Seroprevalence of cytomegalovirus and rubella among pregnant women in western Sudan

<p>Abstract</p> <p>Background</p> <p>Maternal cytomegalovirus (CMV) and rubella infections have adverse neonatal outcomes. Basic epidemiological data concerning CMV and rubella is necessary for health planners and care providers.</p> <p>Methods</p> <p>A cross sectional study was conducted at El-Rahad hospital, Sudan to investigate seroprevalence of CMV and rubella infections and associated possible risk factors among pregnant women. Structured questionnaires were used to gather socio-demographic data and ELISA was used to detect CMV and rubella infections using IgG and IgM.</p> <p>Results</p> <p>Out of 231 pregnant women, 167 (72.2%) and 151 (65.3%) were CMV-IgG and rubella-IgG positive, respectively. Only 6 (2.5%) and 8 women (3.4%) were CMV-IgM and rubella-IgM positive, respectively. While, high parity (OR = 14.7, 95%CI = 1.7 - 123.6; <it>P </it>= 0.01] and illiteracy (OR = 3.0, CI = 1.4 - 6.5; <it>P </it>= 0.004) were significantly associated with seropostive CMV-IgG in multivariate analysis, none of the other obstetrical and medical characteristics were significantly associated with CMV or rubella infections.</p> <p>Conclusion</p> <p>CMV prevalence was 72.2% and rubella susceptibility among pregnant women was 34.6%. Rubella vaccine and routine screening for rubella and CMV should be introduced for pregnant women in this setting. Further research is needed.</p

Resorbable versus titanium plates for orthognathic surgery.

BACKGROUND: Recognition of some of the limitations of titanium plates and screws used for the fixation of bones has led to the development of plates manufactured from bioresorbable materials. Whilst resorbable plates appear to offer clinical advantages over metal plates in orthognathic surgery, concerns remain about the stability of fixation and the length of time required for their degradation and the possibility of foreign body reactions. This review compares the use of titanium versus bioresorbable plates in orthognathic surgery and is an update of the Cochrane Review first published in 2007. OBJECTIVES: To compare the effects of bioresorbable fixation systems with titanium systems used during orthognathic surgery. SEARCH METHODS: Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to 20 January 2017); the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 11) in the Cochrane Library (searched 20 January 2017); MEDLINE Ovid (1946 to 20 January 2017); and Embase Ovid (1980 to 20 January 2017). We searched the US National Institutes of Health Ongoing Trials Register ClinicalTrials.gov (clinicaltrials.gov; searched 20 January 2017), and the World Health Organization International Clinical Trials Registry Platform (searched 20 January 2017) for ongoing trials. No restrictions were placed on the language or date of publication when searching the electronic databases. SELECTION CRITERIA: Randomised controlled trials comparing bioresorbable versus titanium fixation systems used for orthognathic surgery in adults. DATA COLLECTION AND ANALYSIS: Two review authors independently screened the results of the electronic searches, extracted data and assessed the risk of bias of the included studies. We resolved disagreement by discussion. Clinical heterogeneity between the included trials precluded pooling of data, and only a descriptive summary is presented. MAIN RESULTS: This review included two trials, involving 103 participants, one comparing titanium with resorbable plates and screws and the other titanium with resorbable screws. Both studies were at high risk of bias and provided very limited data for the primary outcomes of this review. All participants in one trial suffered mild to moderate postoperative discomfort with no statistically significant difference between the two plating groups at different follow-up times. Mean scores of patient satisfaction were 7.43 to 8.63 (range 0 to 10) with no statistically significant difference between the two groups throughout follow-up. Adverse effects reported in one study were two plate exposures in each group occurring between the third and ninth months. Plate exposures occurred mainly in the posterior maxillary region, except for one titanium plate exposure in the mandibular premolar region. Known causes of infection were associated with loosened screws and wound dehiscence with no statistically significant difference in the infection rate between titanium (3/196), and resorbable (3/165) plates. AUTHORS' CONCLUSIONS: We do not have sufficient evidence to determine if titanium plates or resorbable plates are superior for fixation of bones after orthognathic surgery. This review provides insufficient evidence to show any difference in postoperative pain and discomfort, level of patient satisfaction, plate exposure or infection for plate and screw fixation using either titanium or resorbable materials

