Field study on adaptive thermal comfort in typical air conditioned classrooms

This study investigates adaptive thermal comfort in air conditioned classrooms in Hong Kong. A field survey was conducted in several typical classrooms at the City University of Hong Kong. This survey covered objective measurement of thermal environment parameters and subjective human thermal responses. A total of 982 student volunteers participated in the investigation. The results indicate that students in light clothing (0.42 clo) have adapted to the cooler classroom environments. The neutral temperature is very close to the preferred temperature of approximately 24 °C. Based on the MTSV ranging between −0.5 and + 0.5, the comfort range is between 21.56 °C and 26.75 °C. The lower limit is below that of the ASHRAE standard. Of the predicted mean vote (PMV) and the University of California, Berkeley (UCB) model, the UCB model predictions agree better with the mean thermal sensation vote (MTSV). Also, the respective fit regression models of the MTSV versus each of the following: operative temperature (Top), PMV, and UCB were obtained. This study provides a better understanding of acceptable classroom temperatures

Time Quantified Monte Carlo Algorithm for Interacting Spin Array Micromagnetic Dynamics

In this paper, we reexamine the validity of using time quantified Monte Carlo (TQMC) method [Phys. Rev. Lett. 84, 163 (2000); Phys. Rev. Lett. 96, 067208 (2006)] in simulating the stochastic dynamics of interacting magnetic nanoparticles. The Fokker-Planck coefficients corresponding to both TQMC and Langevin dynamical equation (Landau-Lifshitz-Gilbert, LLG) are derived and compared in the presence of interparticle interactions. The time quantification factor is obtained and justified. Numerical verification is shown by using TQMC and Langevin methods in analyzing spin-wave dispersion in a linear array of magnetic nanoparticles.Comment: Accepted for publication in Phys. Rev.

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. I. Effect of Lipopolysaccharide on Innate Immunity

The dysregulation of endometrial immune response to bacterial lipopolysaccharide (LPS) has been implicated in uterine disease and infertility in the postpartum dairy cow, although the mechanisms are not clear. Here, we investigated whole-transcriptomic gene expression in primary cultures of mixed bovine epithelial and stromal endometrial cells. Cultures were exposed to LPS for 6 h, and cellular response was measured by bovine microarray. Approximately 30% of the 1006 genes altered by LPS were classified as being involved in immune response. Cytokines and chemokines (IL1A, CX3CL1, CXCL2, and CCL5), interferon (IFN)-stimulated genes (RSAD2, MX2, OAS1, ISG15, and BST2), and the acute phase molecule SAA3 were the most up-regulated genes. Ingenuity Pathway Analysis identified up-regulation of many inflammatory cytokines and chemokines, which function to attract immune cells to the endometrium, together with vascular adhesion molecules and matrix metalloproteinases, which can facilitate immune cell migration from the tissue toward the uterine lumen. Increased expression of many IFN-signaling genes, immunoproteasomes, guanylate-binding proteins, and genes involved in the intracellular recognition of pathogens suggests important roles for these molecules in the innate defense against bacterial infections. Our findings confirmed the important role of endometrial cells in uterine innate immunity, whereas the global approach used identified several novel immune response pathways triggered by LPS in the endometrium. Additionally, many genes involved in endometrial response to the conceptus in early pregnancy were also altered by LPS, suggesting one mechanism whereby an ongoing response to infection may interfere with the establishment of pregnancy

Viscous Effects on Elliptic Flow and Shock Waves

Fast thermalization and a strong buildup of elliptic flow of QCD matter as found at RHIC are understood as the consequence of perturbative QCD (pQCD) interactions within the 3+1 dimensional parton cascade BAMPS. The main contributions stem from pQCD bremsstrahlung $2 \leftrightarrow 3$ processes. By comparing to Au+Au data of the flow parameter $v_2$ as a function of participation number the shear viscosity to entropy ratio is dynamically extracted, which lies in the range of 0.08 and 0.2, depending on the chosen coupling constant and freeze out condition. Furthermore, first simulations on the temporal propagation of dissipative shock waves are given. The cascade can either simulate true ideal shocks as well as initially diluted, truely viscous shocks, depending on the employed cross sections or mean free path, respectively.Comment: 7 pages, 8 figures, to appear in the proceedings of the 2008 Erice School on Nuclear Physics, Sicil

