165 research outputs found
Magnetoconductance anisotropy of a polymer thin film at the onset of metallicity
Thin films of poly(2,5-bis(3-dodecyl-2-yl)-thieno[3,2-b] thiophene) (C12-PBTTT) polymer under electrolyte gating and doping are investigated as model systems for organic thin films devices approaching the metallic side of a metal-insulator (M-I) transition. For the most doped samples, with an estimated density reaching 8 x 10(20) cm(-3) holes and a conductivity exceeding 1000 S cm(-1), a positive high-field magnetoconductance is found in a limited temperature range window and only when the field is perpendicular to the sample plane. This signature of weak localization, combined with indications of finite zero-temperature conductivity, allows us to identify delocalized metallic-like transport in these thin films, even though the conductivity decreases when cooling down the samples
Postnatal Aversive Experience Impairs Sensitivity to Natural Rewards and Increases Susceptibility to Negative Events in Adult Life
Evidence shows that maternal care and postnatal traumatic events
can exert powerful effects on brain circuitry development but little
is known about the impact of early postnatal experiences on processing
of rewarding and aversive stimuli related to the medial prefrontal
cortex (mpFC) function in adult life. In this study, the
unstable maternal environment induced by repeated cross-fostering
(RCF) impaired palatable food conditioned place preference and disrupted
the natural preference for sweetened fluids in the saccharin
preference test. By contrast, RCF increased sensitivity to conditioned
place aversion (CPA) and enhanced immobility in the
forced swimming test. Intracerebral microdialysis data showed that
the RCF prevents mpFC dopamine (DA) outflow regardless of
exposure to rewarding or aversive stimuli, whereas it induces a
strong and sustained prefrontal norepinephrine (NE) release in
response to different aversive experiences. Moreover, the selective
mpFC NE depletion abolished CPA, thus indicating that prefrontal
NE is required for motivational salience attribution to aversionrelated
stimuli. These findings demonstrate that an unstable
maternal environment impairs the natural propensity to seek pleasurable
sources of reward, enhances sensitivity to negative events
in adult life, blunts prefrontal DA outflow, and modulates NE release
in the reverse manner depending on the exposure to rewarding or
aversive stimuli
The non-ergot derived dopamine agonist quinagolide in prevention of early ovarian hyperstimulation syndrome in IVF patients: a randomized, double-blind, placebo-controlled trialâ
Expression of an osmotin-like protein from Solanum nigrum confers drought tolerance in transgenic soybean.
Magnetoconductance anisotropy of a polymer thin film at the onset of metallicity
Thin films of poly(2,5-bis(3-dodecyl-2-yl)-thieno[3,2-b] thiophene) (C12-PBTTT) polymer under electrolyte gating and doping are investigated as model systems for organic thin films devices approaching the metallic side of a metal-insulator (M-I) transition. For the most doped samples, with an estimated density reaching 8 x 10(20) cm(-3) holes and a conductivity exceeding 1000 S cm(-1), a positive high-field magnetoconductance is found in a limited temperature range window and only when the field is perpendicular to the sample plane. This signature of weak localization, combined with indications of finite zero-temperature conductivity, allows us to identify delocalized metallic-like transport in these thin films, even though the conductivity decreases when cooling down the samples. (C) 2015 AIP Publishing LLC
Use of transgenic Aedes aegypti in Brazil: risk perception and assessment.
The OX513A strain of Aedes aegypti, which was developed by the British company Oxitec, expresses a self-limiting transgene that prevents larvae from developing to adulthood. In April 2014, the Brazilian National Technical Commission on Biosafety completed a risk assessment of OX513A and concluded that the strain did not present new biological risks to humans or the environment and could be released in Brazil. At that point, Brazil became the first country to approve the unconstrained release of a genetically modified mosquito. During the assessment, the commission produced a comprehensive list of ? and systematically analysed ? the perceived hazards. Such hazards included the potential survival to adulthood of immature stages carrying the transgene ? should the transgene fail to be expressed or be turned off by exposure to sufficient environmental tetracycline. Other perceived hazards included the potential allergenicity and/or toxicity of the proteins expressed by the gene, the potential for gene flow or increased transmission of human pathogens and the occupation of vacant breeding sites by other vector species. The Zika epidemic both elevated the perceived importance of Ae. aegypti as a vector ? among policy-makers and regulators as well as the general public ? and increased concerns over the release of males of the OX513A strain. We have therefore reassessed the potential hazards. We found that release of the transgenic mosquitoes would still be both safe and of great potential value in the control of diseases spread by Ae. aegypti, such as the chikungunya, dengue and Zika virus disease
Dopamine agonists and ischemic complications in Parkinsonâs disease: a nested caseâcontrol study
Personalised Therapeutic
- âŚ