Overall Dynamic Properties of 3-D periodic elastic composites

A method for the homogenization of 3-D periodic elastic composites is presented. It allows for the evaluation of the averaged overall frequency dependent dynamic material constitutive tensors relating the averaged dynamic field variable tensors of velocity, strain, stress, and linear momentum. The formulation is based on micromechanical modeling of a representative unit cell of a composite proposed by Nemat-Nasser & Hori (1993), Nemat-Nasser et. al. (1982) and Mura (1987) and is the 3-D generalization of the 1-D elastodynamic homogenization scheme presented by Nemat-Nasser & Srivastava (2011). We show that for 3-D periodic composites the overall compliance (stiffness) tensor is hermitian, irrespective of whether the corresponding unit cell is geometrically or materially symmetric.Overall mass density is shown to be a tensor and, like the overall compliance tensor, always hermitian. The average strain and linear momentum tensors are, however, coupled and the coupling tensors are shown to be each others' hermitian transpose. Finally we present a numerical example of a 3-D periodic composite composed of elastic cubes periodically distributed in an elastic matrix. The presented results corroborate the predictions of the theoretical treatment.Comment: 26 pages, 2 figures, submitted to Proceedings of the Royal Society

Pharmaceutical Industry in Uganda: A Review of the Common GMP Non-conformances during Regulatory Inspections

The prevalence of substandard medicines in Africa is high but not well documented. Low and Middle-Income Countries (LMICs) are likely to face considerable challenges with substandard medications. Africa faces inadequate drug regulatory practices, and in general, compliance with Good Manufacturing Practices (GMP) in most of the pharmaceutical industries is lacking. The majority of pharmaceutical manufacturers in developing countries are often overwhelmed by the GMP requirements and therefore are unable to operate in line with internationally acceptable standards. Non-conformances observed during regulatory inspections provide the status of the compliance to GMP requirements. The study aimed to identify the GMP non-conformances during regulatory inspections and gaps in the production of pharmaceuticals locally manufactured in Uganda by review of the available 50 GMP reports of 21 local pharmaceutical companies in Uganda from 2016. The binary logistic generalized estimating equations (GEE) model was applied to estimate the association between odds of a company failing to comply with the GMP requirements and non-conformances under each GMP inspection parameter. Analysis using dummy estimation to linear regression included determination of the relationship that existed between the selected variables (GMP inspection parameters) and the production capacity of the local pharmaceutical industry. Oral liquids, external liquid preparations, powders, creams, and ointments were the main categories of products manufactured locally. The results indicated that 86% of the non-conformances were major, 11% were minor, and 3% critical. The majority of the non-conformances were related to production (30.1%), documentation (24.5%), and quality control (17.6%). Regression results indicated that for every non-conformance under premises, equipment, and utilities, there was a 7-fold likelihood of the manufacturer failing to comply with the GMP standards (aOR=6.81, P=0.001). The results showed that major non-conformances were significantly higher in industries of small scale (B=6.77, P=0.02) and medium scale (B=8.40, P=0.04), as compared to those of large scale. This study highlights the failures in quality assurance systems and stagnated GMP improvements in these industries that need to be addressed by the manufacturers with support from the regulator. The addition of risk assessment to critical production and quality control operations and establishment of appropriate corrective and preventive actions as part of quality management systems are required to ensure that quality pharmaceuticals are manufactured locally

Construction of Prioritized T-Way Test Suite Using Bi-Objective Dragonfly Algorithm

