SOSIALISASI TATA CARA PENDAFTARAN TANAH WAKAF DI MUI KABUPATEN SIMALUNGUN

Waqf institutions are one of the Islamic social institutions that have high socio-economic value, and are a form of embodiment of social justice in Islam. in general, so it is necessary to develop its utilization in accordance with sharia principles, as mentioned in the Al-Qur'an surah At-Taubah verse 103. However, in reality many waqf lands are neglected in the community, giving rise to legal problems, especially in Simalungun Regency. This is due to Nazhir's inability to manage and develop waqf assets, the attitude of the people who do not care, the community does not understand the status of waqf assets that should be protected, and the community does not understand how to register waqf land. This problem encourages extension agents to cooperate with Ladui MUI Province, MUI Simalungun Regency, to conduct legal counseling entitled Procedures for Registration of Waqf Land in the form of Community Service at the Simalungun Regency MUI Office. Ways and conditions for registering waqf land, understanding the elements of waqf, nazhir waqf obligations, understanding legal issues regarding waqf and the legal force of waqf certificates.  The conclusion in this activity is that it is necessary to increase the frequency and socialization regarding. Procedures for Waqf Land Registration

Novel Mechanisms Underlying Diabetes-Induced Atrial Fibrillation

Diabetes results from a defect in insulin production (type-1) or action (type-2) causing dysfunctional glucose uptake. Diabetic patients are predisposed to cardiac complications such as atrial fibrillation (AF). The heart is a major organ to utilize glucose; however, little is known about atrial glucose metabolism. Glucose transport into the cell via Glucose Transporters (GLUTs) is the rate-limiting step of glucose utilization. Although GLUT4 is the major cardiac isoform, GLUT8 has emerged as a novel isoform. Atrial structural remodeling and advanced glycation end products (AGEs) have been suggested as precursors to AF. However, glucose and insulin disturbances during diabetes may directly affect atrial function, potentially leading to AF. We hypothesize that the dysregulation of glucose metabolism in the diabetic atria underlies diabetes-induced AF. The specific aims of this dissertation are to test the hypothesis that: 1) GLUT-4 and -8 translocation to the atrial cell surface is insulin regulated and is impaired during insulin-dependent diabetes; 2) GLUT-4 and -8 translocation will be impaired during insulin-resistance-induced AF; and 3) impaired glucose metabolism resulting from insulin dysregulation provides a metabolic substrate for the development of AF. GLUT protein expression was measured in atrial myocytes of healthy rats, in the atrial tissue of insulin-deficient (streptozotocin-induced) and insulin-resistant (high-fat-diet-induced) mice. Active cell surface GLUT content was measured using the biotinylated photolabeled assay in the perfused heart. AF was induced by transesophageal atrial pacing. Atrial fibrosis and AGE were measured using histological analysis. We reported that both GLUT4 and GLUT8 are insulin sensitive in the healthy atria and are regulated by the insulin signaling pathway (i.e., Akt/AS160). Our data demonstrated that GLUT translocation is downregulated in the atria during insulin dysregulation. In addition, insulin treatment rescued GLUT translocation to the atrial cell surface during insulin deficiency but not during insulin resistance. We reported the absence of atrial fibrosis and AGE accumulation in animals with insulin dysregulation. Our results also indicated that insulin dysregulation significantly increases the vulnerability to AF. Overall, the results suggest that in the absence of atrial structural remodeling, insulin dysregulation may induce perturbations in energy production which could underlie the development of diabetes-induced AF.Mechanical and Aerospace Engineerin

Development of Loop-Mediated Isothermal Amplification Assay for Rapid Detection and Analysis of the Root-Knot Nematode Meloidogyne hapla in Soil

Soil analysis is crucial for estimating the risk of crop damage by the root-knot nematode Meloidogyne hapla. Here, we developed an analysis assay based on Loop-mediated Isothermal Amplification (LAMP). The LAMP primers were verified for specificity against 10 different nematode species. A manual soil DNA extraction, referred to as SKMM, was developed and compared with a FastDNA kit followed by DNA purification. DNA was extracted with both methods from artificially inoculated soils as well as from naturally infested soil collected from farm fields. The primers exclusively amplified DNA from M. hapla with both colorimetric and real-time LAMP. The detection limit was 193 gene copies and 0.0016 juveniles (12 pg mu L-1) per reaction. DNA concentrations and purity (A(260)/A(230)) were significantly higher using the SKMM procedure compared with the kit. From the field samples collected in 2019, DNA was amplified from 16% of samples extracted with SKMM and from 11% of samples using the kit. Occurrence of M. hapla DNA was confirmed in soil samples from two out of six field soils in 2020 using both real-time LAMP and qPCR. In conclusion, the developed real-time LAMP is a fast and specific assay for detection and quantification of M. hapla DNA in soil

Assessment of cost optimal solutions for high performance multi-family buildings in Iran

