Evolution of Scholarly Communication: How Small and Medium-Sized Libraries are Adapting

For the transformation of scholarly publishing to succeed, it is imperative that small and medium-sized institutions are actively engaged in scholarly communication initiatives. This paper presents the results of a survey of scholarly communication initiatives at selected U.S institutions and discusses the influence of institutional variables on the approaches that are employed. The survey was designed to gather information comparable to a 2007 ARL (Association of Research Libraries) survey

Terapia Comunitária Integrativa para promoção da saúde em acadêmicos de uma Universidade da Terceira Idade

It is the presentation of the results verified in the scope of mental health, based on empirical research, through the application of soft care technology conceptualized as Integrative Community Therapy (ICT) circles in an academic community of the Open University of the Third Age (UNATI) of the Western Paraná State University/Foz do Iguaçu in partnership with the Extension Project of the Federal University of Latin American Integration “Integrating UNILA with conversation circles” from 05/04/18 to 05/10/18. The study demonstrated that the psychosocial methodology developed in the ICT circles has the potential to equip participants to face the crisis of integrity, mobilizing a protected scenario to wisely appreciate the path taken in their own lives, understanding and integrating the path of other participants, confronting the experiences, as conscience, from collective experience and overcoming challenges within the same generation.Se trata de la presentación de los resultados verificados en el ámbito de la salud mental, basados en la investigación empírica, a través de la aplicación de tecnología leve de cuidado conceptualizada como círculos de Terapia Comunitaria Integradora (TIC) en una comunidad académica de la Universidad Abierta de la Tercera Edad (UNATI) de la Universidad Estatal del Oeste del Paraná/ Foz do Iguaçu en asociación con el Proyecto de Extensión de la Universidad Federal de la Integración Latinoamericana "Integrando UNILA con círculos de conversación" en el período del 04/04/18 al 05/10/18 . El estudio demostró que la metodología psicosocial desarrollada en los círculos de TIC tiene el potencial de equiparar a los participantes para enfrentar la crisis de integridad, movilizando un escenario protegido para apreciar sabiamente el camino tomado en sus propias vidas, entendiendo e integrando el camino de otros participantes, confrontando las experiencias, como conciencia, de la experiencia colectiva y la superación de desafíos dentro de la misma generación.Trata-se da apresentação dos resultados verificados no âmbito da saúde mental, a partir de pesquisa empírica, mediante a aplicação da tecnologia leve de cuidado conceituada como rodas de Terapia Comunitária Integrativa (TCI) em uma comunidade acadêmica da Universidade Aberta da Terceira Idade (UNATI) da Universidade Estadual do Oeste do Paraná/Foz do Iguaçu em parceria com o Projeto de Extensão da Universidade Federal da Integração Latino-Americana “Integrando a UNILA com Rodas de Conversa” no período de 05/04/18 a 10/05/18. O estudo demonstrou que a metodologia psicossocial desenvolvida nas rodas de TCI tem potencial para instrumentalizar aos participantes o enfrentamento da crise da integridade, mobilizando cenário protegido para apreciar com sabedoria o caminho percorrido na própria vida, compreendendo e integrando o percurso dos demais participantes, confrontando as experiências, enquanto consciência, a partir da vivência coletiva e a superação dos desafios dentro de uma mesma geração

III-N optoelectronic devices: understanding the physics of electro-optical degradation

III-N optoelectronic devices are of great interest for many applications. Visible emitters (based on InGaN) are widely used in the lighting, display and automotive fields. Ultraviolet LEDs (based on AlGaN) are expected to be widely used for disinfection, medical treatments, surface curing and sensing. Photodetectors and solar cells based on InGaN are also of interest, thanks to their great robustness and wavelength tunability. III-N semiconductors are expected to be robust, thanks to the wide bandgap (allowing high temperature operation) and to the high breakdown field (favoring the robustness against electrostatic discharges and electrical overstress). However, InGaN- and AlGaN-based devices can show a significant degradation when submitted to long-term ageing. Several driving forces can contribute to the worsening of the electrical and optical characteristics, including the operating temperature, the current, and the rate of non-radiative recombination in the quantum wells. The goal of this paper is to discuss the physics of degradation of III-V devices, by presenting a set of recent case studies, evaluated in our laboratories

Deep defects in InGaN LEDs: modeling the impact on the electrical characteristics

Deep defects have a fundamental role in determining the electro-optical characteristics and in the efficiency of InGaN light-emitting diodes (LEDs). However, modeling their effect on the electrical characteristics of the LED is not straightforward. In this paper we analyze the impact of the defects on the electrical characteristics of LEDs: we analyze three single-quantum-well (SQW) InGaN/GaN LED wafers, which differ in the density of defects. Through steady-state photocapacitance (SSPC) and light-capacitance-voltage measurements, the energy levels of these deep defects and their concentrations have been estimated. By means of a simulation campaign, we show that these defects have a fundamental impact on the current voltage characteristic of LEDs, especially in the sub turn-on region. The model adopted takes into consideration trap assisted tunneling as the main mechanism responsible for current leakage in forward bias. For the first time, we use in simulations the defect parameters (concentration, energy) extracted from SSPC. In this way, we can reproduce with great accuracy the current-voltage characteristics of InGaN LEDs in a wide current range (from pA to mA). In addition, based on SSPC measurements, we demonstrate that the defect density in the active region scales with the QW thickness. This supports the hypothesis that defects are incorporated in In-containing layers, consistently with recent publications

