Análisis de obstáculos en guía de onda rectangular bajo MATLAB para aplicaciones docentes

The aim of this work is to easily facilitate the student the knowledge of the electrical equivalent circuit of the different obstacles used to develop resonators inside a waveguide like: irises, posts, screws, etc. The software presented here OBSTAGUIA has been made under friendly user philosophy and is self-explicative. The able to simulate all types of obstacles, coupled with the graphical and mathematical capacities of MATLAB makes this software an interesting tool easy to use by users at any level. The second objective of this work is the use of the computing routines developed, into more ambitious software capable to design waveguide filters from the user specifications, this software called Wavefil is now under development

PulseSpam: A survey management app

Este Trabajo de Fin de Grado aborda el proceso de desarrollo de una aplicación de escritorio y una aplicación web, que permiten valorar la satisfacción de los miembros de una organización a través de la realización de una pregunta diaria. Las respuestas a dichas preguntas se computan y se muestran a los administradores de la empresa en una aplicación web tipo dashboard, permitiendo controlar los resultados a través de distintas gráficas y filtros, así como realizar la gestión de usuarios y planificación de las preguntas. Este proyecto ha sido desarrollado en base a lo propuesto por el Observatorio Tecnológico de HP SCDS, presentando una versión simplificada de las aplicaciones actualmente disponibles en el mercado pero que contiene las funcionalidades básicas para su utilización. La aplicación web ha sido desarrollada utilizando React y una de sus librerías, Material UI. La API web del servicio RESTful ha sido implementado en ASP.NET Core, permitiendo la conexión con la base de datos no relacional realizada en Mongo DB. La aplicación de escritorio ha sido desarrollada en C# a través de WPF (Windows Presentation Foundation), un estándar para desarrollo de aplicaciones para Windows.This Bachelor’s Thesis describes the development of a desktop application and a web application, meant to allow an organization to check its members’ satisfaction by asking a daily question. Answers to these daily questions are computed and shown to the administrators in a dashboard style web application, showing and filtering the data in different graphics and managing both user management and the questions’ own scheduling. This project has been developed based on HP SCDS Technology Observatory’s proposal for a simplified alternative to already existent applications in the market but retaining all the core features for its basic use. The web application has been developed using React and one of its libraries, Material UI. The web API for the RESTful service has been fully implemented in ASP.NET Core, allowing the connection with a NoSQL database made in MongoDB. The desktop app has been developed in C# using WPF (Windows Presentation Foundation), a standard for Windows based applications.Grado en Ingeniería Informátic

Impact of IPSS-M implementation in real-life clinical practice

ObjectivesThe IPSS-M is a recently published score for risk stratification in myelodysplastic syndromes (MDS), based on clinical and molecular data. We aimed to evaluate its relevance on treatment choice in a real-life setting.MethodsWe retrospectively collected clinical, cytogenetic and molecular data from 166 MDS patients. We calculated IPSS-R and IPSS-M scores and compared Overall Survival (OS) and Leukemia Free Survival (LFS). We also analyzed which patients would have been affected by the re-stratification in terms of clinical management.ResultsWe found that 86.1% of the patients had at least one genetic alteration. The most frequent mutated genes were SF3B1 (25.9%), DNMT3A (16.8%) and ASXL1 (14.4%). IPSS-M re-stratified 48.2% of the patients, of which 16.9% were downgraded and 31.3% were upgraded. IPSS-M improved outcome prediction, with a Harrell’s c-index of 0.680 vs 0.626 for OS and 0.801 vs 0.757 for LFS. In 22.2% of the cohort, the reclassification of the IPSS-M could potentially affect clinical management; 17.4% of the patients would be eligible for treatment intensification and 4.8% for treatment reduction.ConclusionsIPSS-M implementation in clinical practice could imply different treatment approaches in a significant number of patients. Our work validates IPSS-M in an external cohort and confirms its applicability in a real-life setting

Making clinical decisions based on measurable residual disease improves the outcome in multiple myeloma.

The assessment of measurable residual disease (MRD) in bone marrow has proven of prognostic relevance in patients with multiple myeloma (MM). Nevertheless, and unlike other hematologic malignancies, the use of MRD results to make clinical decisions in MM has been underexplored to date. In this retrospective study, we present the results from a multinational and multicenter series of 400 patients with MRD monitoring during front-line therapy with the aim of exploring how clinical decisions made based on those MRD results affected outcomes. As expected, achievement of MRD negativity at any point was associated with improved PFS versus persistent MRD positivity (median PFS 104 vs. 45 months, p < 0.0001). In addition, however, 67 out of 400 patients underwent a clinical decision (treatment discontinuation, intensification or initiation of a new therapy) based on MRD results. Those patients in whom a treatment change was made showed a prolonged PFS in comparison with those 333 patients in which MRD results were not acted upon (respectively, mPFS 104 vs. 62 months, p = 0.005). In patients who achieved MRD negativity during maintenance (n = 186) on at least one occasion, stopping therapy in 24 patients vs. continuing in 162 did not alter PFS (mPFS 120 months vs. 82 months, p = 0.1). Most importantly, however, in patients with a positive MRD during maintenance (n = 214), a clinical decision (either intensification or change of therapy) (n = 43) resulted in better PFS compared to patients in whom no adjustment was made (n = 171) (mPFS NA vs. 39 months, p = 0.02). Interestingly, there were no significant differences when MRD was assessed by flow cytometry or by next-generation sequencing. Herein, we find that MRD is useful in guiding clinical decisions during initial therapy and has a positive impact on PFS in MM patients. This potentially opens a new dimension for the use of MRD in MM, but this role still remains to be confirmed in prospective, randomized clinical trials

Making clinical decisions based on measurable residual disease improves the outcome in multiple myeloma.