According to the international benchmarks proposed for the energy demand reduction, the Iranian government, for limiting domestic energy demand growth, has set some energy efficiency policies. In this regard, the present study proposes various solutions to investigate the feasibility of improving the performance of an existing typical multi-family building in Iranian context, to achieve a high performance one with proper cost-optimal levels of energy performance by using the global cost approach defined by EU legislation. Precisely 50 different packages of energy efficiency measures were analyzed in terms of economic and energy performance with consideration on the effects of different envelope thermal insulation, shading system, window types and highly efficient systems in addition to the solar renewable energy source. Then the impact of the selected measures on energy efficiency improvement and global cost were studied and revealed that obtaining high performance building simultaneously with the cost optimal levels can be fulfilled, just when the financial support from the government subsidies exist, otherwise there is still a long way from being economically feasible

Effect of Glycated Albumin and Shear Stress on Endothelial Cell Functions

Our goal was to evaluate the combined effect of albumin glycation extent and physiological shear loading on endothelial cell (EC) functions. Cultured ECs were incubated with glycated or non-glycated albumin (2, 6 or 8 weeks of glycation) for up to 5 days. After incubation, ECs were subjected to low, medium or high shear stress (4, 10, 40 dynes/cm2) for 1 hour. EC morphology, shear induced cytoskeletal structure and inflammatory and thrombogenic responses were observed. We hypothesized that the combined effect of high shear stress with glycated albumin would enhance endothelial inflammatory responses to mimic cardiovascular diseases. Results indicated that ECs incubated with advanced (6 and 8 weeks) glycated albumin and exposed to high shear stress had an altered actin alignment and structure. Furthermore, EC metabolic activity in the presence of glycated albumin, decreased with increasing shear stress. Also, ECs treated with glycated albumin induced new communicative network formation. Thus, the results indicate that the presence of advance glycation end products severely affects the function of ECs under various physiological shear stress conditions.Mechanical & Aerospace Engineerin

Optimal control problems for path planing of AUV using simplified models

Here we propose a simplified model for the path planning of an Autonomous Underwater Vehicle (AUV) in an horizontal plane when ocean currents are considered. The model includes kinematic equations and a simple dynamic equation. Our problem of interest is a minimum time problem with state constraints where the control appears linearly. This problem is solved numerically using the direct method. We extract various tests from the Maximum Principle that are then used to validate the numerical solution. In contrast to many other literature we apply the Maximum Principle as defined in [9]

Conceptualizing environmental effects of carsharing services: A system thinking approach

Emerging carsharing services and their interconnections with other modes of urban transport, regulations, car manufacturing and population have affected the dynamics of energy consumption, environmental pollution and greenhouse gas emission within a complex system. However, although some aspects of environmental impacts of transport sector have been investigated in the literature, well-deserved studies on the environmental effects of carsharing services following a system thinking approach is missing. This research aims at providing a comprehensive conceptual framework to systematize the interconnections between carsharing services and their environmental effects. To do this, system dynamics (SD) modeling, as a tool to simulate complex and dynamic systems, is applied and the proposed framework model is illustrated by using a causal-loop diagram (CLD). Along with analyzing the main identified causal loops within the presented CLD, relevant strategies are proposed to reduce the negative environmental effects associated with the carsharing services, considering the whole lifecycle of a shared vehicle. The proposed framework can help environment policy makers and shared mobility practitioners in long-term strategic decision-making. Moreover, it can be applied by the researchers as a basis for future research, not only for SD modeling but also other simulation and analysis structures

Mesoporous Activated Carbon Supported Ru Catalysts to Efficiently Convert Cellulose into Sorbitol by Hydrolytic Hydrogenation

Catalysts consisting of Ru nanoparticles (1 wt%), supported on mesoporous activated carbons (ACs), were prepared and used in the one-pot hydrolytic hydrogenation of cellulose to obtain sorbitol. The carbon materials used as supports are a pristine commercial mesoporous AC (named SA), and two samples derived from it by sulfonation or oxidation treatments (named SASu and SAS, respectively). The catalysts have been thoroughly characterized regarding both surface chemistry and porosity, as well as Ru electronic state and particle size. The amount and type of surface functional groups in the carbon materials becomes modified as a result of the Ru incorporation process, while a high mesopore volume is preserved upon functionalization and Ru incorporation. The prepared catalysts have shown to be very active, with cellulose conversion close to 50% and selectivity to sorbitol above 75%. The support functionalization does not lead to an improvement of the catalysts’ behavior and, in fact, the Ru/SA catalyst is the most effective one, with about 50% yield to sorbitol, and a very low generation of by-products.This research was funded by Spanish Ministry of Science, Innovation and Universities and FEDER, project of reference RTI2018-095291-B-I00, GV/FEDER (PROMETEO/2018/076) and University of Alicante (VIGROB-136)