Software testing is important for ensuring the reliability of software systems. In software testing, effective test case generation is essential as an alternative to exhaustive testing. For improving the software testing technology, the t-way testing technique combined with metaheuristic algorithm has been great to analyze a large number of combinations for getting optimal solutions. However, most of the existing t-way strategies consider test case weights while generating test suites. Priority of test cases hasn’t been fully considered in previous works, but in practice, it’s frequently necessary to distinguish between high-priority and low-priority test cases. Therefore, the significance of test case prioritization is quite high. For this reason, this paper has proposed a t-way strategy that implements an adaptive Dragonfly Algorithm (DA) to construct prioritized t-way test suites. Both test case weight and test case priority have equal significance during test suite generation in this strategy. We have designed and implemented a Bi-objective Dragonfly Algorithm (BDA) for prioritized t-way test suite generation, and the two objectives are test case weight and test case priority. The test results demonstrate that BDA performs competitively against existing t-way strategies in terms of test suite size, and in addition, BDA generates prioritized test suites.©2022 Authors. Published by IEEE. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. For more information, see https://creativecommons.org/licenses/by-nc-nd/4.0/fi=vertaisarvioitu|en=peerReviewed

Shear Viscosity in a Perturbative Quark-Gluon-Plasma

Among the key features of hot and dense QCD matter produced in ultra-relativistic heavy-ion collisions at RHIC is its very low shear viscosity, indicative of the properties of a near-ideal fluid, and a large opacity demonstrated by jet energy loss measurements. In this work, we utilize a microscopic transport model based on the Boltzmann equation with quark and gluon degrees of freedom and cross sections calculated from perturbative Quantum Chromodynamics to simulate an ideal Quark-Gluon-Plasma in full thermal and chemical equilibrium. We then use the Kubo formalism to calculate the shear viscosity to entropy density ratio of the medium as a function of temperature and system composition. One of our key results is that the shear viscosity over entropy-density ratio $\eta/s$ becomes invariant to the chemical composition of the system when plotted as a function of energy-density instead of temperature.Comment: 11 pages, 8 figures: version #2 contains some revisions and added references to clarify relationship to previously published wor

Advanced plasmonic interfaces for optimized light trapping in photovoltaics

Plasmonic interfaces are integrated to photovoltaic devices to enhance light trapping and improve efficiency. The optimum thickness of the spacer layer used to passivate the absorber layer and adjust its distance from the metal nanoparticles remains unclear. We integrate plasmonic interfaces consisting of Ag nanoparticles and silicon nitride spacers of different thicknesses to the back of a-Si:H absorber to investigate the optimum thickness of the spacer layer and use the photocurrent in a-Si:H to indicate the enhancement in light-trapping. For integration to the back or front of the device, the localized surface plasmon resonance (LSPR) is shifted and broadened into the red with increased spacer layer thickness and the effect is more pronounced for integration to the back. An appreciable enhancement of photocurrent in a-Si:H is consistent with this broadening of LSPR and has a critical dependence on spacer layer thickness

Comparative Performance Analysis of Flower Pollination Algorithm and Harmony Search based strategies: A Case Study of Applying Interaction Testing in the Real World

The main purpose of software testing is to detect software failures to ensure that that a product functions work as expected. Therefore there is need to test hug possible number of input combinations. T-way testing is a sampling approach to minimize input combinations. Recently, adapting optimization algorithm for T-way testing is very interested. As a consequence, many t-way optimization algorithm based strategies have been designed and implemented. In order to guide software tester to choose the best software testing strategy, there is a need to evaluate and benchmark the performance of each strategy against common case studies. In this paper, we present a comparison between two strategies, Harmony Search (HS) and Flower Pollination Algorithm (FPA) based strategies. Our experiments have performed on a real-world case study. Experiments results demonstrate that the performance is almost the same for both strategies and there is no one strategy can always be the best; however HS-based strategy performs better than FPA-based in many cases