Defects in III-N LEDs: experimental identification and impact on electro-optical characteristics

III-N light-emitting-diodes (LEDs) are subject of intense investigations, thanks to their high efficiency and great reliability. The quality of the semiconductor material has a significant impact on the electro-optical performance of LEDs: for this reason, a detailed characterization of defect properties and the modeling of the impact of defects on device performance are of fundamental importance. This presentation addresses this issue, by discussing a set of recent case studies on the topic; specifically, we focus on the experimental characterization of defects, and on the modeling of their impact on the electro-optical characteristics of the devices

Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome

Background: The low-density lipoprotein receptor (LDLR) in the liver is the major determinant of LDL-cholesterol levels in human plasma. The discovery of genes that regulate the activity of LDLR helps to identify pathomechanisms of hypercholesterolemia and novel therapeutic targets against atherosclerotic cardiovascular disease.Methods: We performed a genome-wide RNA interference screen for genes limiting the uptake of fluorescent LDL into Huh-7 hepatocarcinoma cells. Top hit genes were validated by in vitro experiments as well as analyses of datasets on gene expression and variants in human populations.Results: The knockdown of 54 genes significantly inhibited LDL uptake. Fifteen of them encode for components or interactors of the U2-spliceosome. Knocking down any one of 11 out of 15 genes resulted in the selective retention of intron 3 of LDLR. The translated LDLR fragment lacks 88% of the full length LDLR and is detectable neither in non-transfected cells nor in human plasma. The hepatic expression of the intron 3 retention transcript is increased in non-alcoholic fatty liver disease as well as after bariatric surgery. Its expression in blood cells correlates with LDL-cholesterol and age. Single nucleotide polymorphisms and three rare variants of one spliceosome gene, RBM25, are associated with LDL-cholesterol in the population and familial hypercholesterolemia, respectively. Compared to overexpression of wild type RBM25, overexpression of the three rare RBM25 mutants in Huh-7 cells led to lower LDL uptake.Conclusions: We identified a novel mechanism of post-transcriptional regulation of LDLR activity in humans and associations of genetic variants of RBM25 with LDL-cholesterol levels.</p

The Prolyl Isomerase Pin1 Modulates Development of CD8+ cDC in Mice

We have identified a novel role for Pin1 as a modulator of CD8+ cDC development. Consistent with reduced numbers of CD8+ cDC in Pin1-null mice, we find that the absence of Pin1 impairs CD8+ T cell proliferation in response to infection with Listeria monocytogenes. These data suggest that, via regulation of CD8+ cDC production, Pin1 may serve as an important modulator of adaptive immunity

A TECNOLOGIA COMO DISPOSITIVO DO ATENDIMENTO HUMANIZADO NA ATENÇÃO BÁSICA À SAÚDE

Over the years, it has been observed that technology has been advancing more and more and has contributed significantly to people's lives, as well as to important areas such as health, because, based on these tools, it becomes possible to develop care faster and more humanized to patients who seek primary health care to obtain medical assistance. Thus, the research aims to explain the relevance of technology as a device for humanized care in primary health care. The methodology used consisted of the literature review method in order to obtain concise information about the objective of the work, with articles published from 2019 to 2022 available on Scielo, Lilacs and PubMed. Researches that were lower than 2019 were excluded, as well as those whose content was not in Portuguese, which would make the researchers' verification and analysis process difficult. In this way, the results pointed to the benefits caused by technology, enabling better care in terms of medical consultations, exams and guidance to patients, making humanized care in primary health care an essential factor. Concluding on the need to expand technology as a humanized device in all primary health care units, considering that some locations do not have these tools, because, in addition to promoting effectiveness in terms of faster assistance, it enables the minimization queue for appointments and exams.Com o passar dos anos, observa-se que a tecnologia vem avançando cada vez mais e contribuído de forma significativa na vida das pessoas, como também para áreas importantes como a da saúde, pois, a partir dessas ferramentas que torna-se possível desenvolver atendimento mais rápidos e humanizado aos pacientes que buscam atenção básica de saúde para obter assistência médica. Assim, a pesquisa objetiva explicar sobre a relevância da tecnologia como dispositivo do atendimento humanizado na atenção básica à saúde. A metodologia utilizada consistiu no método revisão de literatura com o intuito de obter informações concisas a respeito do objetivo do trabalho, sendo inserido artigos publicados no período de 2019 a 2022 disponíveis na Scielo, Lilacs e PubMed. Sendo excluídas pesquisas que estavam inferior a 2019, bem como aquelas cujo conteúdo não era língua portuguesa, o que dificultaria o processo de verificação e análise dos pesquisadores. Dessa forma, os resultados apontaram sobre os benefícios ocasionados pela tecnologia, possibilitando melhores atendimentos em termos de consultas médicas, exames e orientações aos pacientes, tornando o atendimento humanizado na atenção básica à saúde como um fator imprescindível. Concluindo-se sobre a necessidade de ampliar a tecnologia como dispositivo humanizado em todas as unidades de atenção básica à saúde, tendo em vista que algumas localidades não dispõem dessas ferramentas, pois, além de promover eficácia em termos de assistência mais rápida, possibilita a minimização da fila de espera por atendimentos e exames