Addison, O

Dobrosielski, D A

Dondero, K

Landers-Ramos, R Q

Mázala, D A.G

Siok, D

Zabriskie, H A

English

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           Acute Changes in Levels of Inflammatory Proteins After a Single Bout of HIIT     Davi A.G. Mázala1,2, Kathleen Dondero1, Dakota Siok1, Hannah A. Zabriskie1, Devon A. Dobrosielski1, Odessa Addison3,4, Rian Q. Landers-Ramos1. 1Towson University, Towson, MD; 2Children’s National Medical Center, Washington, DC; 3University of Maryland School of Medicine, Baltimore, MD; 4Veterans Affairs Medical Center, Baltimore, MD  High Intensity Functional Training (HIFT) is a type of high intensity training involving multi-joint movements emphasizing functional outcomes. While studies have shown that high intensity training can elicit a plethora of chronic health benefits, not many studies have evaluated the acute effects of HIFT on circulating inflammatory proteins that might also play a role in early phases of exercise-induced adaptations. PURPOSE: To evaluate acute changes in plasma levels of inflammatory proteins in response to a single session of HIFT. METHODS: The workout consisted of 4 sets of following body-weight exercises (15 reps of each): two lunge variations, jump squats, and burpees. Plasma samples were collected from recreationally active men (n=7) and women (n=6) (18-45 yrs) – samples were collected before exercise (pre), 15min post- and 24h post-completion of the training session and frozen until analyses. Levels of different inflammatory factors were evaluated by using the Inflammation 20-Plex Human ProcartaPlex™ Panel. RESULTS: Of the 20 different inflammatory proteins analyzed, 10 showed an increase from pre vs. 15min post exercise (TNFα: 42%; GM-CSF: 9%; IFNα: 49%; IFNγ: 24%; IL-1 α: 61%; IL-1 β: 62%; IL-6: 17%; IL-8: 19%; IL-13: 20%; IL-17A: 21%; p<0.05 for all), while 3 showed a decrease from pre vs. 15min post exercise (CD62E: 25%; ICAM-1: 27%; IL-12p70: 8%; p<0.05 for all). Additionally, 10 proteins showed a decrease from 15min post vs. 24h post exercise (CD62P: 20%; TNFα: 35%; GM-CSF: 7%; IFNα: 28%; IFNγ: 36%; IL-1α: 37%; IL-1β: 32%; IL-6: 18%; IL-8: 14%; IL-13: 23%; IL-17A: 17%; p<0.05 for all), while only 1 protein showed an increase from 15min post vs. 24h post exercise (IP-10: 29%; p<0.05). Two proteins showed a decrease from pre vs. 24h post exercise (CD62E: 18%; IL-12p70: 14%; p<0.05 for all) and 1 protein showed an increase from pre vs. 24h post exercise (IP-10: 19%; p<0.05) - no changes were reported for IL-4, MCP-1, MIP-1α, MIP-1β, nor IL-10. CONCLUSION: Our results demonstrate that HIFT induces acute changes in in plasma levels of inflammatory proteins, but that their levels seem to return to baseline values within 24h post exercise.    Supported by Towson University Department of Kinesiology (RQL, DAGM), Towson University Faculty Development & Research Committee (DAGM) and Towson University Research Impact Award (DS)  Mid Atlantic Regional Chapter of the American College of Sports Medicine  45th Annual Scientific Meeting, November 4th- 5th, 2022 Conference Proceedings International Journal of Exercise Science, Issue 9, Volume 11 

Acute Changes in Levels of Inflammatory Proteins After a Single Bout of HIIT

https://digitalcommons.wku.edu/cgi/viewcontent.cgi?article=6667&context=ijesab

Acute Changes in Levels of Inflammatory Proteins After a Single Bout of HIIT

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