Architects of time: Labouring on digital futures

Drawing on critical analyses of the internet inspired by Gilles Deleuze and the Marxist autonomia movement, this paper suggests a way of understanding the impact of the internet and digital culture on identity and social forms through a consideration of the relationship between controls exercised through the internet, new subjectivities constituted through its use and new labour practices enabled by it. Following Castells, we can see that the distinction between user, consumer and producer is becoming blurred and free labour is being provided by users to corporations. The relationship between digital technologies and sense of community, through their relationship to the future, is considered for its dangers and potentials. It is proposed that the internet may be a useful tool for highlighting and enabling social connections if certain dangers can be traversed. Notably, current remedies for the lack of trust on the internet are questioned with an alternative, drawing on Zygmunt Bauman and Georg Simmel, proposed which is built on community through a vision of a ‘shared network’

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.

Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the development of itch and the acute-to-chronic itch transition remain unknown. Here, we show that skin-infiltrating neutrophils are key initiators of itch in atopic dermatitis, the most prevalent chronic itch disorder. Neutrophil depletion significantly attenuated itch-evoked scratching in a mouse model of atopic dermatitis. Neutrophils were also required for several key hallmarks of chronic itch, including skin hyperinnervation, enhanced expression of itch signaling molecules, and upregulation of inflammatory cytokines, activity-induced genes, and markers of neuropathic itch. Finally, we demonstrate that neutrophils are required for induction of CXCL10, a ligand of the CXCR3 receptor that promotes itch via activation of sensory neurons, and we find that that CXCR3 antagonism attenuates chronic itch

Choosing more mathematics : happiness through work?

This paper examines how A-level students construct relationships between work and happiness in their accounts of choosing mathematics and further mathematics A-level. I develop a theoretical framework that positions work and happiness as opposed, managed and working on the self and use this to examine students' dual engagement with individual practices of the self and institutional practices of school mathematics. Interviews with students acknowledge four imperatives that they use as discursive resources to position themselves as successful/unsuccessful students: you have to work, you have to not work, you have to be happy, you have to work at being happy. Tensions in these positions lead students to rework their identities or drop further mathematics. I then identify the practices of mathematics teaching that students use to explain un/happiness in work, and show how dependable mathematics and working together are constructed as 'happy objects' for students, who develop strategies for claiming control over these shapers of happiness. © 2010 British Society for Research into Learning Mathematics

Comments on Anomaly Cancellations by Pole Subtractions and Ghost Instabilities with Gravity

We investigate some aspects of anomaly cancellation realized by the subtraction of an anomaly pole, stressing on some of its properties in superspace. In a local formulation these subtractions can be described in terms of a physical scalar, an axion and related ghosts. They appear to be necessary for the unitarization of the theory in the ultraviolet, but they may generate an infrared instability of the corresponding effective action, signalled by ghost condensation. In particular the subtraction of the superanomaly multiplet by a pole in superspace is of dubious significance, due to the different nature of the chiral and conformal anomalies. In turn, this may set more stringent constraints on the coupling of supersymmetric theories to gravity.Comment: 18 pages. Revised version. To appear in "Classical and Quantum Gravity

Enhanced Intraoperative Visualization for Brain Surgery: A Prototypic Simulated Scenario

Abstract: Due to the required high precision and reliability, image guidance is increasingly being adapted in neurosurgery Problem Medical navigation systems help physicians to establish correspondences between locations in an acquired patient dataset and the patient's physical body during navigated surgeries. This is highly advantageous in neurosurgery, where high precision is demanded. In a microscope-assisted surgery, however, this requires the surgeon to switch between the microscope and wall-mounted or computer displays. By incorporating augmented reality, it becomes possible to view patient data directly in the 3D context of the patient himself. This may provide an in-place insight into the patient body, which, for example, would help defining the entry point and the trajectory of a biopsy needle In this paper, we present a prototype for enhancing intraoperative visualization within the operating microscope, by augmenting the video stream with relevant patient data from different diagnostic and intraoperative imaging modalities. The advantage is a better localization of targeted lesions (e.g. tumor) and the protection of hidden risk structures like blood vessels and neural connections. The prototype includes the different components of a navigated procedure: tracking, calibration, registration, and rendering, which are described in the following section. Methods For our prototype, we implement a marker-based optical tracking system and use a tablet PC with a high resolution built-in camera to simulate the surgical microscope. A phantom model of the head simulates the patient. In the context of this paper, we refer to the tablet PC camera as the video camera and to the camera of the tracking system as the tracker camera. At a first step, the system cameras are calibrated to compute their intrinsic geometrical parameters. This is performed by capturing several photos of a special checkerboard pattern, with the tracker camera, from different Proceedings curac2010@MEDICA 12

