Risk Identification And Analysis Of Precast Concrete Structure Based On Work Breakdown Structure-Risk Breakdown Structure

Because the prefabricated building started late in China, and subject to management and technical restrictions, the safety problems during the construction of the prefabricated building have not been solved effectively. In view of the problems of complex environments in precast concrete structure and many influencing factors which makes the construction risks are difficult to identify. The work breakdown structure (WBS) - risk breakdown structure (RBS) method is introduced to solve the problem. By means of analyzing the investigation data of the prefabricated building accidents, its risks during construction are identified and coupled. Then the judgment matrix is obtained and the corresponding risk factors can be established. In the meanwhile, the fault tree analysis method has been being used to analyze the sensitivity of three kinds of accidents, such as falling, striking by object and electrocution. The sensitive coefficients of risk factors are calculated and sorted. The result shows that the main risk factors of falling accident are verticality deviation of component installation, deviation of component position and unsecured mechanics. The main risk factors of striking by object/equipment are insufficient strength of components supporting, overturning components and unreasonable of suspension point. The main risk factors of electrocution are improper welding operation and short circuit. Finally, corresponding control measures are put forward according to the risk accidents. The research results provided a good theoretical basis for the risk identification of prefabricated building construction

Vibration analysis of a beam on a moving vehicle under the road excitation with different contact models

Dynamic analysis of a beam on a moving vehicle is presented in this paper. The vehicle is simulated by a four degrees-of-freedom mass-spring system and the beam on top is supported by spring-damping systems. Two contact models named the ‘point contact’ and the ‘patch contact’ respectively, are adopted to simulate the interaction between road surface and vehicular tyres. The equation of motion of the beam-vehicle system is formulated and the dynamic response on the beam under the excitation of the irregular road surface is derived. Numerical simulations are conducted to demonstrate the influence of different factors, such as the length of the contact, the velocity of vehicle, the road condition and the bracing stiffness, etc. on the vibration level of the beam structure, which aims to provide references on the vibration problem in transporting a beam-shaped package

Influence of slope aspect on the microbial properties of rhizospheric and non-rhizospheric soils on the Loess Plateau, China

Slope aspect is an important topographic factor in the micro-ecosystem environment, but its effect on the microbial properties of grassland rhizospheric soil (RS) and non-rhizospheric soil (NRS) remain unclear. A field experiment was conducted at the Ansai Research Station on the Loess Plateau in China to test the influence of slope aspects (south-facing, north-facing, and northwest-facing slopes, all with Artemisia sacrorum as the dominant species) on RS and NRS microbial biomass carbon (MBC) contents, phospholipid fatty acid (PLFA) contents, and the rhizospheric effect (RE) of various microbial indices. Soil samples were collected from the three slope aspects, including rhizospheric and non-rhizospheric region, and analyzed to determine the various related microbial indices. The results showed that MBC content differed significantly among the slope aspects in RS but not in NRS, and the RE for MBC content in the south-facing slope was larger than that in the north-facing slope. RS total, bacterial, and Gram-positive bacterial PLFA contents in the south-facing slope were significantly lower than those in the north- and northwest-facing slopes, and RS Gram-negative bacterial (G−) and actinomycete PLFA contents in the south-facing slope were significantly lower than those in the north-facing slope. In contrast, NRS total, bacterial, and G− PLFA contents in the north-facing slope were significantly higher than those in the south- and northwest-facing slopes, and NRS fungal and actinomycete PLFA contents in the north- and south-facing slopes were significantly higher than those in the northwest-facing slope. RE for all PLFA contents except fungal in the northwest-facing slope were higher than those in the south-facing slope. Slope aspect significantly but differentially affected the microbial properties in RS and NRS, and the variable influence was due to an evident RE for most microbial properties.</p

Homogeneous metamaterial description of localised spoof plasmonics in spiral geometries

It has been recently shown that ultrathin spiral metamaterials can support localized spoof plasmon modes whose resonant wavelength is much larger than the size of the structure. Here, an analytical model is developed to describe the electromagnetic properties of the two-dimensional version of these devices: a perfect conducting wire corrugated by spiral grooves. The emergence of localized spoof plasmons in this geometry is quantitatively investigated. Calculations show that these modes can be engineered through the spiral angle and the number of grooves. The theory also allows us to elucidate the contribution of magnetic and electric localized spoof plasmons to the optical response of these metamaterial devices. Finally, experimental evidence of the existence of these modes in extremely thin textured copper disks is also presented

