187 research outputs found
A Maximal Inequality for th Power of Stochastic Convolution Integrals
An inequality for the th power of the norm of a stochastic convolution
integral in a Hilbert space is proved. The inequality is stronger than
analogues inequalities in the Literature in the sense that it is pathwise and
not in expectation. An application of this inequality is provided for the
semilinear stochastic evolution equations with L\'evy noise and monotone
nonlinear drift. The existence and uniqueness of the mild solutions in
for these equations is proved and a sufficient condition for exponential
asymptotic stability of the solutions is derived
Ferromagnetic ordering of linearly coordinated Co ions in LiSr[CoN]
LiSr[CoN] single crystals were successfully grown out of Li-rich
flux. Temperature- and field-dependent measurements of the magnetization in the
range of K and up to T as well as
measurements of the heat capacity are presented. Ferromagnetic ordering emerges
below K and comparatively large coercivity fields of
T as well as pronounced anisotropy are observed upon cooling. Polycrystalline
samples of the Ca analog LiCa[CoN] were obtained and investigated in a
similar way. In both compounds Co manifests orbital contributions to the
magnetic moment and large single-ion anisotropy that is caused by second-order
Spin-orbit coupling. Quantum chemistry calculations reveal a magnetic
anisotropy energy of 7 meV, twice as large as the values reported for similar
Co systems.Comment: 21 pages, 6 figures, 5 table
Overexpression of MiR-506 in jurkat (Acute T cell leukemia) cell line
Background & Objective: Acute lymphoblastic leukemia (ALL) is a malignant disease that arises from various mutations in B or T-lymphoid progenitors. MicroRNAs (miRNAs) regulate gene expression by binding to the 3' untranslated region of proteincoding genes. Dysregulation of miRNA expression may result in the development of cancerous phenotypes. Therefore, for the first time in this field, the present study aims to investigate the effect of overexpression of miR-506 in Jurkat (acute T cell leukemia) cell line. Methods: In this study, Jurkat cell lines were cultured in RPMI-1640 medium. Next, miR-506 was transfected with concentrations of 50 and 100 nM with Lipofectamine 2000. The accuracy of the transfection was confirmed by the transfection of siRNA conjugated with FITC. 48 h after transfection, the cells were prepared for other tests (flow cytometry, MTT assay, and RNA extraction). The expression level of miR-506 in the cells was analyzed using the quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). Finally, SPSS 21 software was used for the data analysis. Results: According to our results, the viability of cells in concentrations of 50 and 100 nM was significantly higher than the control group. By overexpression of miR-506, the expressions of pro-apoptotic genes (p53, p21) and anti-apoptotic gene B-cell lymphoma-2 (BCL-2) are decreased and increased, respectively. Conclusion: This study showed that miR-506 may function as an oncogenic miRNA in the T-ALL cell line. In conclusion, overexpression of miR-506 leads to an increase in viable cancer cells
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