Shielding features of concrete types containing sepiolite mineral: comprehensive study on experimental, XCOM and MCNPX results

Natural sepiolite mineral is a naturally occurring clay form belonging to a part of layered silicate. Because of its advantages such as low production cost, light-weight and convenient, it may be selected as an alternative shielding material to others. Radiation shielding performances of some concretes to sepiolite and B4C addictive have been researched reported in a wide energy region of 0.08–1.333 MeV using experimental data, MCNP and XCOM. The simulated data obtained by MCNPX are discussed and compared with the experimental results as well as with the XCOM results. The simulations match the experiments very well except for S3 sample. From the measurement, the maximum gamma-ray attenuation was detected in the concrete specimen with 10% sepiolite (S1) while the minimum attenuation of gamma-ray was noted in the concrete specimen with 30% sepiolite (S3). The addition of sepiolite mineral to concretes may be an alternative option that can be used in several radiation protection applications

Improving Domestic Ergonomics: A Fuzzy-Based Model Approach

In this study a fuzzy logic model was adopted to assess the degree of Domestic Ergonomic Hazards (DEH) among women in the Southwest Nigeria. Three risk factors of weight (Kg), height of load (cm) and the handlers’ arm reach (cm) were used. The leading objective was to provide an improved assessment ergonomics tool to Risk Assessment Filter (RAF). The algorithm of the fuzzy inference engine applied sets of 64 linguistic rules to generate the output variable in lifting/lowering risk. The Spearman’s rank correlation value of 0.85 at the confidence level of 0.01, indicated no significant difference between the human predictions of DEH with the use of RAF tool and the model’s predictions. The risk values and interpretations generated by the model were confirmed not just similar to, but with better information than, using RAF. The study proposed a fuzzy-based model for an enhanced domestic ergonomics among women than using RAF device. It is simple and can find its usefulness in household chores

Camel Milk Triggers Apoptotic Signaling Pathways in Human Hepatoma HepG2 and Breast Cancer MCF7 Cell Lines through Transcriptional Mechanism

Few published studies have reported the use of crude camel milk in the treatment of stomach infections, tuberculosis and cancer. Yet, little research was conducted on the effect of camel milk on the apoptosis and oxidative stress associated with human cancer. The present study investigated the effect and the underlying mechanisms of camel milk on the proliferation of human cancer cells using an in vitro model of human hepatoma (HepG2) and human breast (MCF7) cancer cells. Our results showed that camel milk, but not bovine milk, significantly inhibited HepG2 and MCF7 cells proliferation through the activation of caspase-3 mRNA and activity levels, and the induction of death receptors in both cell lines. In addition, Camel milk enhanced the expression of oxidative stress markers, heme oxygenase-1 and reactive oxygen species production in both cells. Mechanistically, the increase in caspase-3 mRNA levels by camel milk was completely blocked by the transcriptional inhibitor, actinomycin D; implying that camel milk increased de novo RNA synthesis. Furthermore, Inhibition of the mitogen activated protein kinases differentially modulated the camel milk-induced caspase-3 mRNA levels. Taken together, camel milk inhibited HepG2 and MCF7 cells survival and proliferation through the activation of both the extrinsic and intrinsic apoptotic pathways

Development of in vitro propagation system for Atriplex halimus L.

Explants excised from adult shrubs were surface sterilized and cultured on Murashige and Skoog (MS) basal medium in thepresence of plant growth regulators (PGRs) at different concentrations. A high multiplication rate of 7.2-fold was achieved every four weekson MS medium supplemented with 4.44 μM BA, 0.49 μM IBA and 0.58 μM GA3. Rooting was achieved with 73% efficiency within 2-4 weekson agar-gelled MS basal medium free of PGRs. Rooted plantlets were gradually acclimatized to field conditions over 5-6 weeks with 65%efficiency. For in vitro selection for salt tolerance, MS medium was supplemented with increasing concentrations of NaCl ranging between25 and 1000 mM. This study has demonstrated that in vitro shoots could tolerate up to 600 mM NaCl with optimal growth at 200 mM, whilehigher concentrations of NaCl affected growth negatively. Growth and shoot number decreased with increasing NaCl concentration with allplantlets died at 1000 mM NaCl