Challenging assumptions of the enlargement literature : the impact of the EU on human and minority rights in Macedonia

This article argues that from the very start of the transition process in Macedonia, a fusion of concerns about security and democratisation locked local nationalist elites and international organisations intoa political dynamic that prioritised security over democratisation. This dynamic resulted in little progress in the implementation of human and minority rights until 2009, despite heavy EU involvement in Macedonia after the internal warfare of 2001. The effects of this informally institutionalised relationship have been overlooked by scholarship on EU enlargement towards Eastern Europe, which has made generalisations based on assumptions relevant to the democratisation of countries in Eastern Europe, but not the Western Balkans

The employee as 'Dish of the Day’:human resource management and the ethics of consumption

This article examines the ethical implications of the growing integration of consumption into the heart of the employment relationship. Human resource management (HRM) practices increasingly draw upon the values and practices of consumption, constructing employees as the ‘consumers’ of ‘cafeteria-style’ benefits and development opportunities. However, at the same time employees are expected to market themselves as items to be consumed on a corporate menu. In relation to this simultaneous position of consumer/consumed, the employee is expected to actively engage in the commodification of themselves, performing an appropriate organizational identity as a necessary part of being a successful employee. This article argues that the relationship between HRM and the simultaneously consuming/consumed employee affects the conditions of possibility for ethical relations within organizational life. It is argued that the underlying ‘ethos’ for the integration of consumption values into HRM practices encourages a self-reflecting, self-absorbed subject, drawing upon a narrow view of individualised autonomy and choice. Referring to Levinas’ perspective that the primary ethical relation is that of responsibility and openness to the Other, it is concluded that these HRM practices affect the possibility for ethical being

Safety, tolerability, and impact on allergic inflammation of autologous E.coli autovaccine in the treatment of house dust mite asthma - a prospective open clinical trial

Background: Asthma is increasing worldwide and results from a complex immunological interaction between genetic susceptibility and environmental factors. Autovaccination with E. coli induces a strong TH-1 immune response, thus offering an option for the treatment of allergic diseases. Methods: Prospective open trial on safety, tolerability, and impact on allergic inflammation of an autologous E.coli autovaccine in intermittent or mild persistent house dust mite asthma. Determination of exhaled nitric monoxide (eNO) before and after bronchial mite challenge initially and after nine months of autovaccination. Results: Median eNO increase after autovaccination was significantly smaller (from 27.3 to 33.8 ppb; p=0.334) compared to initial values (from 32.6 to 42.2 ppb; p=0.046) (p=0.034). In nine subjects and a total of 306 injections, we observed 101 episodes of local erythema (33.3%; median of maximal diameter 2.5 cm), 95 episodes of local swelling (31.1%; median of maximal diameter 3 cm), and 27 episodes of local pain (8.8%). Four subjects reported itching at the injection site with a total of 30 episodes (9.8%). We observed no serious adverse events. All organ functions (inclusive electrocardiogramm) and laboratory testing of the blood (clinical chemistry, hematology) and the urine (screening test, B-microglobuline) were within normal limits. Vital signs undulated within the physiological variability. Conclusion: The administration of autologous autovacine for the treatment of house dust mite asthma resulted in a reduction of the eNO increase upon bronchial mite challenge. In nine subjects and 306 injections, only a few mild local reactions and no systemic severe adverse events were observed. EudraCT Nr. 2005-005534-12 ClinicalTrials.gov ID NCT0067720