Vegetation mapping of Žumberak – Samoborsko gorje Nature Park, Croatia, using Landsat 7 and field data

A vegetation map of @umberak – Samoborsko gorje Nature Park with a minimum mapping unit of 2.25 ha (22500m2) was created during 2003. ALandsat ETM+ satellite image (acquired in the year 2000) and the results of field sampling were combined as mapping method. Given the constraints of the minimum mapping unit chosen, 17 classes were identified in the field and designated to corresponding polygons created by the classification of satellite image. Thirteen classes were plant communities or their combinations, while remaining four denoted various types of land cover (coniferous plantations, mixed rural landscapes, settlements and quarries). In the overall area of the Nature Park (344 km2), the most frequent type of cover was Lamio orvalae – Fagetum forest (38.4%of total area), while the most frequent non-forest community was Bromo – Plantaginetum mediae (7.9%). According to this research, as much as 77.3%of Park area is covered with forest, which is a significant increase compared to the old data of 61 % of forests. Analyses of mapped polygons showed that almost a quarter of all polygons has an area equal to, or just little bigger than the minimum mapping unit, while more than three quarters of all polygons have their area smaller or equal to 9 ha (corresponds to 300 x 300 meters square). Such an extreme mosaic landscape structure in conjunction with the constant depopulation of Park area causes further natural forestation of park and hence decreases in biodiversity. The overall accuracy of map was 65%, forest vegetation being mapped with higher accuracy (70%) than non-forest vegetation (61%)

Influence of Father’s Weight and Height on Weight of Male and Female Newborns

The study included 1,596 newborns and their parents living in Šibenik County, Croatia. All newborns are born between 37 and 42 weeks of gestation, with no congenital anomalies and from a single pregnancy. Fathers and mothers of male babies are older than those of girl babies (p < 0.01). Mean values for weight, height, BMI in parents and the woman’s parity are equal (p = 0.05). Pregnancy with male baby lasts longer and the babies are heavier (p < 0.05). Where the fathers weight between 70 and 79 kg and 80 to 89 kg, and where the fathers are 175 to 179 cm or 180 to 184 cm tall with normal BMI the male babies are heavier than the females at birth (p < 0.05). Increased weight, height and BMI in the father increase the birth weight of both male and female babies (p < 0.00001). The authors concludes that parents (father and/or mother) of male babies are older than those of girls, that pregnancy for males babies lasts longer and that male babies are born heavier than girls. With increased weight, and height and BMI in the father, the birth weight of both male and female babies increases

The Effect of High Birth Weight (4000 g or More) on the Weight and Height of Adult Men and Women

Three hundred and twenty eight examined adult men and 346 examined adult women were macrosomic at birth (4000 g or over). The control group consisted of 564 adult men and 749 adult women with birth weights of 2500 to 3999 g. Both male and female macrosomic babies achieve greater weights and heights in adulthood than those in the control group. There are more overweight and obese men in the macrosomic group than in the control group and the same is true of the women (p < 0.001). The mean values of the BMI (body mass index) for the macrosomic adults are greater than those for the control group (p < 0.001). Fetal macrosomia is a good predictor of the weight and height of adult men and women

Les intoxications chez les enfants et l\u27organisation de la prevention et du traitement

U radu se analiziraju podaci o bolesnicima liječenim u bolnici u devetogodišnjem razdoblju, te se utvrđuje da je problem otrovanja u djece stalno prisutan i da ne pokazuje tendenciju sniženja. Upozorava se na mogućnost prikladnijeg organiziranja u sprečavanju i zbrinjavanju otrovanja u djece.Dans ce travail sont analysées des données rassemblées dans un hôpital durant une période de 9 années. On a trouvé que le problème des intoxications chez les enfants est toujours présent et ne tend pas á diminuer. La possibilité d\u27une organisation plus adéquate dans la prévention et le traitement des intoxications chez les enfants est montrée

Vegetation mapping of Žumberak – Samoborsko gorje Nature Park, Croatia, using Landsat 7 and field data

A vegetation map of @umberak – Samoborsko gorje Nature Park with a minimum mapping unit of 2.25 ha (22500m2) was created during 2003. ALandsat ETM+ satellite image (acquired in the year 2000) and the results of field sampling were combined as mapping method. Given the constraints of the minimum mapping unit chosen, 17 classes were identified in the field and designated to corresponding polygons created by the classification of satellite image. Thirteen classes were plant communities or their combinations, while remaining four denoted various types of land cover (coniferous plantations, mixed rural landscapes, settlements and quarries). In the overall area of the Nature Park (344 km2), the most frequent type of cover was Lamio orvalae – Fagetum forest (38.4%of total area), while the most frequent non-forest community was Bromo – Plantaginetum mediae (7.9%). According to this research, as much as 77.3%of Park area is covered with forest, which is a significant increase compared to the old data of 61 % of forests. Analyses of mapped polygons showed that almost a quarter of all polygons has an area equal to, or just little bigger than the minimum mapping unit, while more than three quarters of all polygons have their area smaller or equal to 9 ha (corresponds to 300 x 300 meters square). Such an extreme mosaic landscape structure in conjunction with the constant depopulation of Park area causes further natural forestation of park and hence decreases in biodiversity. The overall accuracy of map was 65%, forest vegetation being mapped with higher accuracy (70%) than non-forest vegetation (61%)

