Hydrogen Deep Ocean Link: a global sustainable interconnected energy grid

The world is undergoing a substantial energy transition with an increasing share of intermittent sources of energy on the grid, which is increasing the challenges to operate the power grid reliably. An option that has been receiving much focus after the COVID pandemic is the development of a hydrogen economy. Challenges for a hydrogen economy are the high investment costs involved in compression, storage, and long-distance transportation. This paper analyses an innovative proposal for the creation of hydrogen ocean links. It intends to fill existing gaps in the creation of a hydrogen economy with the increase in flexibility and viability for hydrogen production, consumption, compression, storage, and transportation. The main concept behind the proposals presented in this paper consists of using the fact that the pressure in the deep sea is very high, which allows a thin and cheap HDPE tank to store and transport large amounts of pressurized hydrogen in the deep sea. This is performed by replacing seawater with pressurized hydrogen and maintaining the pressure in the pipes similar to the outside pressure. Hydrogen Deep Ocean Link has the potential of increasing the interconnectivity of different regional energy grids into a global sustainable interconnected energy system

Temporal trends in the incidence, treatment patterns, and outcomes of coronary artery disease and peripheral artery disease in the UK, 2006–2015

Aims Most reports estimating national incidence rates of coronary (CAD) and peripheral arterial disease (PAD) have focused on stable outpatients or acute or elective hospital admissions, but not on the overall burden of disease. In this study, we report the changing trends in the population-level incidence of CAD and PAD, respectively from 2006 to 2015, statin utilization for secondary prevention and survival outcomes using multiple nationally representative data sources from the UK (primary care encounters, hospital admissions, and procedure-level data). Methods and results A nationally representative study of linked primary and secondary care electronic health records of 4.6 million individuals from the UK. We calculated crude and standardized annual incidence rates separately for CAD and PAD. Statin use for secondary prevention, trends in annual major vascular event rates, and mortality between 2006 and 2015, were estimated for CAD and PAD, respectively. We identified 160 376 and 70 753 patients with incident CAD and PAD, respectively. The age- and sex-standardized incidence of CAD was similar in 2006 (443 per 100 000 person-years) and 2015 [436 per 100 000 person-years; adjusted incidence rate ratio (IRR) 0.98, 95% confidence interval (CI) 0.96–1.00]. In contrast, there was a 15% decline in the standardized incidence of PAD (236 per 100 000 person-years in 2006 to 202 per 100 000 person-years in 2015; adjusted IRR 0.85, 95% CI 0.82–0.88). The proportion of incident CAD and PAD patients prescribed long-term statins, was only 66% and 55%, respectively and was less common amongst women, patients aged >70 years, with heart failure, chronic lung disease, or depression. Cardiovascular mortality declined by 43% for incident CAD (adjusted IRR 0.57, 95% CI 0.50–0.64) between 2006 and 2015 but did not decline for incident PAD (adjusted IRR 0.84, 95% CI 0.70–1.00). Conclusion and relevance In the UK, the standardized incidence of CAD appears stable but mortality rates are falling, whereas the standardized incidence of PAD is falling but mortality rates are not

Existing and new arrangements of pumped-hydro storage plants

The energy sector is undergoing substantial transition with the integration of variable renewable energy sources, such as wind and solar energy. These sources come with hourly, daily, seasonal and yearly variations; raising the need for short and long-term energy storage technologies to guarantee the smooth and secure supply of electricity. This paper critically reviews the existing types of pumped-hydro storage plants, highlighting the advantages and disadvantages of each configuration. We propose some innovative arrangements for pumped-hydro storage, which increases the possibility to find suitable locations for building large-scale reservoirs for long-term energy and water storage. Some of the proposed arrangements are compared in a case study for the upper Zambezi water basin, which has considerable water storage limitations due to its flat topography and arid climate. Results demonstrate that the proposed combined short and long-term cycles pumped-storage arrangement could be a viable solution for energy storage and reduce the cost for water storage to near zero

Seawater air-conditioning and ammonia district cooling: A solution for warm coastal regions

