49 research outputs found
Neuronal and psychological underpinnings of pathological gambling
Like in the case of drugs, gambling hijacks reward circuits in a brain which is not prepared to receive such intense stimulation. Dopamine is normally released in response to reward and uncertainty in order to allow animals to stay alive in their environment – where rewards are relatively unpredictable. In this case, behavior is regulated by environmental feedbacks, leading animals to persevere or to give up. In contrast, drugs provide a direct, intense pharmacological stimulation of the dopamine system that operates independently of environmental feedbacks, and hence causes “motivational runaways”. With respect to gambling, the confined environment experienced by gamblers favors the emergence of excitatory conditioned cues, so that positive feedbacks take over negative feedbacks. Although drugs and gambling may act differently, their abnormal activation of reward circuitry generates an underestimation of negative consequences and promotes the development of addictive/compulsive behavior. In Parkinson’s and Huntington’s disease, dopamine-related therapies may disrupt these feedbacks on dopamine signalling, potentially leading to various addictions, including pathological gambling. The goal of this Research Topic is to further our understanding of the neurobiological mechanisms underlying the development of pathological gambling. This eBook contains a cross-disciplinary collection of research and review articles, ranging in scope from animal behavioral models to human imaging studies
Reversing the Downward Trend: Innovative Approaches to IS/IT Course Development and Delivery
It is well known that student enrollment, and quite likely interest, has fallen in many IS/IT related courses in recent years, by our count as much as 75 percent. This downward trend has become a frequent topic of conversation among IS academics at conferences and on discussion lists such as ISWorld. However, there is a small but growing number of IS educators who are reexamining what it means to study information systems. The purpose of this panel, presented at the 2007 International Conference on Information Systems (ICIS), was to present and discuss diverse and innovative approaches to IS/IT teaching and course development
Large-scale mobile audio environments for collaborative musical interaction.
ABSTRACT New application spaces and artistic forms can emerge when users are freed from constraints. In the general case of human-computer interfaces, users are often confined to a fixed location, severely limiting mobility. To overcome this constraint in the context of musical interaction, we present a system to manage large-scale collaborative mobile audio environments, driven by user movement. Multiple participants navigate through physical space while sharing overlaid virtual elements. Each user is equipped with a mobile computing device, GPS receiver, orientation sensor, microphone, headphones, or various combinations of these technologies. We investigate methods of location tracking, wireless audio streaming, and state management between mobile devices and centralized servers. The result is a system that allows mobile users, with subjective 3-D audio rendering, to share virtual scenes. The audio elements of these scenes can be organized into large-scale spatial audio interfaces, thus allowing for immersive mobile performance, locative audio installations, and many new forms of collaborative sonic activity
On-Sky Operations with the ALES Integral Field Spectrograph
The integral field spectrograph configuration of the LMIRCam science camera
within the Large Binocular Telescope Interferometer (LBTI) facilitates 2 to 5
m spectroscopy of directly imaged gas-giant exoplanets. The mode, dubbed
ALES, comprises magnification optics, a lenslet array, and direct-vision
prisms, all of which are included within filter wheels in LMIRCam. Our
observing approach includes manual adjustments to filter wheel positions to
optimize alignment, on/off nodding to track sky-background variations, and
wavelength calibration using narrow band filters in series with ALES optics.
For planets with separations outside our 1"x1" field of view, we use a
three-point nod pattern to visit the primary, secondary and sky. To minimize
overheads we select the longest exposure times and nod periods given observing
conditions, especially sky brightness and variability. Using this strategy we
collected several datasets of low-mass companions to nearby stars
iSKID: From integrated pilot scale runs to GMP implementation approach
One of the most compelling business reasons for integrated processing is the ability to de-risk capital investment due to a significantly more productive process that takes less space and fewer campaigns to generate clinical and commercial material. Boehringer Ingelheim and Pfizer developed the iSKID, a fully integrated and automated system that hydraulically links the perfusion bioreactor with several downstream unit operations (2xProtein A columns, continuous viral inactivation, AEX in flow through mode, and SPTFF). The Protein A elution cycles are discrete and separated by \u3e2hrs, allowing the ability to discard cycles that do not meet process specifications. The discreteness between product cycles and hydraulic linkage enables the sanitization between cycles for a robust bioburden control strategy. Each cycle is captured in a single use mixer (SUM), where the product is pooled in stable conditions until viral filtration, ultrafiltration/diafiltration and final filtration are performed in batch mode.
