Chemotherapy and prognosis in advanced thymic carcinoma patients

OBJECTIVE: The role of chemotherapy in treating advanced thymic carcinoma is unclear. The purpose of the current study was to investigate the efficacy of chemotherapy and the prognostic factors for patients with advanced thymic carcinoma. METHODS: A retrospective review of the medical records of 86 patients treated with chemotherapy for advanced thymic carcinoma was conducted between 2000 and 2012 at our institution. The clinical characteristics, chemotherapy regimens and prognostic factors were analyzed. Survival curves were plotted using the Kaplan-Meier method and the Cox proportional hazard model was used for multivariate analysis. RESULTS: Of the 86 patients, 56 were male and 30 were female. The median survival time was 24.5 months. For the first-line chemotherapy treatment, the objective response rate was 47.7% and the disease control rate was 80.2%. The median progression-free survival for all patients was 6.5 months for first-line chemotherapy. No significant differences in progression-free survival were observed among the different chemotherapy regimens. Multivariate analyses revealed that the prognostic factors for overall survival included performance status (p=0.043), histology grade (p=0.048), and liver metastasis (p=0.047). CONCLUSION: Our results suggest that there is no difference in efficacy between multiagent and doublet regimens. The prognosis of patients with advanced thymic carcinoma can be predicted based on histological grade, liver metastasis and performance status

Distilling Inter-Class Distance for Semantic Segmentation

Knowledge distillation is widely adopted in semantic segmentation to reduce the computation cost.The previous knowledge distillation methods for semantic segmentation focus on pixel-wise feature alignment and intra-class feature variation distillation, neglecting to transfer the knowledge of the inter-class distance in the feature space, which is important for semantic segmentation. To address this issue, we propose an Inter-class Distance Distillation (IDD) method to transfer the inter-class distance in the feature space from the teacher network to the student network. Furthermore, semantic segmentation is a position-dependent task,thus we exploit a position information distillation module to help the student network encode more position information. Extensive experiments on three popular datasets: Cityscapes, Pascal VOC and ADE20K show that our method is helpful to improve the accuracy of semantic segmentation models and achieves the state-of-the-art performance. E.g. it boosts the benchmark model("PSPNet+ResNet18") by 7.50% in accuracy on the Cityscapes dataset.Comment: IJCAI-ECAI2022 Long Ora

Modern International Park City and Ecological Civilization Education Practice: Taking Chengdu Tianfu Greenway as the Core

In the comprehensive development of modern park city and ecological civilization education, Chengdu has gradually explored its own path with international characteristics. The positioning of Chengdu as a “modern and beautiful park city” is an innovation proposed by Mr. Xi Jinping in recent years. This concept not only combines the geographical location of Chengdu with the regional characteristics of the western environment, but also highly respects the historical laws of the development of Chengdu’s Bashu civilization for thousands of years. At the same time, it also absorbs Howard’s “pastoral city” dream and Mountford, the theme of Gedde’s “Organic City Theory” has corrected the shortcomings of Le Corbusier’s mechanized functional space view and presented distinctive Chinese characteristics in theoretical innovation and the development of ecological civilization education. The outstanding performance is the organic integration of the development of Tianfu ecological civilization, the cultural education of Bashu and the aesthetic design practice, the creation of the international brand image of Chengdu’s “three cities and three capitals” and the innovative practical experience results of the dream of “beautiful and livable park city”

Emerging Spatio-temporal Hot Spot Analysis of Beijing Subsidence Trend Detection Based on PS-InSAR

Scholars have done a lot of research on urban settlement, but it is difficult to give consideration to the temporal and spatial attributes of settlement at the same time in its display and analysis. Most of them focused on the analysis of regional settlement, single point settlement curve and settlement rate map at a certain time, but few combined time and space for collaborative analysis. Therefore, in this paper, 32 scenes Sentinel-1B SAR data are used to obtain settlement data of Beijing via PS-InSAR method. Secondly, combined with the temporal and spatial attributes of settlement results, the subsidence law revealed by using spatio-temporal cube slicing and attribute filtering. Finally, subsidence development trend and the detection of abnormal subsidence are explored by emerging hot spots (ESH) analysis. The experimental results show that the settlement funnel center in Beijing is mainly concentrated near the junction of Chaoyang district and Tongzhou district. The settlement range tends to expand. There are several local continuous subsidence areas in the settlement oscillating area. Spatio-temporal analysis makes the development trend of urban settlement more intuitive. Emerging hotspot analysis combined with Getis-Ord Gi* statistics and Mann-Kendall trend test could more effectively analyze the settlement trend of the study area and detect new potential settlement centers, so that to provide auxiliary decision-making for urban safety early warning and city development

Adaptive motion artefact reduction in respiration and ECG signals for wearable healthcare monitoring systems

