Therapists\u27 and Families\u27 Views on Family Involvement in Adolescent Residential Treatment

This study of 24 therapists and 64 family members representing 109 adolescent residents of six residential treatment centers aimed to better understand therapists\u27 and family members\u27 points of view about family involvement in residential treatment for troubled adolescents. The study also provided the therapists\u27 and family members\u27 recommendations for family involvement in residential treatment. Findings from this mixed-methods study suggest that (a) the families from this study were involved in many different ways in their adolescents\u27 treatment, including phone calls, visits to the treatment center, participation in therapy, and so forth; (b) there were areas in which therapists and family members agreed (e.g., whether families used phone calls as a form of contact) and areas in which they disagreed about how involved the families were in treatment and therapy (e.g., how often any family member was involved in therapy with the adolescent); and (c) the therapists and family members recommended that families should be involved in therapy but recommend some forms of involvement over others

Aerobic Capacity Independently Predicts Central Augmentation Index Among Apparently Healthy Adults

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Acute Changes in Levels of Inflammatory Proteins After a Single Bout of HIIT

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Four Months of Kettlebell Training Improves Muscle Strength and Functional Outcomes in Older Adults

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Sex Differences in Augmentation Index in Response to Acute Dynamic Exercise

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Assessing Acute Muscle Changes Using Ultrasound

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Compartmentalization of Cells Bearing "Rheumatic” Cell Surface Antigens in Peripheral Blood and Tonsils in Rheumatic Heart Disease

Monoclonal antibodies that recognize "rheumatic” antigens of peripheral blood non-T cells were used to study the compartmentalization of such cells in peripheral blood and tonsils of individuals with rheumatic heart disease (RHD) and suitable control subjects. The peripheral blood of most (71%) of the 42 individuals with RHD contained cells reacting with monoclonal antibody 83S19.23 or 256S.10, whereas these cells were present in only 17% of the 41 control subjects (P < .02). However, none of 21 individuals with RHD had such cells in their tonsils, although they were present in the tonsils of 50% of the 40 control subjects (P < .03). These results may reflect a failure in RHD of organ-specific homing of cells with the epitopes recognized by the antibodies. The presence of these cells in tonsils may be important in the immune response to streptococcal pharyngeal infection, and their absence in RHD may be involved in the unusual immune responses characteristic of this diseas

An Interspecies Signaling System Mediated by Fusaric Acid Has Parallel Effects on Antifungal Metabolite Production by Pseudomonas protegens Strain Pf-5 and Antibiosis of Fusarium spp.

Pseudomonas protegens strain Pf-5 is a rhizosphere bacterium that suppresses soilborne plant diseases and produces at least seven different secondary metabolites with antifungal properties. We derived mutants of Pf-5 with single and multiple mutations in biosynthesis genes for seven antifungal metabolites: 2,4-diacetylphoroglucinol (DAPG), pyrrolnitrin, pyoluteorin, hydrogen cyanide, rhizoxin, orfamide A, and toxoflavin. These mutants were tested for inhibition of the pathogens Fusarium verticillioides and Fusarium oxysporum f. sp. pisi. Rhizoxin, pyrrolnitrin, and DAPG were found to be primarily responsible for fungal antagonism by Pf-5. Previously, other workers showed that the mycotoxin fusaric acid, which is produced by many Fusarium species, including F. verticillioides, inhibited the production of DAPG by Pseudomonas spp. In this study, amendment of culture media with fusaric acid decreased DAPG production, increased pyoluteorin production, and had no consistent influence on pyrrolnitrin or orfamide A production by Pf-5. Fusaric acid also altered the transcription of biosynthetic genes, indicating that the mycotoxin influenced antibiotic production by Pf-5 at the transcriptional level. Addition of fusaric acid to the culture medium reduced antibiosis of F. verticillioides by Pf-5 and derivative strains that produce DAPG but had no effect on antibiosis by Pf-5 derivatives that suppressed F. verticillioides due to pyrrolnitrin or rhizoxin production. Our results demonstrated the importance of three compounds, rhizoxin, pyrrolnitrin, and DAPG, in suppression of Fusarium spp. by Pf-5 and confirmed that an interspecies signaling system mediated by fusaric acid had parallel effects on antifungal metabolite production and antibiosis by the bacterial biological control organism