The world switching to more sustainable energy sources to curb CO2 emissions and haul climate change. One sector expected to see rapid growth in energy consumption is the cooling sector due to population growth and climate change. A sustainable solution for cooling needs in coastal areas that are not often addressed is seawater air-conditioning, which pumps cold water from the deep sea to the shore and uses it for cooling. The main challenge for this technology is to distribute the cooling service. This paper proposes using pressurized ammonia to distribute the cooling services provided by SWAC plants. Results show that ammonia district cooling allows SWAC to significantly increase its load demand and lower cooling costs. Ammonia district cooling could be the missing piece for implementing seawater air-conditioning due to its potential to increase the cooling load of district cooling systems

Derailment risk and dynamics of railway vehicles in curved tracks: Analysis of the effect of failed fasteners

[EN] The effect of the fastener s failure in a railway track on the dynamic forces produced in the wheel-rail contact is studied using the simulation software VAMPIRE to assess the derailment risk of two different vehicles in two curves with distinct characteristics. First, a 3D-FEM model of a real track is constructed, paying special attention to fasteners, and calibrated with displacement data obtained experimentally during a train passage. This numerical model is subsequently used to determine the track vertical and lateral stiffness. This study evidences that although the track can practically lose its lateral stiffness as a consequence of the failure of 7 consecutive fasteners, the vehicle stability would not be necessarily compromised in the flawed zone. Moreover, the results reveal that the uncompensated acceleration and the distance along which the fasteners are failed play an important role in the dynamic behavior of the vehicle-track system, influencing strongly the risk of derailmentMorales-Ivorra, S.; Real Herráiz, JI.; Hernández Gracia, C.; Montalbán-Domingo, L. (2016). Derailment risk and dynamics of railway vehicles in curved tracks: Analysis of the effect of failed fasteners. Journal of Modern Transportation. 24(1):38-47. doi:10.1007/s40534-015-0093-zS3847241Iwnicki S (2006) Handbook of railway vehicle dynamics.CRC Press, Boca RatónJin XS, Wen ZF, Wang KY, Zhou ZR, Liu QY, Li CH (2006) Three-dimensional train-track model for study of rail corrugation. J Sound Vib 293:830–855Jin X, Wen Z, Xiao X (2007) A numerical method for prediction of curved rail wear. Multibody Sys Dyn 18:531–557Li W, Xiao G, Wen Z, Xiao X, Jin X (2011) Plastic deformation of curved rail at rail weld caused by train-track dynamic interaction. Wear 271:311–318Jin X, Wen Z (2008) Effect of discrete track support by sleepers on rail corrugation at a curved track. J Sound Vib 315:279–300Di Gialleonardo E, Bruni S, True H (2014) Analysis of the nonlinear dynamics of a 2-axle freight wagon in curves. Veh Syst Dyn 52(1):125–141Wang K, Liu P (2012) Lateral stability analysis of heavy-haul vehicle on curved track based on wheel/rail coupled dynamics. J Transp Technol 2:150–157Kurzeck B, Hecht M (2010) Dynamic simulation of friction-induced vibrations in a light railway bogie while curving compared with measurement results. Veh Syst Dyn 48:121–138Chen P, Gao L, Hao J (2007) Simulation study on parameters influencing wheel/rail wear in railway curve. China Railway Science 5Sun Y, Cole C, Boyd P (2011) A numerical method using VAMPIRE modelling for prediction of turnout curve wheel-rail wear. Wear 271(1–2):482–491Brabie D (2007) On derailment-worthiness in railway vehicle design. Analysis of vehicle features influencing derailment processes and consequences, PhD Thesis, Royal Institute of Technology, StockholmMatsumoto A, Sato Y, Ohno H, Shimizu M, Kurihara J, Saitou T, Michitsuji Y, Matsui R, Tanimoto M, Mizuno M (2014) Actual states of wheel/rail contact forces and friction on sharp curves—continuous monitoring from in-service trains and numerical simulations. Wear 314:189–197Wang L, Huang A, Liu G (2013) Analysis on curve negotiation ability of the rail vehicle based on SIMPACK. Adv Mater Res 721:551–555Eom BG, Lee H (2010) Assessment of running safety of railway vehicles using multibody dynamics. Int J Precis Eng Manuf 11(2):315–320Zhou L, Shen Z (2013) Dynamic analysis of a high-speed train operating on a curved track with failed fasteners. J Zhejiang Univ Sci A 14(6):447–458Xiao X, Jin X, Wen Z (2007) Effect of disabled fastening systems and ballast on vehicle derailment. J Vib Acoust 129:217–229Shi W, Cai C (2011) Influence of slab track fastener failure on track dynamic performance. In: Advances in environmental vibration-proceedings of the 5th international symposium on environmental vibration, Chengdu, pp 686–692Xiao X, Jin X, Deng Y, Zhou Z (2008) Effect of curved track support failure on vehicle derailment. Veh Syst Dyn 46(11):1029–1059Zakeri J, Fakhari M, Mirfattahi B (2012) Lateral resistance of railway track with frictional sleepers. Proc Inst Civ Eng Transp 165(2):151–155Gibert X, Patel V, Chellappa R (2015) Robust fastener detection for autonomous visual railway track inspection. In: IEEE Winter Conference on Applications of Computer Vision, Waikoloa Beach Hawai, pp 694–701Thompson D, Hemsworth B, Vincent N (1996) Experimental validation of the TWINS prediction program for rolling noise, part 1: description of the model and method. J Sound Vib 193(1):123–135Zakeri JA (2012) Lateral resistance of railway track. In: Perpinya DX (ed) Reliability and safety in railway. InTech Europe, Rijeka, pp 357–374Kernes RG, Edwards JR, Dersh MS, Lange DA, Barkan CP (2011) Investigation of the dynamic frictional properties of a concrete crosstie rail seat and pad and its effect on rail seat deterioration (RSD). Transportation Research Board 91st annual meeting. Railtec, Chicago, IllinoisCarrascal-Vaquero I (2006) Optimization and analysis of the behavior of fastener systems for Spanish high-speed railways. PhD Thesis, University of Cantabria, Santander (In Spanish)Sany J (1996) Another look at the single wheel derailment criteria. In: Proceedings of the IEEE/ASME Joint Railroad Conference, pp 17–22Koo J, Oh H (2014) A new derailment coefficient considering dynamic and geometrical effects of a single wheelset. J Mech Sci Technol 28(9):3483–3498UIC-Leaflet-518 (2009) Testing and approval of railway vehicles from the point of view of their dynamic behaviour-safety-track fatigue-ride quality. Railway Technical Publications, ParisUNE-EN14363:2007 (2007) Railway applications—testing for the acceptance of running characteristics of railway vehicles—testing of running behaviour and stationary tests. AENOR, Madri