Water Oxidation with Cobalt‐Loaded Linear Conjugated Polymer Photocatalysts

We report here the first examples of linear conjugated organic polymer photocatalysts that produce oxygen from water after loading with cobalt and in the presence of an electron scavenger. The oxygen evolution rates, which are higher than for related organic materials, can be rationalized by a combination of the thermodynamic driving force for water oxidation, the light absorption of the polymer, and the aqueous dispersibility of the relatively hydrophilic polymer particles. We also used transient absorption spectroscopy to study the best performing system and we found that fast oxidative quenching of the exciton occurs (picoseconds) in the presence of an electron scavenger, minimizing recombination

Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma.

Long non-coding RNAs (lncRNAs) have a critical role in cancer initiation and progression, and thus may mediate oncogenic or tumor suppressing effects, as well as be a new class of cancer therapeutic targets. We performed high-throughput sequencing of RNA (RNA-seq) to investigate the expression level of lncRNAs and protein-coding genes in 30 esophageal samples, comprised of 15 esophageal squamous cell carcinoma (ESCC) samples and their 15 paired non-tumor tissues. We further developed an integrative bioinformatics method, denoted URW-LPE, to identify key functional lncRNAs that regulate expression of downstream protein-coding genes in ESCC. A number of known onco-lncRNA and many putative novel ones were effectively identified by URW-LPE. Importantly, we identified lncRNA625 as a novel regulator of ESCC cell proliferation, invasion and migration. ESCC patients with high lncRNA625 expression had significantly shorter survival time than those with low expression. LncRNA625 also showed specific prognostic value for patients with metastatic ESCC. Finally, we identified E1A-binding protein p300 (EP300) as a downstream executor of lncRNA625-induced transcriptional responses. These findings establish a catalog of novel cancer-associated functional lncRNAs, which will promote our understanding of lncRNA-mediated regulation in this malignancy

Strategy evaluation and optimization with an artificial society toward a Pareto optimum

Strategy evaluation and optimization in response to troubling urban issues has become a challenging issue due to increasing social uncertainty, unreliable predictions, and poor decision-making. To address this problem, we propose a universal computational experiment framework with a fine-grained artificial society that is integrated with data-based models. The purpose of the framework is to evaluate the consequences of various combinations of strategies geared towards reaching a Pareto optimum with regards to efficacy versus costs. As an example, by modeling coronavirus 2019 mitigation, we show that Pareto frontier nations could achieve better economic growth and more effective epidemic control through the analysis of real-world data. Our work suggests that a nation’s intervention strategy could be optimized based on the measures adopted by Pareto frontier nations through large-scale computational experiments. Our solution has been validated for epidemic control, and it can be generalized to other urban issues as well

Polo-like kinase 1 siRNA-607 induces mitotic arrest and apoptosis in human nasopharyngeal carcinoma cells

Polo-like kinase (Plk) 1 is overexpressed in many human malignancies including nasopharyngeal carcinoma, indicating its potential as a therapeutic target. Recently, using a simple cellular morphologybased strategy, we have identified several novel effective siRNAs against Plk1 including Plk1 siRNA- 607. In this study, we further investigated the effects of Plk1 siRNA-607 in human nasopharyngeal carcinoma cell line, HNE-1. Real time RT-PCR and Western blot indicated that Plk1 siRNA-607 transfection resulted in a significant inhibition in Plk1 expression in the HNE-1 cells. Furthermore, cell cycle, cell growth and apoptosis analysis clearly indicated that Plk1 siRNA-607 caused a dramatic mitotic cell cycle arrest followed by massive apoptotic cell death, and eventually resulted in a significant decrease in growth and viability of the nasopharyngeal carcinoma cells. Given that Plk1 has been widely accepted as a novel efficient target for cancer therapy, these results suggested that Plk1 siRNA-607 could be further developed for the treatment of human nasopharyngeal carcinoma.Key words: Nasopharyngeal carcinoma, Plk1, RNA silencing, cell cycle, apoptosis