213 research outputs found

    Optically-induced lensing effect on a Bose-Einstein condensate expanding in a moving lattice

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    We report the experimental observation of a lensing effect on a Bose-Einstein condensate expanding in a moving 1D optical lattice. The effect of the periodic potential can be described by an effective mass dependent on the condensate quasi-momentum. By changing the velocity of the atoms in the frame of the optical lattice we induce a focusing of the condensate along the lattice direction. The experimental results are compared with the numerical predictions of an effective 1D theoretical model. Besides, a precise band spectroscopy of the system is carried out by looking at the real-space propagation of the atomic wavepacket in the optical lattice.Comment: 5 pages, 4 figures; minor changes applied and typos corrected; a new paragraph added; some references updated; journal reference adde

    Strontium optical lattice clocks for practical realization of the metre and secondary representation of the second

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    We present a system of two independent strontium optical lattice standards probed with a single shared ultra-narrow laser. The absolute frequency of the clocks can be verified by the use of Er:fiber optical frequency comb with the GPS-disciplined Rb frequency standard. We report hertz-level spectroscopy of the clock line and measurements of frequency stability of the two strontium optical lattice clocks.Comment: This is an author-created, un-copyedited version of an article accepted for publication in Meas. Sci. Technol. The publisher is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at doi:10.1088/0957-0233/26/7/07520

    Free-fall expansion of finite-temperature Bose-Einstein condensed gas in the non Thomas-Fermi regime

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    We report on our study of the free-fall expansion of a finite-temperature Bose-Einstein condensed cloud of 87Rb. The experiments are performed with a variable total number of atoms while keeping constant the number of atoms in the condensate. The results provide evidence that the BEC dynamics depends on the interaction with thermal fraction. In particular, they provide experimental evidence that thermal cloud compresses the condensate.Comment: 8 pages, 4 figure

    Microscale to Manufacturing Scale-up of Cell-Free Cytokine Production—A New Approach for Shortening Protein Production Development Timelines

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    Engineering robust protein production and purification of correctly folded biotherapeutic proteins in cell-based systems is often challenging due to the requirements for maintaining complex cellular networks for cell viability and the need to develop associated downstream processes that reproducibly yield biopharmaceutical products with high product quality. Here, we present an alternative Escherichia coli-based open cell-free synthesis (OCFS) system that is optimized for predictable high-yield protein synthesis and folding at any scale with straightforward downstream purification processes. We describe how the linear scalability of OCFS allows rapid process optimization of parameters affecting extract activation, gene sequence optimization, and redox folding conditions for disulfide bond formation at microliter scales. Efficient and predictable high-level protein production can then be achieved using batch processes in standard bioreactors. We show how a fully bioactive protein produced by OCFS from optimized frozen extract can be purified directly using a streamlined purification process that yields a biologically active cytokine, human granulocyte-macrophage colony-stimulating factor, produced at titers of 700 mg/L in 10 h. These results represent a milestone for in vitro protein synthesis, with potential for the cGMP production of disulfide-bonded biotherapeutic proteins. Biotechnol. Bioeng. 2011; 108:1570–1578. © 2011 Wiley Periodicals, Inc

    On roughness measurement by angular speckle correlation

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    In this work, the influence of both characteristics of the lens and misalignment of the incident beams on roughness measurement is presented. To investigate how the focal length and diameter affect the degree of correlation between the speckle patterns, a set of experiments with different lenses is performed. On the other hand, the roughness when the beams separated by an amount are non-coincident at the same point on the sample is measured. To conclude the study, the uncertainty of the method is calculated

    Spatial heterodyne observations of water (SHOW) from a high-altitude airplane: characterization, performance, and first results

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    The Spatial Heterodyne Observations of Water instrument (SHOW) is a limb-sounding satellite prototype that utilizes the Spatial Heterodyne Spectroscopy (SHS) technique, operating in a limb-viewing configuration, to observe limb-scattered sunlight in a vibrational band of water vapour within a spectral window from 1363 to 1366&thinsp;nm. The goal is to retrieve high vertical and horizontal resolution measurements of water vapour in the upper troposphere and lower stratosphere. The prototype instrument has been configured for observations from NASA's ER-2 high-altitude airborne remote science airplane. Flying at a maximum altitude of ∼21.34&thinsp;km with a maximum speed of ∼760&thinsp;km&thinsp;h−1, the ER-2 provides a stable platform to simulate observations from a low-earth orbit satellite. Demonstration flights were performed from the ER-2 during an observation campaign from 15 to 22 July 2017. In this paper, we present the laboratory characterization work and the level 0 to level 1 processing of flight data that were obtained during an engineering flight performed on 18 July 2017. Water vapour profile retrievals are presented and compared to in situ radiosonde measurements made of the same approximate column of air. These measurements are used to validate the SHOW measurement concept and examine the sensitivity of the technique.</p

    Merged SAGE II, Ozone_cci and OMPS ozone profile dataset and evaluation of ozone trends in the stratosphere

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    In this paper, we present a merged dataset of ozone profiles from several satellite instruments: SAGE II on ERBS, GOMOS, SCIAMACHY and MIPAS on Envisat, OSIRIS on Odin, ACE-FTS on SCISAT, and OMPS on Suomi-NPP. The merged dataset is created in the framework of the European Space Agency Climate Change Initiative (Ozone_cci) with the aim of analyzing stratospheric ozone trends. For the merged dataset, we used the latest versions of the original ozone datasets. The datasets from the individual instruments have been extensively validated and intercompared; only those datasets which are in good agreement, and do not exhibit significant drifts with respect to collocated ground-based observations and with respect to each other, are used for merging. The long-term SAGE–CCI–OMPS dataset is created by computation and merging of deseasonalized anomalies from individual instruments. The merged SAGE–CCI–OMPS dataset consists of deseasonalized anomalies of ozone in 10° latitude bands from 90° S to 90° N and from 10 to 50 km in steps of 1 km covering the period from October 1984 to July 2016. This newly created dataset is used for evaluating ozone trends in the stratosphere through multiple linear regression. Negative ozone trends in the upper stratosphere are observed before 1997 and positive trends are found after 1997. The upper stratospheric trends are statistically significant at midlatitudes and indicate ozone recovery, as expected from the decrease of stratospheric halogens that started in the middle of the 1990s and stratospheric cooling
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