CYTOKINE STATUS IN PATIENTS WITH URTICARIA

Research objective. The present research evaluates some indicators of cytokine status in patients with urticaria for evaluation of the clinical course. Material and methods. 93 patients with urticaria at the age from 14 to 88 years were examined. The severity of the clinical course was assessed according to the Urticaria activity score-7. The determination of total IgE and IL-4, IL-6 and IL-10 was performed by ELISA. The digital material is processed by the method of variational statistics. Results. In patients with urticaria in cytokine status, there is an increase in anti-(IL-4, IL-6) and proinflammatory (IL-10) cytokines against a background of hyperproduction of total IgE. Conclusion: In patients with chronic urticaria there is a predominance of IL-6 production against the background of hyperproduction of total IgE and IL-10, causing a pronounced secondary immunological failure and decompensatory form

Sport employment and the level of the physical activity of the students

Objective: to determine the structure and the level of physical activity of sedentary children, and those, who practice sports. Materials and methods: the study included 514 children, including 237 girls and 277 boys 7-18 years old (mean age - 14±0.25 years (M±m)) from regular school, academic lyceum and vocational lyceum in Tashkent. Participants were interviewed with a questionnaire to identify sports that they were engaged in and sports that they would like to be engaged in. To determine the level of physical activity we analyzed the participation time records (for 8-9 people in each age and gender group). All examined children were divided into 2 groups: 1st group - who regulary practice sports; 2nd group - sedentary children. Results: 43.8% of participants were engaged in sports, and the boys were involved in sport 2.4 times more often than girls. The majority of boys were engaged in different types of martial arts, coordination and team sports; the majority of girls was engaged in coordination and strength and power sports. Conclusions: more than half of children-athletes, in addition to the main type of sports, would like to have another kind of sport activity to train other muscle groups. 78.1% of children not involved in sports would like to visit the sports section. The duration of physical activity met the requirements only in male athletes

EVALUATION OF THE RESULTS OF ANTHROPOMETRIC STUDIES OF ATHLETES IN DIFFERENT ATHLETICS DISCIPLINES

This article discusses the main anthropometric characteristics of athletes involved in various disciplines of athletics in Samarkand. The study involved 100 athletes in the discipline of athletic

MODERN METHODS FOR THE DIAGNOSIS OF ALLERGIC SKIN DISEASES

In recent years, there has been a tendency towards an increase in the incidence of allergic dermatoses, especially their severe cases, which are resistant to treatment. It results from environmental pollution, increased radiation background, the wide use of immunosuppressants, broad-spectrum antibiotics, etc. The disease is diagnosed based on the anamnesis, the results of skin and provocative tests, and the assessment of serum specific IgE. However, the diagnosis of allergic dermatoses presents some difficulties that are caused by polysensitization, when the above diagnostic methods for identifying a causally significant or true allergen are sometimes not sufficient. The introduction of modern methods of diagnosing allergic dermatoses into dermatological practice will allow doctors to expand the methodological tactics of optimal therapy methods, which ultimately will result in the improvement of the quality of life of patients. The present article analyzes modern methods for the diagnosis of allergic skin diseases that contribute to determining the severity of the clinical course and patient management tactics