64 research outputs found
A first Alps - dedicated gravity data set - introduction and status of the AlpArray gravity field activities
In this contribution, activities of the AlpArray Gravity Research Group (AAGRG) are introduced. Since 2018, this
group in the frame of the AlpArray project (http://www.alparray.ethz.ch/en/home/) prepares gravity and other data
sets to support multidisciplinary goals of the project. It is focused on the mantle, plate and surface processes in the Alps-Apennines-Carpathians-Dinarides orogenic system.
In 2018, the AAGRG set up its own methodology guidelines and assembled available land-gravity data and
digital elevation model (DEM) data from all the participating countries. Our presentation targets especially three
goals: 1) to introduce AAGRG activities as an integral part of the AlpArray project for studying Alpine orogeny \u2013 a
goal that by definition requires international cooperation, 2) to review the input data and the works accomplished so
far, and, 3) to discuss the steps to be taken to produce detailed gravity maps of the region \u2013 the first Alps-dedicated
gravity field data set. We plan to prepare gravity grids in a homogeneous processing approach of either 2x2 km or
4x4 km resolution, depending on the coverage and data quality. The final data sets will be made public in late 2019.
A special emphasis is put on the calculation of the Bouguer anomaly using ellipsoidal rather tha normal
heights. For calculating topographic effects the preference is given to local DEMs, where available, as they often
provide higher quality and spatial resolutions. The public gravity data sets are evaluated with the high-resolution
geopotential models like EIGEN-6C4 or EGM2008 \u2013 a useful means for identifying biases in the data coming
from various countries and campaigns
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
Meeting abstrac
Systemic neutrophil-to-lymphocyte ratio in colorectal cancer: the relationship to patient survival, tumour biology and local lymphocytic response to tumour
Background: Colorectal cancer (CRC) is a major cause of mortality and morbidity. The impact of inflammatory biomarkers (C-reactive protein etc.) on CRC is increasingly studied including systemic neutrophil-to-lymphocyte ratio (NLR) as they seem to predict outcome. Methods: All patients who underwent curative resection for CRC from 2000 to 2004 at Leeds Teaching Hospitals NHS Trust had pre-operative NLR calculated. Demographic, histopathological and survival data were collected. Tissue microarrays were created and stained to determine the mismatch repair (MMR) protein status of each tumour. Local lymphocytic response to the tumour was assessed and graded. Results: About 358 patients were eligible. Of these 88 had an NLR greater than or equal to5, which predicted lower overall survival and greater disease recurrence. A high NLR is associated with higher pT- and pN-stage and a greater incidence of extramural venous invasion. MMR protein status was not associated with NLR. A pronounced lymphocytic reaction at the invasive margin (IM) indicated a better prognosis and was associated with a lower NLR. Conclusion: Neutrophil-to-lymphocyte ratio predicts disease-free and overall survival and is associated with a more aggressive tumour phenotype. The lymphocytic response to tumour at the IM is associated with NLR however dMMR is not. Neutrophil-to-lymphocyte ratio is a cheap, easy-to-access test that predicts outcome in CRC
Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer
Neutrophil-to-lymphocyte ratio is a prognostic marker in bladder cancer patients after radical cystectomy
Patent ductus arteriosus: The rare cause of left bronchial obstruction in neonate with pulmonary atresia
A new land \u2013 based gravity data set for the Alps and adjacent regions \u2013 the AAGRG at work
A pan-Alpine gravity data map, homogeneous regarding input data sets, applied methods and corrections as well ascommon reference frames, is not available yet. Therefore, all countries around the Alps have agreed to contributewith gravity data and/or gravity data processing techniques to a recompilation of the alpine gravity field in theframe of the AlpArray Gravity Research Group (AAGRG). Also to collaborate with other groups in AlpArray.In the last year group members met two times to set up guidelines for joint processing and homogenizationof existing gravity data sets. Following the results and appointments of the last technical AAGRG meeting inBratislava October 2018, the members of the 9 participating countries decided to present a first data set of theBouguer gravity field in September 2019 on a 2km x 2km or 4km x 4km grid for the public. Other compilationswill follow: maps of Free Air Gravity, regional field and the corresponding residual gravity field. These new datasets will be available to all AlpArray partners for interdisciplinary work and modelling.This new Bouguer anomaly will be station completed with at least 1 point/4 km2 resolution and compiledaccording to the most modern criteria. In general, even though global models like SRTM1 perform well, thepreference was given to local DEMs - if available. Two software packages for topographic corrections on thebase of ellipsoidal heights are available: \u201cTOPOSK\u201d, developed by Slovak colleagues, and the \u201cadaptive masscorrection\u201d from the Kiel group. The results of both methods are being tested and compared. The geophysicalindirect effect and its determination are also taken into account. Special emphasis is put on the lakes in the studyarea. They have a considerable effect on the gravity of stations that lie at their edges (for example, the partiallyvery deep reservoirs in the Alps). In the Ligurian and the Adriatic seas ship data of the Bureau Gravim\ue9triqueIinternational will be used. Although not unproblematic, these data got the preference over satellite data.In the AAGRG, long discussions were centered on the calculation of long-distance effects of topogra-phy/bathymetry and its compensating masses (root). The first compilation of the AA Bouguer anomaly mapwill, however, be prepared WITHOUT taking long-distance effects in account. The group agreed to extendthe correction radius to the Hayford zone O2(167 km). All topographic corrections will be calculated as masscorrections between the physical surface and the ellipsoidal reference. The group further discussed the necessityof a 3D interpolation of the gravity grid values. Although a 3D interpolation would be required from themethodological-theoretical point of view (the problem is the non-identical gravity and height grids), it was decidedto perform a 2D interpolation in the first compilation - the method of Kriging shall be applied. The poster will visualize the mentioned correction effects and illuminate the necessity of a complete revision of the existing land based Alpine gravity data
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