“It’s Going To Be Just Turned Around”

Appearing in the Columbus Dispatch on April 21st 1924, Ray Evans’ cartoon titled “It’s Going to Be Just Turned Around” supports the Immigration Act of 1924 by displaying two different worlds in which different immigration policies are being applied: One with the immigration act, and one without

Exploring the role of ceftaroline in the treatment of community-acquired pneumonia

A critical appraisal and clinical application of File TM Jr, Low DE, Eckburg PB, Talbot GH, Friedland HD, Lee J, Llorens L, Critchley IA, Thye DA, FOCUS 1 investigators. FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia. J Antimicrob Chemother. 2011 Apr;66 Suppl 3:iii19-32. doi: 10.1093/jac/dkr09

Brewology Research Project: identifying the consumer values and motivations implicated in the rise of microbreweries in the Midwest

•This mixed-method study is a collaborative effort that draws on faculty expertise in marketing, tourism and communication. The study seeks to identify the consumer values and motivations implicated in the rise of microbreweries in the Midwest. Over the course of a few decades, craft beers have gained significant market share relative to large-scale commercial brands. The study aims to identify salient factors underlying the popularity of craft beers, taking into consideration both individual consumer preferences as well as how these intersect with socio-economic megatrends such as the “buy local” movement and agri-tourism. •The popularity of microbreweries is further evidenced in an increasing number of beer festivals and associated regional events. As these have become fixtures on annual calendars, additional questions regarding group affiliation and how it informs conceptions of self among craft beer enthusiasts’ demands exploring. Thus the proposed study further aims to shed light on social dimensions of these trends in a regional setting. Overall, results will not only fill gaps in knowledge concerning regional consumers, but will provide an understanding of shifting socio-cultural trends as reflected in the microbrewery movement at local levels

Pseudotyping exosomes for enhanced protein delivery in mammalian cells.

Exosomes are cell-derived nanovesicles that hold promise as living vehicles for intracellular delivery of therapeutics to mammalian cells. This potential, however, is undermined by the lack of effective methods to load exosomes with therapeutic proteins and to facilitate their uptake by target cells. Here, we demonstrate how a vesicular stomatitis virus glycoprotein (VSVG) can both load protein cargo onto exosomes and increase their delivery ability via a pseudotyping mechanism. By fusing a set of fluorescent and luminescent reporters with VSVG, we show the successful targeting and incorporation of VSVG fusions into exosomes by gene transfection and fluorescence tracking. We subsequently validate our system by live cell imaging of VSVG and its participation in endosomes/exosomes that are ultimately released from transfected HEK293 cells. We show that VSVG pseudotyping of exosomes does not affect the size or distributions of the exosomes, and both the full-length VSVG and the VSVG without the ectodomain are shown to integrate into the exosomal membrane, suggesting that the ectodomain is not required for protein loading. Finally, exosomes pseudotyped with full-length VSVG are internalized by multiple-recipient cell types to a greater degree compared to exosomes loaded with VSVG without the ectodomain, confirming a role of the ectodomain in cell tropism. In summary, our work introduces a new genetically encoded pseudotyping platform to load and enhance the intracellular delivery of therapeutic proteins via exosome-based vehicles to target cells

QCA-Based Majority Gate Design under Radius of Effect-Induced Faults

This paper presents reliable QCA cell structures for designing single clock-controlled majority gates with a tolerance to radius of effect-induced faults, for use as a basic building component for carry look-ahead adder. Realizable quantum computing is still well in the future due to the complexity of the quantum mechanics that govern them. In this regard, QCA-based system design is a challenging task since each cell\u27\u27s state must interact with all the cells that are in its energy-effective range in its clocking zone, referred to as its radius of effect. This paper proposes a design approach for majority gates to overcome the constraints imposed by the radius of effect of each cell with respect to clock controls. Radius of effect induces faults that lead to constraints on the clocking scheme of majority gates. We show majority gate structures that operate with multiple radius of effect-induced faults under a single clock control. The proposed design approach to a single clock controlled majority gate ultimately facilitate more efficient and flexible clocking schemes for complex QCA designs

Nudging Students Beyond the FAFSA: The Impact of University Outreach on Financial Aid Behaviors and Outcomes

A growing body of research indicates that proactive outreach from high schools and college access organizations about college preparation tasks, and specifically focusing on completing the Free Application for Federal Student Aid (FAFSA), results in increased college enrollment. Comparatively less attention has been paid to the role of colleges and universities in this outreach and outreach relating to additional financial aid barriers that students face while applying to college, such as the CSS PROFILE form. In this article we investigated, through an inter-university collaboration, the effect of sending targeted, semi-personalized text messages to students during the college application process about important financial aid deadlines, making salient the specific forms required and prompting students to plan specific times to complete these tasks. The intervention increased CSS PROFILE filing by 3.1-4.3 percentage points, where the estimates and their significance varied depending on the comparison group. Impacts on student enrollment did not accompany these filing impacts. Results from our collaboration support the idea that colleges and universities have an important role to play in outreach to applicants relating to important financial aid tasks. The paper includes a discussion of the promises and challenges of this outreach with recommendations for practitioners

Comparing Visitor Perceptions, Characteristics, and Support for Management Actions Before and During a Pilot Timed Entry System at Arches National Park

Over the past decade, many national park units in the United States broke visitation records. Arches National Park (UT, USA) is no exception. Between 2011 and 2021, visitation increased 74%. As part of considering management options to address the issues from sustained and concentrated visitation, Arches implemented a pilot timed entry system from 3 April to 3 October 2022. This article compares visitor perceptions, characteristics, and support for management actions before and during the pilot timed entry system using data from visitor intercept surveys. Findings suggest visitors experience quality improved across the park and on hiking trails during the pilot timed entry system. Visitor characteristics were extremely similar, and there were no differences in local residency, group size, vehicle occupancy, race, ethnicity, first time visitation, education level, or household income. Visitors were more likely to plan for the trip further in advance and were less likely to re-enter the park during the pilot timed entry system. Lastly, visitors demonstrated more support for timed entry and lower levels of support for expanding parking, site specific reservations, and temporary closures during the pilot timed entry system. These results reflect unique insights for managers considering managed access systems like timed entry to sustainably manage visitor use in parks and protected areas