactive debugging sessions, and the Swarm Debugging Global View (GV) to display debugging paths. Using the SDI, we conducted a large study with professional developers to understand how developers set breakpoints. Using the GV, we also analyzed professional developers in two studies and collected data about their debugging sessions. Our observations and the answers to our research questions suggest that sharing and visualizing debugging data can support debugging activities

    Reverse Engineering: A Cognitive Approach, a Case Study and a Tool. Ph.d. computer science

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    My supervisor, Tim Lethbridge, had a lot of influence on the ideas presented in this thesis. It has been a nice ride with him; we seem to agree always, my research just fitted nicely with his earlier research. He has been very supportive and helped a lot, particularly, at the level of quality of presentation and he never let me wait too long for any request. My father, Dr. Ali, who is a professor of philosophy and psychology, gave me valuable ideas and hard to find pointers into these domains; not only throughout this thesis but through a life long education. 2 Content

    Multiple Spitz naevi: the randomly distributed variant

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    Gestational pituitary apoplexy

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