Wearable healthcare monitoring systems (WHMSs) have received significant interest from both academia and industry with the advantage of non-intrusive and ambulatory monitoring. The aim of this paper is to investigate the use of an adaptive filter to reduce motion artefact (MA) in physiological signals acquired by WHMSs. In our study, a WHMS is used to acquire ECG, respiration and triaxial accelerometer (ACC) signals during incremental treadmill and cycle ergometry exercises. With these signals, performances of adaptive MA cancellation are evaluated in both respiration and ECG signals. To achieve effective and robust MA cancellation, three axial outputs of the ACC are employed to estimate the MA by a bank of gradient adaptive Laguerre lattice (GALL) filter, and the outputs of the GALL filters are further combined with time-varying weights determined by a Kalman filter. The results show that for the respiratory signals, MA component can be reduced and signal quality can be improved effectively (the power ratio between the MA-corrupted respiratory signal and the adaptive filtered signal was 1.31 in running condition, and the corresponding signal quality was improved from 0.77 to 0.96). Combination of the GALL and Kalman filters can achieve robust MA cancellation without supervised selection of the reference axis from the ACC. For ECG, the MA component can also be reduced by adaptive filtering. The signal quality, however, could not be improved substantially just by the adaptive filter with the ACC outputs as the reference signals.Municipal Science & Technology Commission. Beijing Natural Science Foundation (Grants 3102028 and 3122034)General Logistics Science Foundation (Grant CWS11C108)National Institutes of Health (U.S.) (National Institute of General Medical Sciences (U.S.). Grant R01- EB001659)National Institutes of Health (U.S.) (National Institute for Biomedical Imaging and Bioengineering (U.S.) Cooperative Agreement U01- EB-008577

Effects of slow and regular breathing exercise on cardiopulmonary coupling and blood pressure

Investigation of the interaction between cardiovascular variables and respiration provides a quantitative and noninvasive approach to assess the autonomic control of cardiovascular function. The aim of this paper is to investigate the changes of cardiopulmonary coupling (CPC), blood pressure (BP) and pulse transit time (PTT) during a stepwise-paced breathing (SPB) procedure (spontaneous breathing followed by paced breathing at 14, 12.5, 11, 9.5, 8 and 7 breaths per minute, 3 min each) and gain insights into the characteristics of slow breathing exercises. RR interval, respiration, BP and PTT are collected during the SPB procedure (48 healthy subjects, 27 ± 6 years). CPC is assessed through investigating both the phase and amplitude dynamics between the respiration-induced components from RR interval and respiration by the approach of ensemble empirical mode decomposition. It was found that even though the phase synchronization and amplitude oscillation of CPC were both enhanced by the SPB procedure, phase coupling does not increase monotonically along with the amplitude oscillation during the whole procedure. Meanwhile, BP was reduced significantly by the SPB procedure (SBP: from 122.0 ± 13.4 to 114.2 ± 14.9 mmHg, p < 0.001, DBP: from 82.2 ± 8.6 to 77.0 ± 9.8 mmHg, p < 0.001, PTT: from 172.8 ± 20.1 to 176.8 ± 19.2 ms, p < 0.001). Our results demonstrate that the SPB procedure can reduce BP and lengthen PTT significantly. Compared with amplitude dynamics, phase dynamics is a different marker for CPC analysis in reflecting cardiorespiratory coherence during slow breathing exercise. Our study provides a methodology to practice slow breathing exercise, including the setting of target breathing rate, change of CPC and the importance of regular breathing. The applications and usability of the study results have also been discussed.National Natural Science Foundation (China) (Grant Number: 61471398)Beijing Natural Science Foundation (Grant Number: 3122034)General Logistics Science Foundation (Grant Number: CWS11C108)National Key Technology Research and Development Program (Grant Numbers: 2013BAI03B04, 2013BAI03B05

Realization of multiple charge density waves in NbTe2 at the monolayer limit

Abstract: Layered transition-metal dichalcogenides (TMDCs) down to the monolayer (ML) limit provide a fertile platform for exploring charge-density waves (CDWs). Though bulk NbTe2 is known to harbor a single axis 3*1 CDW coexisting with non-trivial quantum properties, the scenario in the ML limit is still experimentally unknown. In this study, we unveil the richness of the CDW phases in ML NbTe2, where not only the theoretically predicted 4*4 and 4*1 phases, but also two unexpected sqrt(28)*sqrt(28) and sqrt(19)*sqrt(19) phases, can be realized. For such a complex CDW system, we establish an exhaustive growth phase diagram via systematic efforts in the material synthesis and scanning tunneling microscope characterization. Moreover, we report that the energetically stable phase is the larger scale order (sqrt(19)*sqrt(19)), which is surprisingly in contradiction to the prior prediction (4*4). These findings are confirmed using two different kinetic pathways, i.e., direct growth at proper growth temperatures (T), and low-T growth followed by high-T annealing. Our results provide a comprehensive diagram of the "zoo" of CDW orders in ML 1T-NbTe2 for the first time and offer a new material platform for studying novel quantum phases in the 2D limit