A comprehensive study of the energy absorption and exposure buildup factors of different bricks for gamma-rays shielding

The present investigation has been performed on different bricks for the purpose of gamma-ray shielding. The values of the mass attenuation coefficient (µ/ρ), energy absorption buildup factor (EABF) and exposure buildup factor (EBF) were determined and utilized to assess the shielding effectiveness of the bricks under investigation. The mass attenuation coefficients of the selected bricks were calculated theoretically using WinXcom program and compared with MCNPX code. Good agreement between WinXcom and MCNPX results was observed. Furthermore, the EABF and EBF have been discussed as functions of the incident photon energy and penetration depth. It has been found that the EABF and EBF values are very large in the intermediate energy region. The steel slag showed good shielding properties, consequently, this brick is eco-friendly and feasible compared with other types of bricks used for construction. The results in this work should be useful in the construction of effectual shielding against hazardous gamma-rays

A holistic and proactive approach to forecasting cyber threats

Traditionally, cyber-attack detection relies on reactive, assistive techniques, where pattern-matching algorithms help human experts to scan system logs and network traffic for known virus or malware signatures. Recent research has introduced effective Machine Learning (ML) models for cyber-attack detection, promising to automate the task of detecting, tracking and blocking malware and intruders. Much less effort has been devoted to cyber-attack prediction, especially beyond the short-term time scale of hours and days. Approaches that can forecast attacks likely to happen in the longer term are desirable, as this gives defenders more time to develop and share defensive actions and tools. Today, long-term predictions of attack waves are mostly based on the subjective perceptiveness of experienced human experts, which can be impaired by the scarcity of cyber-security expertise. This paper introduces a novel ML-based approach that leverages unstructured big data and logs to forecast the trend of cyber-attacks at a large scale, years in advance. To this end, we put forward a framework that utilises a monthly dataset of major cyber incidents in 36 countries over the past 11 years, with new features extracted from three major categories of big data sources, namely the scientific research literature, news, blogs, and tweets. Our framework not only identifies future attack trends in an automated fashion, but also generates a threat cycle that drills down into five key phases that constitute the life cycle of all 42 known cyber threats

DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways

This work is licensed under a Creative Commons Attribution 4.0 International License.Doxorubicin (DOX) is a very potent and effective anticancer agent. However, the effectiveness of DOX in osteosarcoma is usually limited by the acquired drug resistance. Recently, Vitamin D (Vit-D) was shown to suppress the growth of many human cancer cells. Taken together, we synthesized DOX-Vit D by conjugating Vit-D to DOX in order to increase the delivery of DOX into cancer cells and mitigate the chemoresistance associated with DOX. For this purpose, MG63 cells were treated with 10 µM DOX or DOX-Vit D for 24 h. Thereafter, MTT, real-time PCR and western blot analysis were used to determine cell proliferation, genes and proteins expression, respectively. Our results showed that DOX-Vit D, but not DOX, significantly elicited an apoptotic signal in MG63 cells as evidenced by induction of death receptor, Caspase-3 and BCLxs genes. Mechanistically, the DOX-Vit D-induced apoptogens were credited to the activation of p-JNK and p-p38 signaling pathway and the inhibition of proliferative proteins, p-Akt and p-mTOR. Our findings propose that DOX-Vit D suppressed the growth of MG63 cells by inducing apoptosis while inhibiting cell survival and proliferative signaling pathways. DOX-Vit D may serve as a novel drug delivery approach to potentiate the delivery of DOX into cancer cells.Canadian Institutes of Health Research [Grant 106665]U.S. National Cancer Institute [Grant R01CA173292