Generalized Effective Reducibility

We introduce two notions of effective reducibility for set-theoretical statements, based on computability with Ordinal Turing Machines (OTMs), one of which resembles Turing reducibility while the other is modelled after Weihrauch reducibility. We give sample applications by showing that certain (algebraic) constructions are not effective in the OTM-sense and considerung the effective equivalence of various versions of the axiom of choice

Gene expression profile of the skin in the 'hairpoor' (HrHp) mice by microarray analysis

<p>Abstract</p> <p>Background</p> <p>The transcriptional cofactor, Hairless (HR), acts as one of the key regulators of hair follicle cycling; the loss of function mutations is the cause of the expression of the hairless phenotype in humans and mice. Recently, we reported a new <it>Hr </it>mutant mouse called 'Hairpoor' (<it>Hr^Hp</it>). These mutants harbor a gain of the function mutation, T403A, in the <it>Hr </it>gene. This confers the overexpression of HR and <it>Hr^Hp</it>is an animal model of Marie Unna hereditary hypotrichosis in humans. In the present study, the expression profile of <it>Hr^Hp/Hr^Hp</it>skin was investigated using microarray analysis to identify genes whose expression was affected by the overexpression of HR.</p> <p>Results</p> <p>From 45,282 mouse probes, differential expressions in 43 (>2-fold), 306 (>1.5-fold), and 1861 genes (>1.2-fold) in skin from <it>Hr^Hp/Hr^Hp</it>mice were discovered and compared with skin from wild-type mice. Among the 1861 genes with a > 1.2-fold increase in expression, further analysis showed that the expression of eight genes known to have a close relationship with hair follicle development, ascertained by conducting real-time PCR on skin RNA produced during hair follicle morphogenesis (P0-P14), indicated that four genes, <it>Wif1</it>, <it>Casp14</it>, <it>Krt71</it>, and <it>Sfrp1</it>, showed a consistent expression pattern with respect to HR overexpression in vivo.</p> <p>Conclusion</p> <p><it>Wif1 </it>and <it>Casp14 </it>were found to be upregulated, whereas <it>Krt71 </it>and <it>Sfrp1 </it>were downregulated in cells overexpressing HR in transient transfection experiments on keratinocytes, suggesting that HR may transcriptionally regulate these genes. Further studies are required to understand the mechanism of this regulation by the HR cofactor.</p

Genome-Wide Search Reveals the Existence of a Limited Number of Thyroid Hormone Receptor Alpha Target Genes in Cerebellar Neurons

Thyroid hormone (T3) has a major influence on cerebellum post-natal development. The major phenotypic landmark of exposure to low levels of T3 during development (hypothyroidism) in the cerebellum is the retarded inward migration of the most numerous cell type, granular neurons. In order to identify the direct genetic regulation exerted by T3 on cerebellar neurons and their precursors, we used microarray RNA hybridization to perform a time course analysis of T3 induced gene expression in primary cultures of cerebellar neuronal cell. These experiments suggest that we identified a small set of genes which are directly regulated, both in vivo and in vitro, during cerebellum post-natal development. These modest changes suggest that T3 does not acts directly on granular neurons and mainly indirectly influences the cellular interactions taking place during development

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W archiwum Koła Pań Karaimskich w Haliczu zachował się tekst referatu wygłoszonego 24 listopada 1935 r. podczas obchodów 250 rocznicy przybycia z Derażna na Wołyniu uczonego męża Józefa syna Szemuela HaMaszbira

La música metal como recurso educativo para la enseñanza de la literatura española en secundaria

Treball Final de Màster Universitari en Professor/a d'Educació Secundària Obligatòria i Batxillerat, Formació Professional 2014/2015La música popular se sirve en ocasiones de la literatura para contextualizar sus canciones, y la música heavy metal no es una excepción. En este trabajo de investigación con orientación hermenéutica, demostramos a partir del análisis documental que este estilo musical, pese a todos los falsos prejuicios que lo asocian frecuentemente a personas carentes de cultura o sensibilidad, puede ser empleado como recurso para la didáctica de la literatura española en la educación secundaria. El motivo principal radica en que son numerosas las canciones de metal en castellano cuya temática coincide con contenidos prescritos por el currículum de literatura en español para esta etapa educativa