Les intoxications chez les enfants et l\u27organisation de la prevention et du traitement

U radu se analiziraju podaci o bolesnicima liječenim u bolnici u devetogodišnjem razdoblju, te se utvrđuje da je problem otrovanja u djece stalno prisutan i da ne pokazuje tendenciju sniženja. Upozorava se na mogućnost prikladnijeg organiziranja u sprečavanju i zbrinjavanju otrovanja u djece.Dans ce travail sont analysées des données rassemblées dans un hôpital durant une période de 9 années. On a trouvé que le problème des intoxications chez les enfants est toujours présent et ne tend pas á diminuer. La possibilité d\u27une organisation plus adéquate dans la prévention et le traitement des intoxications chez les enfants est montrée

Fine nanophased ZnO : Ru and ZnO : Pt powder synthesis through aerosols

Pt/Ru-doped ZnO nanophase particles were synthesized using ultrasonic spray pyrolysis. Particles were obtained through decomposition of zinc nitrate and newly developed Pt(IV) and Ru(III) complexes. The particle morphology, phase composition and chemical structure were revealed in accordance to various analysis methods (XRD, DSC, SEWEDS, TEM) and discussed in terms of precursor chemistry and process parameters. The shape of DSC curves, indicating two exothermic effects above 600 degrees C in both ZnO:Ru and ZnO:Pt, gave an indication of irreversible structural changes and high reactivity of as-prepared powders. The hexagonal wurtzite-type ZnO phase was revealed in both powdered samples. Small content of an intermediate Zn-5(NO3)(2)(OH)(8)(.)2H(2)O and cubic Zn2PtO4 phase were detected in the Pt-doped ZnO particles. Structural refinements, performed by Koalariet-XFit, suggest the composite internal particle structure composed of primary particles sized less than 100 nm. The estimated values for the unit cell parameters and Zn-O bond lengths imply noble metal ions incorporation into ZnO matrix interstitially, probably in octahedral interstitial environment. It has been shown that different particle growing morphologies (either spheroidally or pyramidally shaped) were influenced by the precursor chemistry, processing parameters and the presence of noble metal ions. Among the many parameters, attaining of the particle shape uniformity and homogeneous distribution of the noble metal cations in as-prepared particles are regarded as the most important factors for dominating microstructure evolution

Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes

Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl) propanoic acid as ligands were prepared from p-cymene ruthenium dichloride dimer and corresponding ester. All compounds have been characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR spectroscopy. Single crystal X-ray structure diffraction analysis of C1 shows the usual piano-stool geometry of complexes, with coordination of ester ligand via nitrogen donor atoms. Ligands exhibit moderate anticancer activity (IC50 gt 50 mu M), while the complexes were significantly more cytotoxic towards various cancer cell lines, including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0 mu M). We stress that cisplatin resistant HCT116 cell line was highly sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M versus IC50 gt 120 mu M for cisplatin). In parallel, primary fibroblasts-MRC-5 were remarkably less affected by these compounds. (C) 2013 Elsevier B. V. All rights reserved

[Pt(HPxSC)Cl-3], a novel platinum(IV) compound with anticancer properties

There has been a continuing effort for the discovery of novel platinum(IV)-based antitumor compounds with better therapeutic performances than cisplatin. In the present work, the anticancer action of recently synthesized Pt(IV)-based complex [Pt(HPxSC)Cl-3] was investigated using rat and human astrocytoma cell lines C6 and U251. [Pt(HPxSC)Cl-3] markedly reduced the number of cultured astrocytoma Cells (IC50, 80 mu M), as determined by crystal violet assay. The Pt(IV) complex induced apoptotic death of tumor cells, as flow cytometry analysis of the propidium iodide-stained cellular DNA revealed approx. 30% of hypodiploid cells in [Pt(HPxSC)Cl-3]-treated astrocytoma cell cultures. On the other hand, [Pt(HPxSC)Cl-3] at 200 mu M did not affect the viability of rat primary astrocytes, unlike the established anticancer drug cisplatin, which displayed high toxicity toward both astrocytoma cells (IC50, 15 mu M) and primary astrocytes (IC50, 20 mu M). Moreover, [Pt(HPxSC)Cl-3] at 100 mu M did not interfere with the ability of rat peritoneal macrophages to produce important antitumor molecules nitric oxide and tumor necrosis factor-a. Finally, we assessed the ability of [Pt(HPxSC)Cl-3] to restrain growth of some bacterial and yeast strains, but it showed rather limited antimicrobial activity. (c) 2005 Elsevier B.V. All rights reserved.nul

Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity

This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved