Alcohol Intake and Abnormal Expression of Brf1 in Breast Cancer.

Breast cancer is the most common malignant disease of females. Overall, one woman in every nine will get breast cancer at some time in her life. Epidemiological studies have indicated that alcohol consumption has most consistently been associated with breast cancer risk. However, the mechanism of alcohol-associated breast cancer remains to be addressed. Little is known about the effects of alcohol consumption on Brf1 (TFIIIB-related factor 1) expression and RNA Pol III gene (RNA polymerase III-dependent gene) transcription, which are responsible for protein synthesis and tightly linked to cell proliferation, cell transformation, and tumor development. Emerging evidences have indicated that alcohol induces deregulation of Brf1 and Pol III genes to cause the alterations of cell phenotypes and tumor formation. In this paper, we summarize the progresses regarding alcohol-caused increase in the expression of Brf1 and Pol III genes and analysis of its molecular mechanism of breast cancer. As the earlier and accurate diagnosis approach of breast cancer is not available yet, exploring the molecular mechanism and identifying the biomarker of alcohol-associated breast cancer are especially important. Recent studies have demonstrated that Brf1 is overexpressed in most ER+ (estrogen receptor positive) cases of breast cancer and the change in cellular levels of Brf1 reflects the therapeutic efficacy and prognosis of this disease. It suggests that Brf1 may be a potential diagnosis biomarker and a therapeutic target of alcohol-associated breast cancer

Integration of differential interferometric synthetic aperture radar and persistent scatterer interferometric approaches to assess deformation in enshi city, hubei, China

Land surface deformation can severely damage socioeconomic living conditions around the world. This study aimed to identify the Shaziba landslide and further assess deformation activities in Enshi city. For this purpose, the sentinel-1 C-bands data acquired in ascending directions were processed with Sentinel Application Platform and Stanford Method for Persistent Scatterers (StaMPS) software packages. Our results revealed the location of a landslide that occurred on 21 July 2020 in the Shaziba area, Enshi Prefecture. More interesting deformation results were found in Enshi city for the first time with a deformation range from −51.6 to 54.2 mm/year. We conducted a thorough observation of different urban infrastructures such as commercial and residential buildings, roads, bridges, and airports in Enshi city and along the Qingjiang River to evaluate land surface deformation. Observations revealed that there are a number of influencing factors contributing to disturbing the natural environment and resources in Enshi Prefecture. Of these influencing factors, intensive rainfall is a major cause as are the infiltration of rainfall into the subsurface Silurian strata together with the load of infrastructure in the study area. If this issue is not addressed it could lead to devastating geo-hazard disasters in the future. Scientific approaches to determine various causes of frequent geo-hazards in this region are of great significance for developing early warning systems for disasters and ensuring the safety of residents’ lives and property

Determination of 17 aldehydes in Baijiu (Chinese liquor) by direct injection gas chromatography

Objective: To explore the content of aldehydes in Baijiu. Methods: A method for the determination of 17 aldehydes in Baijiu was established, and the methodological performance indexes were studied using statistics. Results: Through statistical analysis, the detection limit of 17 aldehydes in Baijiu was determined to be 0.7~5.9 mg/L, the limit of quantification was 1.9~14.6 mg/L, which passes the quality inspection of the calibration curve within the range of 0.6~320.0 mg/L, and the linear relationship meets the requirements. The recovery rate of intermediate standard addition in Baijiu was 73%~114%, the coefficient of variation in the laboratory was ≤11%, and the accuracy deviation range was -18.7%~8.0%. Conclusion: The method can be used for the determination of various aldehydes in Baijiu

The α1‐adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway

Elevated body iron stores are associated with hypertension progression, while hypertension is associated with elevated plasma catecholamine levels in patients. However, there is a gap in our understanding of the connection between catecholamines and iron regulation. Hepcidin is a key iron‐regulatory hormone, which maintains body iron balance. In the present study, we investigated the effects of adrenaline (AD) and norepinephrine (NE) on hepatic hepcidin regulation. Mice were treated with AD, NE, phenylephrine (PE, α1‐adrenergic receptor agonist), prazosin (PZ, α1‐adrenergic receptor antagonist), and/or propranolol (Pro, β‐adrenergic receptor antagonist). The levels of hepcidin, as well as signal transducer and activator of transcription 3 (STAT3), ferroportin 1 (FPN1), and ferritin‐light (Ft‐L) protein in the liver or spleen, were assessed. Six hours after AD, NE, or PE treatment, hepatic hepcidin mRNA levels increased. Pretreatment with PZ, but not Pro, abolished the effects of AD or NE on STAT3 phosphorylation and hepatic hepcidin expression. When mice were treated with AD or NE continuously for 7 days, an increase in hepatic hepcidin mRNA levels and serum hepcidin concentration was also observed. Meanwhile, the expected downstream effects of elevated hepcidin, namely decreased FPN1 expression and increased Ft‐L protein and non‐heme iron concentrations in the spleen, were observed after the continuous AD or NE treatments. Taken together, we found that AD or NE increase hepatic hepcidin expression via the α1‐adrenergic receptor and STAT3 pathways in mice. The elevated hepatic hepcidin decreased FPN1 levels in the spleen, likely causing the increased iron accumulation in the spleen

The role of electrocochleography and the caloric test in predicting short-term recurrence of benign paroxysmal positional vertigo

ObjectiveThe study aimed to assess the value of physiological tests for evaluating inner ear function in predicting the short-term recurrence of benign paroxysmal positional vertigo (BPPV).Materials and methodsThe clinical information of all idiopathic BPPV patients who were treated in our clinic between February 2021 and December 2022 were reviewed. All patients included in the study had completed audiology examinations including pure tone audiometry, electrocochleography (EcochG), auditory brainstem response, and vestibular function examination such as the vestibular caloric test. The relationships between the results of the above tests and short-term recurrent BPPV were analyzed.ResultsA total of 96 patients with unilateral idiopathic BPPV were included for analysis. The numbers of non-recurrent patients and recurrent patients were 57 (59.4%) and 39 (40.6%), respectively. Only the results of EcochG and the caloric test showed significant differences between non-recurrent and recurrent patients (both P < 0.05). The results of these two tests were also found to be independently predictive of short-term recurrence (both P < 0.05). The non-recurrence rate for patients with normal results in both tests reached up to 78.3%, which was significantly higher than that for patients with abnormal results in both tests, 28.6% (P < 0.05).ConclusionEndolymphatic hydrops and canal paresis were independent risk factors for short-term recurrent BPPV. Additional treatments should be considered to reduce the recurrence rate, including dehydration treatment and vestibular rehabilitation

Gelsemium elegans Poisoning: A Case with 8 Months of Follow-up and Review of the Literature

BackgroundGelsemium elegans (G. elegans) is a toxic plant indigenous to Southeast Asia. It is highly poisonous due to its strong respiratory depressive effect. However, G. elegans poisoning cases have not been summarized comprehensively and are rarely reported in English journals. Furthermore, none of the present reports present prognosis in detail.Case presentationA 26-year-old female was found comatose at home and brought to the hospital with deep coma, hypoxia, and acidosis. After mechanical ventilation for hours, the patient recovered from coma with sequelae of impaired short-term memory, disorientation, and childish behaviors. Brain magnetic resonance imaging (MRI) showed bilateral hippocampus and basal ganglia damage due to hypoxia. During 8 months of follow-up, both her symptoms and brain MRI scan improved significantly.ConclusionG. elegans is highly toxic. Although patients may die within 30 min due to its strong respiratory depressive effect, they can survive with timely respiratory support and enjoy gradual improvement without delayed postanoxic encephalopathy

Current understanding of CTLA-4: from mechanism to autoimmune diseases

Autoimmune diseases (ADs) are characterized by the production of autoreactive lymphocytes, immune responses to self-antigens, and inflammation in related tissues and organs. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is majorly expressed in activated T cells and works as a critical regulator in the inflammatory response. In this review, we first describe the structure, expression, and how the signaling pathways of CTLA-4 participate in reducing effector T-cell activity and enhancing the immunomodulatory ability of regulatory T (Treg) cells to reduce immune response, maintain immune homeostasis, and maintain autoimmune silence. We then focused on the correlation between CTLA-4 and different ADs and how this molecule regulates the immune activity of the diseases and inhibits the onset, progression, and pathology of various ADs. Finally, we summarized the current progress of CTLA-4 as a therapeutic target for various ADs

Mapping of nighttime light trends and refugee population changes in Ukraine during the Russian–Ukrainian War

The nighttime lights accurately and coherently depict how humans live. This study uses nighttime light measurements to quantify changes in nighttime lighting and refugee population in Ukraine before and after the war. We combined the Theil–Sen estimator with the M-K test to explore the trends of nighttime light. In addition, we constructed a linear model using nighttime light data and a portion of the UNHCR refugee data. Our results reveal that 1 week after the start of the Russo-Ukrainian War, the nighttime light area and the average nighttime light DN value in Ukraine exhibited a steep decline of about 50 percent. Our findings showed taht refugee population changes calculated through models and nighttime light data were mostly consistent with UNHCR data. We thought that the nighttime light data might be used directly to dynamically estimate changes in the refugee movement throughout the war. Nighttime light changes has significant implications for international humanitarian assistance and post-war reconstruction