Analytical Solution to Transport in Brownian Ratchets via Gambler's Ruin Model

We present an analogy between the classic Gambler's Ruin problem and the thermally-activated dynamics in periodic Brownian ratchets. By considering each periodic unit of the ratchet as a site chain, we calculated the transition probabilities and mean first passage time for transitions between energy minima of adjacent units. We consider the specific case of Brownian ratchets driven by Markov dichotomous noise. The explicit solution for the current is derived for any arbitrary temperature, and is verified numerically by Langevin simulations. The conditions for vanishing current and current reversal in the ratchet are obtained and discussed.Comment: 4 pages, 3 figure

Acute BVDV infection inhibits expression of interferon-stimulated genes during pregnancy recognition in bovine endometrium

Bovine viral diarrhea virus (BVDV) can evade host detection by downregulation of interferon signaling pathways. Infection of cows with noncytopathic (ncp) BVDV can cause early embryonic mortality. Upregulation of type I interferon stimulated genes (ISGs) by blastocyst-secreted interferon tau (IFNT) is a crucial component of the maternal recognition of pregnancy (MRP) in ruminants. This study investigated the potential of acute BVDV infection to disrupt MRP by modulating endometrial ISG expression. Endometrial cells from 10 BVDV-free cows were cultured and treated with 0 or 100 ng/ml IFNT for 24 h in the absence or presence of ncpBVDV infection to yield four treatment groups: CONT, ncpBVDV, IFNT, or ncpBVDV+IFNT. ncpBVDV infection alone only upregulated TRIM56, but reduced mRNA expression of ISG15, MX2, BST2, and the proinflammatory cytokine IL1B. As anticipated, IFNT treatment alone significantly increased expression of all 17 ISGs tested. In contrast to the limited effect of ncpBVDV alone, the virus markedly inhibited IFNT-stimulated expression of 15 ISGs tested (ISG15, HERC5, USP18, DDX58, IFIH1, IFIT1, IFIT3, BST2, MX1, MX2, RSAD2, OAS1Y, SAMD9, GBP4, and PLAC8), together with ISG15 secreted protein. Only TRIM56 and IFI27 expression was unaltered. IL1B expression was reduced by the combined treatment. These results indicate that acute ncpBVDV infection may decrease uterine immunity and lead to MRP failure through inhibition of IFNT-stimulated endometrial ISG production. This in turn could reduce fertility and predispose cows to uterine disease, while evasion of the normal uterine immune response by ncpBVDV may contribute to maintenance and spreading of this economically important disease

Formation and kinetics of transient metastable states in mixtures under coupled phase ordering and chemical demixing

We present theory and simulation of simultaneous chemical demixing and phase ordering in a polymer-liquid crystal mixture in conditions where isotropic- isotropic phase separation is metastable with respect to isotropic-nematic phase transition. It is found that mesophase formation proceeds by a transient metastable phase that surround the ordered phase, and whose lifetime is a function of the ratio of diffusional to orientational mobilities. It is shown that kinetic phase ordering in polymer-mesogen mixtures is analogous to kinetic crystallization in polymer solutions.Comment: 17 pages, 5 figures accepted for publication in EP

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide

Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial lipopolysaccharide (LPS). Primary cultures of mixed epithelial and stromal cells were divided into four treatment groups (control [CONT], BVDV, CONT+LPS, and BVDV+LPS) and infected with ncpBVDV for 4 days followed by treatment with LPS for 6 h. Whole-transcriptomic gene expression was measured followed by Ingenuity Pathway Analysis. Differential expression of 184 genes was found between CONT and BVDV treatments, showing interplay between induction and inhibition of responses. Up-regulation of TLR3, complement, and chemotactic and TRIM factors by ncpBVDV all suggested an ongoing immune response to viral infection. Down-regulation of inflammatory cytokines, chemokines, CXCR4, and serine proteinase inhibitors suggested mechanisms by which ncpBVDV may simultaneously counter the host response. Comparison between BVDV+LPS and CONT+LPS treatments showed 218 differentially expressed genes. Canonical pathway analysis identified the key importance of interferon signaling. Top down-regulated genes were RSAD2, ISG15, BST2, MX2, OAS1, USP18, IFIT3, IFI27, SAMD9, IFIT1, and DDX58, whereas TRIM56, C3, and OLFML1 were most up-regulated. Many of these genes are also regulated by IFNT during maternal recognition of pregnancy. Many innate immune genes that typically respond to LPS were inhibited by ncpBVDV, including those involved in pathogen recognition, inflammation, interferon response, chemokines, tissue remodeling, cell migration, and cell death/survival. Infection with ncpBVDV can thus compromise immune function and pregnancy recognition, thereby potentially predisposing infected cows to postpartum bacterial endometritis and reduced fertility