405 research outputs found

    Electric field induced strong localization of electrons on solid hydrogen surface: possible applications to quantum computing

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    Two-dimensional electron system on the liquid helium surface is one of the leading candidates for constructing large analog quantum computers (P.M. Platzman and M.I. Dykman, Science 284, 1967 (1999)). Similar electron systems on the surfaces of solid hydrogen or solid neon may have some important advantages with respect to electrons on liquid helium in quantum computing applications, such as larger state separation ΔE\Delta E, absence of propagating capillary waves (or ripplons), smaller vapor pressure, etc. As a result, it may operate at higher temperatures. Surface roughness is the main hurdle to overcome in building a realistic quantum computer using these states. Electric field induced strong localization of surface electrons is shown to be a convenient tool to characterize surface roughness.Comment: 4 pages, 3 figure

    SCIENTIFIC CONTRIBUTION OF PROFESSOR P. V. NIKOLSKY TO THE DEVELOPMENT OF DERMATOLOGY AND VENEROLOGY IN RUSSIA (DELICATED TO THE 150TH ANNIVERSARY OF HIS BIRTH)

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    The article contains some biographical information about professor P. V. Nikolsky, which reflects scientific and practical contribution to the development of native Dermatology and Venereology, to the organization of the Imperial Nikolaev’s University (Saratov) foundation and the becoming of dermatovenerological services in the USSR

    Design features of а ribbon wind power station

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    The article describes a ribbon wind power plant, belonging to the class of the wind turbine rotor. A feature of the installation is inclined rotation axis and a number of standardized modules. A distinctive feature is the modularity of wind turbines, i.e. the ability to create an installation of any capacity from tens of watts for domestic use up to tens of kW for settlements, infrastructure and various anti-crisis objectives.В статье описана ленточно-винтовая ветроэнергетическая установка, относящаяся к классу роторных ВЭУ. Особенностью установки является наклонная ось вращения и ряд унифицированных модулей. Отличительной чертой ВЭУ является модульность, т.е. возможность создания установки любой мощности от десятков Вт для бытовых нужд до десятков кВт для населенных пунктов, объектов инфраструктуры и различных антикризисных целей

    Development of human capital in the system of economic categories of work

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    Today, human capital is one of the main factors in the formation of the knowledge economy, which is the highest stage in the development of an innovative, post-industrial economy. The development of intellectual and spiritual capabilities of a person, as well as the accumulation of human capital, which has a strong influence on the productivity and quality of labor, becomes one of the priorities for the future development of the state. This article discusses the development of human capital in the system of economic categories of labor.peer-reviewe

    Assessment of the effect of pre-slaughter fasting period of young bulls on the qualitative characteristics of meat

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    The purpose of the study was to evaluate the effect of the technological operation “pre-slaughter fasting period” on the qualitative characteristics of the meat of young bulls. The studies were carried out in two groups of Ayrshire bulls of 18 months of age, with a live weight of 435 ± 3.25 kg: I (n = 10) – slaughter without fasting period at the slaughter station, II (n = 10) – slaughter with 24-hour fasting period at the slaughter station. The total distance from the farm to the animal weighing and slaughter station was 97 km, and the travel time was 1 hour 43 minutes. The ambient temperature at the time of transportation was minus 13-15 °C, air humidity was 79 %, wind speed was 6 m/s. It has been established that the technological operation in the form of fasting period during 24 hours after transportation affected the qualitative indicators of the longissimus dorsi muscle, namely, there increased: the dry matter content by 2.45 %, protein – by 2.64 %, glycogen concentration – by 38.9 %, moisture capacity – by 11.01 %, oleic fatty acid – by 2.65 % with a decrease in moisture content – by 2.48 %, pH – by 3.5 %, myristic fatty acid by 0.95 %, palmitoleic acid – by 0.42 %, stearic acid – by 1.35 % compared to the group of bulls without fasting period. Thus, pre-slaughter 24-hour fasting period of young bulls improves the qualitative characteristics of meat compared to animals slaughtered without it

    Dynamics of LINE-1 retrotransposon methylation levels in circulating DNA from lung cancer patients undergoing antitumor therapy

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    Malignant cell transformation is accompanied with abnormal DNA methylation, such as the hypermethylation of certain gene promoters and hypomethylation of retrotransposons. In particular, the hypomethylation of the human-specific family of LINE-1 retrotransposons was observed in lung cancer tissues. It is also known that the circulating DNA (cirDNA) of blood plasma and cell-surface-bound circulating DNA (csb-cirDNA) of cancer patients accumulate tumor-specific aberrantly methylated DNA fragments, which are currently considered to be valuable cancer markers. This work compares LINE-1 retrotransposon methylation patterns in cirDNA of 16 lung cancer patients before and after treatment. CirDNA was isolated from blood plasma, and csb-cirDNA fractions were obtained by successive elution with EDTA-containing phosphate buffered saline and trypsin. Concentrations of methylated LINE-1 region 1 copies (LINE-1-met) were assayed by real-time methylation-specific PCR. LINE-1 methylation levels were normalized to the concentration of LINE-1 region 2, which was independent of the methylation status (LINE-1-Ind). The concentrations of LINE-1-met and LINE-1-Ind in csb-cirDNA of lung cancer patients exhibited correlations before treatment (r = 0.54), after chemotherapy (r = 0.72), and after surgery (r = 0.83) (P 0.05, respectively). These results suggest a need for the further investigation of dynamic changes in levels of LINE-1 methylation depending on the antitumor therapy

    Conducting and automating the water Morris maze test in SPF conditions

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    The water Morris maze is the basic test to study the spatial ability to learn as well as spatial memory in laboratory rodents. It is a part of a series of tests necessary for behavioral phenotyping of mutant and transgenic mice. At the same time, conducting this test in SPF conditions must comply with very strict regulations concerning pathogen control. A white animal on the surface of whitened water is low contrast and this does not allow the animal to be traced automatically, which represents yet another major problem. A unique installation based on EthoStudio has been developed at the Institute of Cytology and Genetics SB RAS and the Institute of Automation and Electrometry SB RAS. This installation automates the process of tracing mice of any coat color in SPF conditions. This includes a setup to install a plastic water reservoir (110×40 cm), a digital camera and a light source. Water to fill the reservoir was sterilized using a Van Erp Blue Lagoon UV-C Tech 15000 ultraviolet decontaminator. The image of an animal was processed in a frame-by-frame fashion using the EthoStudio program, with the following parameters calculated: latent release time, route covered, cumulative distance to the platform and the time spent in the reservoir sectors. With this installation, we were able to study the spatial ability to learn and spatial memory in mice of the C57BL/6 strain and in mice of the C57BL/6/ Kaiso strain developed on the C57BL/6 background, with the gene encoding the methyl-DNA binding Kaiso protein knocked-out. It has been demonstrated that mice of these strains are able to learn to find the platform in the water Morris maze and have the location of the platform in their memory for at least the next four days
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