Identical iSKID prototypes at 100L scale were used at three different sites to generate product quality, process, and bioburden data from three different molecules. The data has been used to understand implementation gaps in GMP facilities and process platforms (CMC1/CMC2). In addition, the team identified specific items to present to the FDA’s Emerging Technology Team (ETT). These items include our strategies for batch definition, microbial control, and process control. In this talk, we will use the data generated from the consistency runs to elaborate on the robustness of the process and touch upon the strategies to be presented to the ETT
Concert recording 2013-03-31b
[Track 01]. Sweet Georgie fame / Blossom Dearie -- [Track 02]. Joy spring / Clifford Brown -- [Track 03]. Summer samba / Marcos Valle -- [Track 04]. Rhythm\u27ning / Thelonious Monk -- [Track 05]. One note samba / Antonio Carlos Jobim -- [Track 06]. In a sentimental mood / Duke Ellington -- [Track 07]. Recordame / Joe Henderson -- [Track 08]. Full house / Wes Montgomery -- [Track 09]. Cats and kittens / Peter Erskine -- [Track 10]. Primal prayer / Dan Haerle -- [Track 11]. Cookin\u27 Boox / Detroit Jackson
Volume 01
Introduction from Dean Dr. Charles Ross
Three Decades of Digging: Undergraduate Archeology at Longwood by Jessica Fields and Stephanie Neeley
Interactions of Allelopathy and Heat Stress in Plants by Derek W. Hambright and Mary E. Lehman
Inertial Electrostatic Confinement D-D Fusion Device: Construction and Simulation by Andrew R. Grzankowski
Shackled Nim by Zachary Johnson
Development of GC-MS and Chemometric Methods for the Analysis of Accelerants in Arson Cases by Boone M. Prentice
A Comparison of Image Analysis Methods in cDNA Microarrays by Ashley M. Swandby
Perceived Sexual Activity of Short and Long-Term Relationships by Victoria Morgan and Katie Williamson
Elderly Male Communication by Kristine G. Bender
Three Poems: “Adam and Eve and an Orange Tree”, “The Name of Everything Before Dying”, and “The ‘Poet Voice’” by Katelyn N. Romaine
There\u27s Nothing Like Dancing, After All : Marriage and Gender in the Dance Scenes of Jane Austen\u27s Novels by D. Nicole Swann
Two Poems: “Age Nine with Mother” and “The Apple That Crawls Away From the Tree” by Jessica Fox
Untitled by Mike McAteer
Room 9 by Alex Grabiec
Two Photographs: “Gracie” and “Emily” by Laura Nodtvedt
Bowling Lanes Night by Nick Costa
Two Paintings: “Can and Kettle” and “Scarecrow” by Rachel Wolfe
Exploring Henrik Ibsen\u27s “Perr Gynt” by Zack Dalton
Creative Writing Scholarship at Longwood University
Music Scholarship at Longwood – Senior Recital Arianne K. Burrus
Longwood University Theater – Peer Gyn
Simulating medium-spectral-resolution exoplanet characterization with SCALES angular/reference differential imaging
SCALES (Slicer Combined with Array of Lenslets for Exoplanet Spectroscopy) is
a 2 - 5 micron high-contrast lenslet-based integral field spectrograph (IFS)
designed to characterize exoplanets and their atmospheres. The SCALES
medium-spectral-resolution mode uses a lenslet subarray with a 0.34 x 0.36
arcsecond field of view which allows for exoplanet characterization at
increased spectral resolution. We explore the sensitivity limitations of this
mode by simulating planet detections in the presence of realistic noise
sources. We use the SCALES simulator scalessim to generate high-fidelity mock
observations of planets that include speckle noise from their host stars, as
well as other atmospheric and instrumental noise effects. We employ both
angular and reference differential imaging as methods of disentangling speckle
noise from the injected planet signals. These simulations allow us to assess
the feasibility of speckle deconvolution for SCALES medium resolution data, and
to test whether one approach outperforms another based on planet angular
separations and contrasts
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) based on multidimensional and comprehensive characterization, including mitochondrial DNA (mtDNA) and whole genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared to other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT up-regulation in cancer distinct from previously-observed amplifications and point mutations