The assessment of measurable residual disease (MRD) in bone marrow has proven of prognostic relevance in patients with multiple myeloma (MM). Nevertheless, and unlike other hematologic malignancies, the use of MRD results to make clinical decisions in MM has been underexplored to date. In this retrospective study, we present the results from a multinational and multicenter series of 400 patients with MRD monitoring during front-line therapy with the aim of exploring how clinical decisions made based on those MRD results affected outcomes. As expected, achievement of MRD negativity at any point was associated with improved PFS versus persistent MRD positivity (median PFS 104 vs. 45 months, p < 0.0001). In addition, however, 67 out of 400 patients underwent a clinical decision (treatment discontinuation, intensification or initiation of a new therapy) based on MRD results. Those patients in whom a treatment change was made showed a prolonged PFS in comparison with those 333 patients in which MRD results were not acted upon (respectively, mPFS 104 vs. 62 months, p = 0.005). In patients who achieved MRD negativity during maintenance (n = 186) on at least one occasion, stopping therapy in 24 patients vs. continuing in 162 did not alter PFS (mPFS 120 months vs. 82 months, p = 0.1). Most importantly, however, in patients with a positive MRD during maintenance (n = 214), a clinical decision (either intensification or change of therapy) (n = 43) resulted in better PFS compared to patients in whom no adjustment was made (n = 171) (mPFS NA vs. 39 months, p = 0.02). Interestingly, there were no significant differences when MRD was assessed by flow cytometry or by next-generation sequencing. Herein, we find that MRD is useful in guiding clinical decisions during initial therapy and has a positive impact on PFS in MM patients. This potentially opens a new dimension for the use of MRD in MM, but this role still remains to be confirmed in prospective, randomized clinical trials

Assessment of Mediterranean Aquaculture Sustainability

Aquaculture is a source of food, critical and essential to feed humanity and to ensure the world’s food security, and, also is a business that generates economic interest. This is clearly specified in the analysis document of the State of Fisheries and Aquaculture FAO 2016, which exposes that “aquaculture will become the main driver of change in the fisheries and aquaculture sector“. Aquaculture is the productive industrial activity that will play a crucial role in providing solutions to the millennium challenges. Globally this is the main idea that exists under the MedAID EU Horizon 2020 project. Production and productivity of Mediterranean marine fish aquaculture, mainly seabass and seabream, are stagnating or growing slowly as a result of multiple and interrelated causes. To accomplish the objective of improving its competitiveness and sustainability, MedAID is structured in a first interdisciplinary Work-packages (WPs) to assess technical, environmental, market, socioeconomic and governance weaknesses. WP1, “Holistic sustainability assessment of Mediterranean marine fish farming sector”, aims to carry out this mentioned assessment with a particular focus on the farm’s zootechnical performance, environmental and social sustainability, health, welfare and diseases, economic aspects and governance. The objective is to provide an overview of all the components of the value chain and assist the other WPs in their execution. To succeed in this challenge we started from the knowledge that we get from surveys addressed to the sector. The aim of the present report “Deliverable 1.2. Assessment of Mediterranean Aquaculture Sustainability” is to present the results of such assessment throughout the compilation of different analysis (Zotechnical performance, Environmental and social sustainability, Prevalence of diseases, Economic performance of the industry, and Governance and social acceptability), which has been mainly done based on a survey addressed to Mediterranean aquaculture farms from the whole region. The replies to surveys were compiled in a the Database of Mediterranean aquaculture farms, which have been used to analyse the information from a wider perspective, for both technical and economic indicators considered in the different thematic analysis here presented. MedAID has been able to obtain information from 27 partners and collaborating companies (50 production units) from 10 countries. For confidentially reasons their names are no mentioned in this report. Our most sincere gratitude is due to them, as without their collaboration, this study would had not been possible. Although not all companies replied to all questions, and for some parts of the analysis the data were small, this study was able to identify significant associations between key Performance Indicators (KPIs) and predictor variables in the units that took part in the survey. The survey data analysis shows that farming practices differ among the farms, allowing for improvement of management and, also, there is not a common production method for the Mediterranean seabass and seabream production. Moreover, it should be considered both seabass and seabream routinely surveyed and analysed separately, and the possibility of analysing separately the farms according production systems. Companies need to improve their productive efficiency through technical, operational and management innovations with a real transfer to the productive activity. The reduction of the average cost of production is a key aspect for the sustainability of the activity. While diversification is more efficient as the size of the company increases. Finally, there is a broad consensus about the necessity of improving governance, reducing the complexity of the administration and the regulation of the sector. It is also argued the need to reduce the time required to obtain a license

Chasing Gravitational Waves with the Chereknov Telescope Array

Presented at the 38th International Cosmic Ray Conference (ICRC 2023), 2023 (arXiv:2309.08219)2310.07413International audienceThe detection of gravitational waves from a binary neutron star merger by Advanced LIGO and Advanced Virgo (GW170817), along with the discovery of the electromagnetic counterparts of this gravitational wave event, ushered in a new era of multimessenger astronomy, providing the first direct evidence that BNS mergers are progenitors of short gamma-ray bursts (GRBs). Such events may also produce very-high-energy (VHE, > 100GeV) photons which have yet to be detected in coincidence with a gravitational wave signal. The Cherenkov Telescope Array (CTA) is a next-generation VHE observatory which aims to be indispensable in this search, with an unparalleled sensitivity and ability to slew anywhere on the sky within a few tens of seconds. New observing modes and follow-up strategies are being developed for CTA to rapidly cover localization areas of gravitational wave events that are typically larger than the CTA field of view. This work will evaluate and provide estimations on the expected number of of gravitational wave events that will be observable with CTA, considering both on- and off-axis emission. In addition, we will present and discuss the prospects of potential follow-up strategies with CTA