Safety assessment of underground vehicles passing over highly resilient curved tracks in the presence of a broken rail

Vehicle–track interaction for a new resilient slab track designed to reduce noise and vibration levels was analysed, in order to assess the derailment risk on a curved track when encountering a broken rail. Sensitivity of the rail support spacing of the relative position of the rail breakage between two adjacent rail supports and of running speed were analysed for two different elasticities of the rail fastening system. In none of the cases analysed was observed an appreciable difference between either of the elastic systems. As was expected, the most unfavourable situations were those with greater rail support spacing and those with greater distance from the breakage to the nearest rail support, although in none of the simulations performed did a derailment occur when running over the broken rail. When varying the running speed, the most favourable condition was obtained for an intermediate speed, due to the superposition of two antagonistic effects

Use of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken

Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear. Herein, study reports role of quercetin in modulation of P-gp expression and subsequent effects on the pharmacokinetics of enrofloxacin in broilers. Results show that P-gp expression was increased in a dose-dependent manner following exposure to quercetin in Caco-2 cells and tissues of chicken. Absorption rate constant and apparent permeability coefficient of rhodamine 123 were decreased, reflecting efflux function of P-gp in chicken intestine increased by quercetin. Quercetin altered pharmacokinetic of enrofloxacin by decreasing area under curve, peak concentration, and time to reach peak concentration and by increasing clearance rate. Molecular docking shows quercetin can form favorable interactions with binding pocket of chicken xenobiotic receptor (CXR). Results provide convincing evidence that quercetin induced P-gp expression in tissues by possible interaction with CXR, and consequently reducing bioavailability of orally administered enrofloxacin through restricting its intestinal absorption and liver/kidney clearance in broilers. The results can be further extended to guide reasonable use of quercetin to avoid drug-feed interaction occurred with co-administered enrofloxacin or other similar antimicrobials.Peer reviewedFinal Published versio

Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation

Avirus that reproduces in a host without killing cells can easily establish a successful infection. Previously, we showed that dengue-2, a virus that threatens 40% of the world, induces autophagy, enabling dengue to reproduce in cells without triggering cell death. Autophagy further protects the virus-laden cells from further insults. In this study, we evaluate how it does so; we show that dengue upregulates host pathways that increase autophagy, namely endoplasmic reticulum (ER) stress and ataxia telangiectasiamutated (ATM) signaling followed by production of reactive oxygen species (ROS). Inhibition of ER stress or ATM signaling abrogates the dengueconferred protection against other cell stressors. Direct inhibition of ER stress response in infected cells decreases autophagosome turnover, reduces ROS production and limits reproduction of dengue virus. Blocking ATM activation, which is an early response to infection, decreases transcription of ER stress response proteins, but ATM has limited impact on production of ROS and virus titers. Production of ROS determines only late-onset autophagy in infected cells and is not necessary for dengue-induced protection from stressors. Collectively, these results demonstrate that among the multiple autophagy-inducing pathways during infection, ER stress signaling is more important to viral replication and protection of cells than either ATM or ROS-mediated signaling. To limit virus production and survival of dengue-infected cells, one must address the earliest phase of autophagy, induced by ER stress

Mountain Gravity Energy Storage: A new solution for closing the gap between existing short- and long-term storage technologies

The world is undergoing an energy transition with the inclusion of intermittent sources of energy in the grid. These variable renewable energy sources require energy storage solutions to be integrated smoothly over different time steps. In the near future, batteries can provide short-term storage solutions and pumped-hydro storage can provide long-term energy storage with large generation capacities. However, none of these technologies can provide long-term energy storage in grids with small demand. This paper proposes a new storage concept called Mountain Gravity Energy Storage (MGES) that could fill this gap in storage services. MGES systems move sand or gravel from a lower storage site to an upper elevation. The higher the height difference the greater the amount of stored energy in a given installed capacity, as this technology is constrained to the topography of the location. MGES cost varies from 50 to 100 $/MWh of stored energy and 1–2 M$/MW of installed capacity. MGES could be a feasible option for micro-grids, for example, small islands and isolated areas, and power systems where electricity costs are high, demand for energy storage is smaller than 20 MW with monthly or seasonal storage requirements

Surgical experience and identification of errors in laparoscopic cholecystectomy.

BACKGROUND: Surgical errors are acts or omissions resulting in negative consequences and/or increased operating time. This study describes surgeon-reported errors in laparoscopic cholecystectomy. METHODS: Intraoperative videos were uploaded and annotated on Touch SurgeryTM Enterprise. Participants evaluated videos for severity using a 10-point intraoperative cholecystitis grading score, and errors using Observational Clinical Human Reliability Assessment, which includes skill, consequence, and mechanism classifications. RESULTS: Nine videos were assessed by 8 participants (3 junior (specialist trainee (ST) 3-5), 2 senior trainees (ST6-8), and 3 consultants). Participants identified 550 errors. Positive relationships were seen between total operating time and error count (r2 = 0.284, P < 0.001), intraoperative grade score and error count (r2 = 0.578, P = 0.001), and intraoperative grade score and total operating time (r2 = 0.157, P < 0.001). Error counts differed significantly across intraoperative phases (H(6) = 47.06, P < 0.001), most frequently at dissection of the hepatocystic triangle (total 282; median 33.5 (i.q.r. 23.5-47.8, range 15-63)), ligation/division of cystic structures (total 124; median 13.5 (i.q.r. 12-19.3, range 10-26)), and gallbladder dissection (total 117; median 14.5 (i.q.r. 10.3-18.8, range 6-26)). There were no significant differences in error counts between juniors, seniors, and consultants (H(2) = 0.03, P = 0.987). Errors were classified differently. For dissection of the hepatocystic triangle, thermal injuries (50 in total) were frequently classified as executional, consequential errors; trainees classified thermal injuries as step done with excessive force, speed, depth, distance, time or rotation (29 out of 50), whereas consultants classified them as incorrect orientation (6 out of 50). For ligation/division of cystic structures, inappropriate clipping (60 errors in total), procedural errors were reported by junior trainees (6 out of 60), but not consultants. For gallbladder dissection, inappropriate dissection (20 errors in total) was reported in incorrect planes by consultants and seniors (6 out of 20), but not by juniors. Poor economy of movement (11 errors in total) was reported more by consultants (8 out of 11) than trainees (3 out of 11). CONCLUSION: This study suggests that surgical experience influences error interpretation, but the benefits for surgical training are currently unclear